Details of Drug

Drug General Information (ID: D0900)
Drug Name	Leflunomide
Drug Type	Small molecule
Drug Synonymous	Arava; Leflunomid; Leflunomida; Leflunomidum; Lefunamide; Aventis Behring Brand of Leflunomide; Aventis Brand of Leflunomide; Aventis Pharma Brand of Leflunomide; Hoechst Brand of Leflunomide; HWA 486; L 5025; SU 101; SU101; Arava (TN); Arava, Leflunomide; HWA-486; Leflunomida [INN-Spanish]; Leflunomide [USAN:INN]; Leflunomidum [INN-Latin]; Lefunomide [Inn-Spanish]; RS-34821; SU 101 (pharmaceutical); SU-101; AP-501/42475599; Leflunomide (JAN/USAN/INN); N-(4-trifluoromethyphenyl)-5-methylisoxazole-4-carboxamide; N-(4'-Trifluoromethylphenyl)-5-methylisoxazole-4-carboxamide; Alpha,alpha,alpha-Trifluoro-5-methyl-4-isoxazolecarboxy-p-toluidide; 4-Isoxazolecarboxamide, 5-methyl-N-(4-(trifluoromethyl)phenyl; 4-isoxazolecarboxamide,5-methyl-N-(4-(trifluoromethyl)phenyl); 5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazolecarboxamide; 5-Methylisoxazole-4-(4-trifluoromethyl)carboxanilide; 5-Methylisoxazole-4-(4-trifluoromethylcarboxanilide); 5-Methylisoxazole-4-carboxylic acid (4-trifluoromethyl)anilide; 5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide; 5-methyl-N-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxamide; 5-methyl-N-[4-(trifluoromethyl)phenyl]isoxazole-4-carboxamide Click to Show/Hide
Disease Class	FA20: Rheumatoid arthritis; 8A40: Multiple sclerosis
Therapeutic Class	Antiinflammatory Agents
Structure
Structure	3D Structure		2D Structure
Formula	C12H9F3N2O2
InChI	1S/C12H9F3N2O2/c1-7-10(6-16-19-7)11(18)17-9-4-2-8(3-5-9)12(13,14)15/h2-6H,1H3,(H,17,18)
InChIKey	VHOGYURTWQBHIL-UHFFFAOYSA-N
Canonical SMILES	CC1=C(C=NO1)C(=O)NC2=CC=C(C=C2)C(F)(F)F
External Link
	Pubchem ID	3899
	CAS Number	75706-12-6
	CHEBI ID	6402
	TTD ID	D08ROP
	INTEDE ID	DR0921
	VARIDT ID	DR00130

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM004 Adsorption BM017 CYP450 enzyme inhibition BM043 Additive immunosuppressive effects BM044 Additive myelosuppressive effects BM055 Increased risk of hepatotoxicity BM074 Increased risk of peripheral neuropathy BM100 Antagonize the effect of vaccine/toxoid BM105 Antagonize the effect of probiotics BM106 Diminish the response to diagnostic skin test antigens BM110 Antagonize the effects of immunosuppressants
Relation Graph

Full list of drugs interacting with Leflunomide
Affected gastrointestinal absorption
	Adsorption					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0021		Activated charcoal	C	5462310	Moderate		Inter Info	[3]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 17
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[3], [4]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[3], [4]
D0481		Dicoumarol	C19H12O6	54676038	Moderate		Inter Info	[26], [3], [27]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[3], [4]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[3], [4]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[3], [4]
D0087		Anisindione	C16H12O3	2197	Moderate		Inter Info	[26], [30], [3], [27]
D0905		Lesinurad	C17H14BrN3O2S	53465279	Moderate		Inter Info	[40]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[41]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[3], [4]
D0954		Losartan	C22H23ClN6O	3961	Moderate		Inter Info	[3], [4]
D1087		Montelukast	C35H36ClNO3S	5281040	Moderate		Inter Info	[48], [49]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[50], [51]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[3], [4]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[52], [53], [54]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[55], [56]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[26], [30], [3], [27]
Pharmacodynamic additive effects
	Additive immunosuppressive effects					Drug Num: 161
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Major		Inter Info	[5], [3]
D0032		Alefacept	NA	NA	Major		Inter Info	[3], [4]
D0033		Alemtuzumab	NA	NA	Major		Inter Info	[3], [4]
D0048		Altretamine	C9H18N6	2123	Major		Inter Info	[3], [4]
D0085		Anakinra	C20H23N5O7S2	146171046	Major		Inter Info	[5], [3]
D0094		Antithymocyte immunoglobulin (rabbit)	NA	NA	Major		Inter Info	[3], [4]
D0126		Auranofin	C20H34AuO9PS	24199313	Major		Inter Info	[5], [3]
D0134		Azacitidine	C8H12N4O5	9444	Major		Inter Info	[3], [4]
D0136		Azathioprine	C9H7N7O2S	2265	Major		Inter Info	[5], [3]
D0147		Basiliximab	NA	NA	Major		Inter Info	[3], [4]
D0172		Betamethasone	C22H29FO5	9782	Major		Inter Info	[3], [4]
D0190		Bleomycin	C55H84N17O21S3+	5360373	Major		Inter Info	[3], [4]
D0260		Carboplatin	C6H12N2O4Pt	426756	Major		Inter Info	[3], [4]
D0312		Chlorambucil	C14H19Cl2NO2	2708	Major		Inter Info	[3], [4]
D0344		Cisplatin	Cl2H6N2Pt	5702198	Major		Inter Info	[3], [4]
D0348		Cladribine	C10H12ClN5O3	20279	Major		Inter Info	[5], [6]
D0400		Cyclophosphamide	C7H15Cl2N2O2P	2907	Major		Inter Info	[3], [4]
D0402		Cyclosporine	C62H111N11O12	5284373	Major		Inter Info	[5], [3]
D0410		Dactinomycin	C62H86N12O16	457193	Major		Inter Info	[3], [4]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Major		Inter Info	[3], [4]
D0442		Denileukin diftitox	NA	NA	Major		Inter Info	[3], [4]
D0528		Doxorubicin	C27H29NO11	31703	Major		Inter Info	[3], [4]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Major		Inter Info	[3], [4]
D0553		Efalizumab	NA	NA	Major		Inter Info	[3], [4]
D0584		Epirubicin	C27H29NO11	41867	Major		Inter Info	[3], [4]
D0614		Etanercept	NA	NA	Major		Inter Info	[5], [3]
D0627		Etoposide	C29H32O13	36462	Major		Inter Info	[3], [4]
D0666		Floxuridine	C9H11FN2O5	5790	Major		Inter Info	[3], [4]
D0671		Fludrocortisone	C21H29FO5	31378	Major		Inter Info	[3], [4]
D0675		Fluorouracil	C4H3FN2O2	3385	Major		Inter Info	[3], [4]
D0773		Hydrocortisone	C21H30O5	5754	Major		Inter Info	[3], [4]
D0780		Hydroxyurea	CH4N2O2	3657	Major		Inter Info	[3], [4]
D0784		Ibritumomab tiuxetan	NA	NA	Major		Inter Info	[3], [4]
D0802		Infliximab	NA	NA	Major		Inter Info	[5], [3]
D0845		Irinotecan	C33H38N4O6	60838	Major		Inter Info	[3], [4]
D0004		Abatacept	NA	NA	Major		Inter Info	[5], [3]
D0008		Acalabrutinib	C26H23N7O2	71226662	Major		Inter Info	[3], [4]
D0027		Aflibercept	NA	NA	Major		Inter Info	[3], [4]
D0091		Antilymphocyte immunoglobulin (horse)	NA	NA	Major		Inter Info	[3], [4]
D0118		Atezolizumab	NA	NA	Major		Inter Info	[3], [4]
D0127		Aurothioglucose	C6H11AuO5S	454937	Major		Inter Info	[5], [3]
D0129		Avapritinib	C26H27FN10	118023034	Major		Inter Info	[3], [4]
D0132		Axicabtagene ciloleucel	NA	NA	Major		Inter Info	[3], [4]
D0146		Baricitinib	C16H17N7O2S	44205240	Major		Inter Info	[3], [4]
D0150		Belantamab mafodotin	NA	NA	Major		Inter Info	[3], [4]
D0151		Belatacept	NA	NA	Major		Inter Info	[3], [4]
D0152		Belimumab	NA	NA	Major		Inter Info	[3], [4]
D0157		Bendamustine	C16H21Cl2N3O2	65628	Major		Inter Info	[3], [4]
D0203		Brexucabtagene autoleucel	NA	NA	Major		Inter Info	[3], [4]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Major		Inter Info	[3], [4]
D0209		Brodalumab	NA	NA	Major		Inter Info	[3], [4]
D0215		Budesonide	C25H34O6	5281004	Major		Inter Info	[3], [4]
D0227		Cabazitaxel	C45H57NO14	9854073	Major		Inter Info	[3], [4]
D0246		Canakinumab	NA	NA	Major		Inter Info	[3], [4]
D0249		Capecitabine	C15H22FN3O6	60953	Major		Inter Info	[3], [4]
D0304		Certolizumab pegol	NA	NA	Major		Inter Info	[5], [3]
D0389		Copanlisib	C23H28N8O4	135565596	Major		Inter Info	[3], [4]
D0392		Corticotropin	C207H308N56O58S	16132265	Major		Inter Info	[3], [4]
D0422		Daratumumab	NA	NA	Major		Inter Info	[3], [4]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Major		Inter Info	[3], [4]
D0431		Decitabine	C8H12N4O4	451668	Major		Inter Info	[3], [4]
D0453		Dexamethasone	C22H29FO5	5743	Major		Inter Info	[3], [4]
D0501		Dinutuximab	NA	NA	Major		Inter Info	[3], [4]
D0511		Docetaxel	C43H53NO14	148124	Major		Inter Info	[3], [4]
D0540		Dupilumab	NA	NA	Major		Inter Info	[3], [4]
D0541		Durvalumab	NA	NA	Major		Inter Info	[3], [4]
D0571		Enfortumab vedotin	NA	NA	Major		Inter Info	[3], [4]
D0594		Eribulin	C40H59NO11	11354606	Major		Inter Info	[3], [4]
D0736		Golimumab	NA	NA	Major		Inter Info	[5], [3]
D0747		Guselkumab	NA	NA	Major		Inter Info	[3], [4]
D0785		Ibrutinib	C25H24N6O2	24821094	Major		Inter Info	[3], [4]
D0788		Idarubicin	C26H27NO9	42890	Major		Inter Info	[3], [4]
D0790		Ifosfamide	C7H15Cl2N2O2P	3690	Major		Inter Info	[3], [4]
D0801		Inebilizumab	NA	NA	Major		Inter Info	[3], [4]
D0829		Iobenguane (I-131)	C8H10IN3	60860	Major		Inter Info	[3], [4]
D0851		Isatuximab	NA	NA	Major		Inter Info	[3], [4]
D0873		Ixabepilone	C27H42N2O5S	6445540	Major		Inter Info	[3], [4]
D0875		Ixekizumab	NA	NA	Major		Inter Info	[3], [4]
D0939		Lisocabtagene maraleucel	NA	NA	Major		Inter Info	[3], [4]
D1062		Midostaurin	C35H30N4O4	9829523	Major		Inter Info	[3], [4]
D1079		Mitoxantrone	C22H28N4O6	4212	Major		Inter Info	[3], [4]
D1083		Mogamulizumab	NA	NA	Major		Inter Info	[3], [4]
D1113		Naxitamab	NA	NA	Major		Inter Info	[3], [4]
D1118		Nelarabine	C11H15N5O5	3011155	Major		Inter Info	[3], [4]
D1140		Niraparib	C19H20N4O	24958200	Major		Inter Info	[3], [4]
D1161		Obinutuzumab	NA	NA	Major		Inter Info	[3], [4]
D1162		Ocrelizumab	NA	NA	Major		Inter Info	[3], [4]
D1164		Ofatumumab	NA	NA	Major		Inter Info	[3], [4]
D1167		Olaparib	C24H23FN4O3	23725625	Major		Inter Info	[3], [4]
D1168		Olaratumab	NA	NA	Major		Inter Info	[3], [4]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Major		Inter Info	[3], [4]
D1190		Osimertinib	C28H33N7O2	71496458	Major		Inter Info	[3], [4]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[5], [16]
D1212		Paclitaxel	C47H51NO14	36314	Major		Inter Info	[3], [4]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Major		Inter Info	[3], [4]
D1214		Palbociclib	C24H29N7O2	5330286	Major		Inter Info	[3], [4]
D1305		Plicamycin	C52H76O24	163659	Major		Inter Info	[3], [4]
D1312		Pomalidomide	C13H11N3O4	134780	Major		Inter Info	[3], [4]
D1345		Procarbazine	C12H19N3O	4915	Major		Inter Info	[3], [4]
D1403		Rilonacept	NA	NA	Major		Inter Info	[3], [4]
D1410		Risankizumab	NA	NA	Major		Inter Info	[3], [4]
D1424		Romidepsin	C24H36N4O6S2	5352062	Major		Inter Info	[3], [4]
D1432		Rucaparib	C19H18FN3O	9931954	Major		Inter Info	[3], [4]
D1434		Ruxolitinib	C17H18N6	25126798	Major		Inter Info	[3], [4]
D1435		Sacituzumab govitecan	C76H104N12O24S	91668186	Major		Inter Info	[3], [4]
D1447		Sarilumab	NA	NA	Major		Inter Info	[5], [3]
D1448		Satralizumab	NA	NA	Major		Inter Info	[5], [3]
D1454		Secukinumab	NA	NA	Major		Inter Info	[3], [4]
D1458		Selinexor	C17H11F6N7O	71481097	Major		Inter Info	[3], [4]
D1467		Siltuximab	NA	NA	Major		Inter Info	[3], [4]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[9], [18]
D1479		Sodium aurothiomalate	C4H3AuNa2O4S	22318	Major		Inter Info	[5], [3]
D1529		Tafasitamab	NA	NA	Major		Inter Info	[3], [4]
D1532		Talazoparib	C19H14F2N6O	135565082	Major		Inter Info	[3], [4]
D1549		Temsirolimus	C56H87NO16	6918289	Major		Inter Info	[3], [4]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[9], [5], [4]
D1563		Tetracosactide	C136H210N40O31S	16133802	Major		Inter Info	[3], [4]
D1575		Thiotepa	C6H12N3PS	5453	Major		Inter Info	[3], [4]
D1583		Tildrakizumab	NA	NA	Major		Inter Info	[3], [4]
D1594		Tisagenlecleucel	NA	NA	Major		Inter Info	[3], [4]
D1599		Tocilizumab	NA	NA	Major		Inter Info	[5], [3]
D1600		Tofacitinib	C16H20N6O	9926791	Major		Inter Info	[3], [4]
D1622		Trastuzumab deruxtecan	NA	NA	Major		Inter Info	[3], [4]
D1671		Ustekinumab	NA	NA	Major		Inter Info	[3], [4]
D1685		Vedolizumab	NA	NA	Major		Inter Info	[3], [4]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Major		Inter Info	[3], [4]
D1718		Zanubrutinib	C27H29N5O3	135565884	Major		Inter Info	[3], [4]
D0910		Levamisole	C11H12N2S	26879	Major		Inter Info	[3], [4]
D0933		Linezolid	C16H20FN3O4	441401	Major		Inter Info	[3], [4]
D0996		Melphalan	C13H18Cl2N2O2	460612	Major		Inter Info	[3], [4]
D1041		Methylprednisolone	C22H30O5	6741	Major		Inter Info	[3], [4]
D1077		Mitomycin	C15H18N4O5	5746	Major		Inter Info	[3], [4]
D1093		Muromonab	NA	NA	Major		Inter Info	[3], [4]
D1094		Mycophenolate mofetil	C23H31NO7	5281078	Major		Inter Info	[3], [4]
D1095		Mycophenolic acid	C17H20O6	446541	Major		Inter Info	[3], [4]
D1111		Natalizumab	NA	NA	Major		Inter Info	[22]
D1241		Pemetrexed	C20H21N5O6	135410875	Major		Inter Info	[3], [4]
D1245		Penicillamine	C5H11NO2S	5852	Major		Inter Info	[5], [3]
D1250		Pentostatin	C11H16N4O4	439693	Major		Inter Info	[3], [4]
D1332		Prednisolone	C21H28O5	5755	Major		Inter Info	[3], [4]
D1334		Prednisone	C21H26O5	5865	Major		Inter Info	[3], [4]
D1416		Rituximab	NA	NA	Major		Inter Info	[5], [3]
D1476		Sirolimus	C51H79NO13	5284616	Major		Inter Info	[3], [4]
D1508		Streptozocin	C8H15N3O7	29327	Major		Inter Info	[3], [4]
D1517		Sulfasalazine	C18H14N4O5S	5339	Major		Inter Info	[5], [3]
D1526		Tacrolimus	C44H69NO12	445643	Major		Inter Info	[3], [4]
D1551		Teniposide	C32H32O13S	452548	Major		Inter Info	[3], [4]
D1569		Thalidomide	C13H10N2O4	5426	Major		Inter Info	[3], [4]
D1610		Topotecan	C23H23N3O5	60700	Major		Inter Info	[3], [4]
D1613		Tositumomab	NA	NA	Major		Inter Info	[3], [4]
D1614		Tositumomab (I-131)	NA	NA	Major		Inter Info	[3], [4]
D1621		Trastuzumab	NA	NA	Major		Inter Info	[3], [4]
D1628		Triamcinolone	C21H27FO6	31307	Major		Inter Info	[3], [4]
D1630		Triamcinolone (ophthalmic)	C21H27FO6	31307	Major		Inter Info	[3], [4]
D1639		Trifluridine	C10H11F3N2O5	6256	Major		Inter Info	[3], [4]
D1667		Uracil mustard	C8H11Cl2N3O2	6194	Major		Inter Info	[3], [4]
D1697		Vinblastine	C46H58N4O9	13342	Major		Inter Info	[3], [4]
D1700		Vinorelbine	C45H54N4O8	5311497	Major		Inter Info	[3], [4]
D0443		Denosumab	NA	NA	Moderate		Inter Info	[39]
D1375		Radium Ra 223 dichloride	NA	NA	Moderate		Inter Info	[42]
D1422		Roflumilast	C17H14Cl2F2N2O3	449193	Moderate		Inter Info	[5], [46]
	Additive myelosuppressive effects					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[5], [7], [8]
D0433		Deferiprone	C7H9NO2	2972	Major		Inter Info	[9], [10], [11]
D0710		Ganciclovir	C9H13N5O4	135398740	Moderate		Inter Info	[9], [5], [28], [29]
D1676		Valganciclovir	C14H22N6O5	135413535	Moderate		Inter Info	[9], [5], [28], [29]
	Increased risk of hepatotoxicity					Drug Num: 240
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0001		Abacavir	C14H18N6O	441300	Major		Inter Info	[1], [2], [3]
D0009		Acarbose	C25H43NO18	41774	Major		Inter Info	[1], [2], [3]
D0011		Acetaminophen	C8H9NO2	1983	Major		Inter Info	[1], [2], [3]
D0017		Acetylsalicylic acid	C9H8O4	2244	Major		Inter Info	[2], [3], [4]
D0018		Acitretin	C21H26O3	5284513	Major		Inter Info	[1], [2], [3]
D0030		Aldesleukin	NA	NA	Major		Inter Info	[3]
D0065		Aminosalicylic acid	C7H7NO3	4649	Major		Inter Info	[1], [2], [3]
D0114		Asparaginase Escherichia coli	NA	NA	Major		Inter Info	[3]
D0119		Atomoxetine	C17H21NO	54841	Major		Inter Info	[1], [2], [3]
D0120		Atorvastatin	C33H35FN2O5	60823	Major		Inter Info	[1], [2], [3]
D0139		Azithromycin	C38H72N2O12	447043	Major		Inter Info	[1], [2], [3]
D0156		Benazepril	C24H28N2O5	5362124	Major		Inter Info	[1], [2], [3]
D0178		Bexarotene	C24H28O2	82146	Major		Inter Info	[3]
D0193		Bortezomib	C19H25BN4O4	387447	Major		Inter Info	[3]
D0194		Bosentan	C27H29N5O6S	104865	Major		Inter Info	[1], [2], [3]
D0210		Bromfenac	C15H12BrNO3	60726	Major		Inter Info	[2], [3], [4]
D0255		Carbamazepine	C15H12N2O	2554	Major		Inter Info	[1], [2], [3]
D0264		Carmustine	C5H9Cl2N3O2	2578	Major		Inter Info	[3]
D0268		Caspofungin	C52H88N10O15	2826718	Major		Inter Info	[1], [2], [3]
D0298		Celecoxib	C17H14F3N3O2S	2662	Major		Inter Info	[2], [3], [4]
D0303		Cerivastatin	C26H34FNO5	446156	Major		Inter Info	[1], [2], [3]
D0327		Chlorzoxazone	C7H4ClNO2	2733	Major		Inter Info	[1], [2], [3]
D0350		Clavulanic acid	C8H9NO5	5280980	Major		Inter Info	[1], [2], [3]
D0357		Clofarabine	C10H11ClFN5O3	119182	Major		Inter Info	[3]
D0367		Clotrimazole	C22H17ClN2	2812	Major		Inter Info	[1], [2], [3]
D0404		Cytarabine	C9H13N3O5	6253	Major		Inter Info	[3]
D0407		Dacarbazine	C6H10N6O	135398738	Major		Inter Info	[3]
D0476		Diclofenac	C14H11Cl2NO2	3033	Major		Inter Info	[2], [3], [4]
D0478		Diclofenac (topical)	C14H11Cl2NO2	3033	Major		Inter Info	[2], [3], [4]
D0483		Didanosine	C10H12N4O3	135398739	Major		Inter Info	[1], [2], [3]
D0489		Diflunisal	C13H8F2O3	3059	Major		Inter Info	[2], [3], [4]
D0509		Disulfiram	C10H20N2S4	3117	Major		Inter Info	[1], [2], [3]
D0539		Duloxetine	C18H19NOS	60835	Major		Inter Info	[1], [2], [3]
D0554		Efavirenz	C14H9ClF3NO2	64139	Major		Inter Info	[1], [2], [3]
D0566		Emtricitabine	C8H10FN3O3S	60877	Major		Inter Info	[1], [2], [3]
D0567		Enalapril	C20H28N2O5	5388962	Major		Inter Info	[1], [2], [3]
D0595		Erlotinib	C22H23N3O4	176870	Major		Inter Info	[1], [2], [3]
D0616		Ethambutol	C10H24N2O2	14052	Major		Inter Info	[1], [2], [3]
D0617		Ethanol	C2H6O	702	Major		Inter Info	[1], [2], [3]
D1731		Ethionamide	C8H10N2S	2761171	Major		Inter Info	[1], [2], [3]
D0621		Ethotoin	C11H12N2O2	3292	Major		Inter Info	[1], [2], [3]
D0624		Etodolac	C17H21NO3	3308	Major		Inter Info	[2], [3], [4]
D0639		Felbamate	C11H14N2O4	3331	Major		Inter Info	[1], [2], [3]
D0642		Fenofibrate	C20H21ClO4	3339	Major		Inter Info	[1], [2], [3]
D0645		Fenoprofen	C15H14O3	3342	Major		Inter Info	[2], [3], [4]
D0667		Fluconazole	C13H12F2N6O	3365	Major		Inter Info	[1], [2], [3]
D0680		Flurbiprofen	C15H13FO2	3394	Major		Inter Info	[2], [3], [4]
D0682		Flutamide	C11H11F3N2O3	3397	Major		Inter Info	[1], [2], [3]
D0686		Fluvastatin	C24H26FNO4	446155	Major		Inter Info	[1], [2], [3]
D0695		Fosinopril	C30H46NO7P	55891	Major		Inter Info	[1], [2], [3]
D0713		Gefitinib	C22H24ClFN4O3	123631	Major		Inter Info	[1], [2], [3]
D0714		Gemcitabine	C9H11F2N3O4	60750	Major		Inter Info	[3]
D0717		Gemtuzumab ozogamicin	NA	NA	Major		Inter Info	[3]
D0786		Ibuprofen	C13H18O2	3672	Major		Inter Info	[2], [3], [4]
D0793		Imatinib	C29H31N7O	5291	Major		Inter Info	[3]
D0800		Indomethacin	C19H16ClNO4	3715	Major		Inter Info	[2], [3], [4]
D0821		Interferon alfa-2a, Recombinant	NA	NA	Major		Inter Info	[3]
D0824		Interferon alfa-n1	NA	NA	Major		Inter Info	[3]
D0823		Interferon alfacon-1	NA	NA	Major		Inter Info	[3]
D0826		Interferon beta-1a	NA	NA	Major		Inter Info	[1], [2], [3]
D0827		Interferon beta-1b	NA	NA	Major		Inter Info	[1], [2], [3]
D0828		Interferon gamma-1b	NA	NA	Major		Inter Info	[3]
D0858		Isoniazid	C6H7N3O	3767	Major		Inter Info	[1], [2], [3]
D0863		Isotretinoin	C20H28O2	5282379	Major		Inter Info	[1], [2], [3]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[1], [2], [3]
D0881		Ketoprofen	C16H14O3	3825	Major		Inter Info	[2], [3], [4]
D0884		Labetalol	C19H24N2O3	3869	Major		Inter Info	[1], [2], [3]
D0889		Lamivudine	C8H11N3O3S	60825	Major		Inter Info	[1], [2], [3]
D0006		Abemaciclib	C27H32F2N8	46220502	Major		Inter Info	[3]
D0007		Abiraterone	C24H31NO	132971	Major		Inter Info	[1], [2], [3]
D0026		Afatinib	C24H25ClFN5O3	10184653	Major		Inter Info	[1], [2], [3]
D0031		Alectinib	C30H34N4O2	49806720	Major		Inter Info	[1], [2], [3]
D0053		Ambrisentan	C22H22N2O4	6918493	Major		Inter Info	[1], [2], [3]
D0066		Amiodarone	C25H29I2NO3	2157	Major		Inter Info	[1], [2], [3]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Major		Inter Info	[3]
D0121		Atovaquone	C22H19ClO3	74989	Major		Inter Info	[1], [2], [3]
D0133		Axitinib	C22H18N4OS	6450551	Major		Inter Info	[1], [2], [3]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Major		Inter Info	[1], [2], [3]
D0153		Belinostat	C15H14N2O4S	6918638	Major		Inter Info	[3]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Major		Inter Info	[1], [2], [3]
D0182		Binimetinib	C17H15BrF2N4O3	10288191	Major		Inter Info	[1], [2], [3]
D0191		Blinatumomab	NA	NA	Major		Inter Info	[3]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Major		Inter Info	[3]
D0199		Brentuximab vedotin	NA	NA	Major		Inter Info	[3]
D0220		Bupropion	C13H18ClNO	444	Major		Inter Info	[1], [2], [3]
D0232		Calaspargase pegol	NA	NA	Major		Inter Info	[3]
D0248		Cannabidiol	C21H30O2	644019	Major		Inter Info	[1], [2], [3]
D0251		Capmatinib	C23H17FN6O	25145656	Major		Inter Info	[1], [2], [3]
D0254		Captopril	C9H15NO3S	44093	Major		Inter Info	[1], [2], [3]
D0261		Carfilzomib	C40H57N5O7	11556711	Major		Inter Info	[3]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Major		Inter Info	[1], [2], [3]
D0310		Chenodeoxycholic acid	C24H40O4	10133	Major		Inter Info	[1], [2], [3]
D0331		Choline salicylate	C12H19NO4	54686350	Major		Inter Info	[2], [3], [4]
D0349		Clarithromycin	C38H69NO13	84029	Major		Inter Info	[1], [2], [3]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Major		Inter Info	[3]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Major		Inter Info	[1], [2], [3]
D0416		Danazol	C22H27NO2	28417	Major		Inter Info	[1], [2], [3]
D0417		Dantrolene	C14H10N4O5	6914273	Major		Inter Info	[1], [2], [3]
D0426		Darunavir	C27H37N3O7S	213039	Major		Inter Info	[1], [2], [3]
D0432		Deferasirox	C21H15N3O4	214348	Major		Inter Info	[1], [2], [3]
D0499		Dimethyl fumarate	C6H8O4	637568	Major		Inter Info	[3]
D0507		Diroximel fumarate	C11H13NO6	73330464	Major		Inter Info	[3]
D0534		Dronedarone	C31H44N2O5S	208898	Major		Inter Info	[1], [2], [3]
D0543		Duvelisib	C22H17ClN6O	50905713	Major		Inter Info	[3]
D0555		Elagolix	C32H30F5N3O5	11250647	Major		Inter Info	[1], [2], [3]
D0560		Elotuzumab	NA	NA	Major		Inter Info	[3]
D0561		Eltrombopag	C25H22N4O4	135449332	Major		Inter Info	[1], [2], [3]
D0577		Entrectinib	C31H34F2N6O2	25141092	Major		Inter Info	[3]
D0637		Febuxostat	C16H16N2O3S	134018	Major		Inter Info	[1], [2], [3]
D0638		Fedratinib	C27H36N6O3S	16722836	Major		Inter Info	[1], [2], [3]
D0643		Fenofibric acid	C17H15ClO4	64929	Major		Inter Info	[1], [2], [3]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[3], [4], [12]
D0677		Fluoxymesterone	C20H29FO3	6446	Major		Inter Info	[1], [2], [3]
D0697		Fosphenytoin	C16H15N2O6P	56339	Major		Inter Info	[1], [2], [3]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Major		Inter Info	[1], [2], [3]
D0720		Gilteritinib	C29H44N8O3	49803313	Major		Inter Info	[1], [2], [3]
D0724		Givosiran	C78H139N11O30	119058042	Major		Inter Info	[1], [2], [3]
D0789		Idelalisib	C22H18FN7O	11625818	Major		Inter Info	[3]
D0805		Inotersen	C230H318N69O121P19S19	121492004	Major		Inter Info	[1], [2], [3]
D0806		Inotuzumab ozogamicin	NA	NA	Major		Inter Info	[3]
D0841		Ipilimumab	NA	NA	Major		Inter Info	[1], [2], [3]
D0869		Ivacaftor	C24H28N2O3	16220172	Major		Inter Info	[1], [2], [3]
D0874		Ixazomib	C14H19BCl2N2O4	25183872	Major		Inter Info	[3]
D0878		Kava	C14H16O3	5281052	Major		Inter Info	[1], [2], [3]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Major		Inter Info	[1], [2], [3]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Major		Inter Info	[1], [2], [3]
D0903		Lenvatinib	C21H19ClN4O4	9823820	Major		Inter Info	[1], [2], [3]
D0919		Levofloxacin	C18H20FN3O4	149096	Major		Inter Info	[1], [2], [3]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[1], [2], [3]
D0945		Lomustine	C9H16ClN3O2	3950	Major		Inter Info	[3]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Major		Inter Info	[3]
D0964		Lutetium Lu 177 dotatate	C65H87LuN14O19S2	76966897	Major		Inter Info	[3]
D0966		Macitentan	C19H20Br2N6O4S	16004692	Major		Inter Info	[1], [2], [3]
D0980		Maraviroc	C29H41F2N5O	3002977	Major		Inter Info	[1], [2], [3]
D1042		Methyltestosterone	C20H30O2	6010	Major		Inter Info	[1], [2], [3]
D1066		Milnacipran	C15H22N2O	65833	Major		Inter Info	[1], [2], [3]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[1], [2], [3]
D1085		Monomethyl fumarate	C5H6O4	5369209	Major		Inter Info	[3]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[1], [2], [3]
D1132		Nicotinamide	C6H6N2O	936	Major		Inter Info	[1], [2], [3]
D1139		Nintedanib	C31H33N5O4	135423438	Major		Inter Info	[1], [2], [3]
D1180		Onasemnogene abeparvovec	NA	NA	Major		Inter Info	[1], [2], [3]
D1207		Oxymetholone	C21H32O3	5281034	Major		Inter Info	[1], [2], [3]
D1221		Panobinostat	C21H23N3O2	6918837	Major		Inter Info	[3]
D1230		Pasireotide	C58H66N10O9	9941444	Major		Inter Info	[1], [2], [3]
D1232		Pazopanib	C21H23N7O2S	10113978	Major		Inter Info	[3]
D1239		Peginterferon beta-1a	NA	NA	Major		Inter Info	[1], [2], [3]
D1243		Pemoline	C9H8N2O2	4723	Major		Inter Info	[1], [2], [3]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[17]
D1261		Phenazopyridine	C11H11N5	4756	Major		Inter Info	[1], [2], [3]
D1272		Phenyl salicylate	C13H10O3	8361	Major		Inter Info	[2], [3], [4]
D1294		Pioglitazone	C19H20N2O3S	4829	Major		Inter Info	[1], [2], [3]
D1299		Pirfenidone	C12H11NO	40632	Major		Inter Info	[1], [2], [3]
D1301		Pitavastatin	C25H24FNO4	5282452	Major		Inter Info	[1], [2], [3]
D1306		Polatuzumab vedotin	NA	NA	Major		Inter Info	[3]
D1313		Ponatinib	C29H27F3N6O	24826799	Major		Inter Info	[3]
D1315		Posaconazole	C37H42F2N8O4	468595	Major		Inter Info	[1], [2], [3]
D1323		Pralatrexate	C23H23N7O5	148121	Major		Inter Info	[3]
D1327		Prasterone enantate	C26H40O3	163331	Major		Inter Info	[1], [2], [3]
D1387		Regorafenib	C21H15ClF4N4O3	11167602	Major		Inter Info	[1], [2], [3]
D1398		Ribociclib	C23H30N8O	44631912	Major		Inter Info	[3]
D1404		Rilpivirine	C22H18N6	6451164	Major		Inter Info	[1], [2], [3]
D1430		Rosuvastatin	C22H28FN3O6S	446157	Major		Inter Info	[9], [5], [2], [3]
D1442		Salsalate	C14H10O5	5161	Major		Inter Info	[2], [3], [4]
D1459		Selpercatinib	C29H31N7O3	134436906	Major		Inter Info	[1], [2], [3]
D1503		Stanozolol	C21H32N2O	25249	Major		Inter Info	[1], [2], [3]
D1522		Sunitinib	C22H27FN4O2	5329102	Major		Inter Info	[1], [2], [3]
D1531		Tagraxofusp	NA	NA	Major		Inter Info	[1], [2], [3]
D1608		Tolvaptan	C26H25ClN2O3	216237	Major		Inter Info	[1], [2], [3]
D1615		Trabectedin	C39H43N3O11S	108150	Major		Inter Info	[3]
D1623		Trastuzumab emtansine	NA	NA	Major		Inter Info	[1], [2], [3]
D1646		Trimetrexate	C19H23N5O3	5583	Major		Inter Info	[3]
D1653		Troleandomycin	C41H67NO15	202225	Major		Inter Info	[1], [2], [3]
D1660		Tucatinib	C26H24N8O2	51039094	Major		Inter Info	[1], [2], [3]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Major		Inter Info	[1], [2], [3]
D0902		Lenalidomide	C13H13N3O3	216326	Major		Inter Info	[3]
D0938		Lisinopril	C21H31N3O5	5362119	Major		Inter Info	[1], [2], [3]
D0988		Meclofenamic acid	C14H11Cl2NO2	4037	Major		Inter Info	[2], [3], [4]
D0991		Mefenamic acid	C15H15NO2	4044	Major		Inter Info	[2], [3], [4]
D0995		Meloxicam	C14H13N3O4S2	54677470	Major		Inter Info	[2], [3], [4]
D1003		Mephenytoin	C12H14N2O2	4060	Major		Inter Info	[1], [2], [3]
D1007		Mercaptopurine	C5H4N4S	667490	Major		Inter Info	[3]
D1014		Metaxalone	C12H15NO3	15459	Major		Inter Info	[1], [2], [3]
D1021		Methimazole	C4H6N2S	1349907	Major		Inter Info	[1], [2], [3]
D1025		Methotrexate	C20H22N8O5	126941	Major		Inter Info	[2], [3], [4]
D1035		Methyldopa	C10H13NO4	38853	Major		Inter Info	[1], [2], [3]
D1070		Minocycline	C23H27N3O7	54675783	Major		Inter Info	[1], [2], [3]
D1082		Moexipril	C27H34N2O7	91270	Major		Inter Info	[1], [2], [3]
D1092		Moxifloxacin	C21H24FN3O4	152946	Major		Inter Info	[1], [2], [3]
D1097		Nabumetone	C15H16O2	4409	Major		Inter Info	[2], [3], [4]
D1106		Naltrexone	C20H23NO4	5360515	Major		Inter Info	[1], [2], [3]
D1109		Naproxen	C14H14O3	156391	Major		Inter Info	[2], [3], [4]
D1129		Niacin	C6H5NO2	938	Major		Inter Info	[1], [2], [3]
D1137		Nilutamide	C12H10F3N3O4	4493	Major		Inter Info	[1], [2], [3]
D1145		Nitrofurantoin	C8H6N4O5	6604200	Major		Inter Info	[1], [2], [3]
D1187		Orlistat	C29H53NO5	3034010	Major		Inter Info	[1], [2], [3]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Major		Inter Info	[3]
D1195		Oxandrolone	C19H30O3	5878	Major		Inter Info	[1], [2], [3]
D1234		Pegaspargase	C14H19NO	436058	Major		Inter Info	[3]
D1237		Peginterferon alfa-2a	NA	NA	Major		Inter Info	[3]
D1238		Peginterferon alfa-2b	NA	NA	Major		Inter Info	[3]
D1256		Perindopril	C19H32N2O5	107807	Major		Inter Info	[1], [2], [3]
D1274		Phenylbutazone	C19H20N2O2	4781	Major		Inter Info	[2], [3], [4]
D1283		Phenytoin	C15H12N2O2	1775	Major		Inter Info	[1], [2], [3]
D1300		Piroxicam	C15H13N3O4S	54676228	Major		Inter Info	[2], [3], [4]
D1329		Pravastatin	C23H36O7	54687	Major		Inter Info	[1], [2], [3]
D1359		Propylthiouracil	C7H10N2OS	657298	Major		Inter Info	[1], [2], [3]
D1364		Pyrazinamide	C5H5N3O	1046	Major		Inter Info	[1], [2], [3]
D1369		Quinapril	C25H30N2O5	54892	Major		Inter Info	[1], [2], [3]
D1379		Ramipril	C23H32N2O5	5362129	Major		Inter Info	[1], [2], [3]
D1400		Rifampicin	C43H58N4O12	135398735	Major		Inter Info	[9], [5], [3]
D1405		Riluzole	C8H5F3N2OS	5070	Major		Inter Info	[1], [2], [3]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[1], [2], [3]
D1421		Rofecoxib	C17H14O4S	5090	Major		Inter Info	[2], [3], [4]
D1429		Rosiglitazone	C18H19N3O3S	77999	Major		Inter Info	[1], [2], [3]
D1439		Salicylic acid (sodium)	C7H6O3	338	Major		Inter Info	[2], [3], [4]
D1473		Simvastatin	C25H38O5	54454	Major		Inter Info	[1], [2], [3]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Major		Inter Info	[1], [2], [3]
D1504		Stavudine	C10H12N2O4	18283	Major		Inter Info	[1], [2], [3]
D1520		Sulindac	C20H17FO3S	1548887	Major		Inter Info	[2], [3], [4]
D1525		Tacrine	C13H14N2	1935	Major		Inter Info	[1], [2], [3]
D1553		Terbinafine	C21H25N	1549008	Major		Inter Info	[1], [2], [3]
D1558		Testosterone	C19H28O2	6013	Major		Inter Info	[1], [2], [3]
D1559		Testosterone (topical)	C19H28O2	6013	Major		Inter Info	[1], [2], [3]
D1589		Tioguanine	C5H5N5S	2723601	Major		Inter Info	[3]
D1604		Tolcapone	C14H11NO5	4659569	Major		Inter Info	[1], [2], [3]
D1606		Tolmetin	C15H15NO3	5509	Major		Inter Info	[2], [3], [4]
D1618		Trandolapril	C24H34N2O5	5484727	Major		Inter Info	[1], [2], [3]
D1626		Tretinoin	C20H28O2	444795	Major		Inter Info	[1], [2], [3]
D1652		Troglitazone	C24H27NO5S	5591	Major		Inter Info	[1], [2], [3]
D1657		Trovafloxacin	C20H15F3N4O3	62959	Major		Inter Info	[1], [2], [3]
D1674		Valdecoxib	C16H14N2O3S	119607	Major		Inter Info	[2], [3], [4]
D1677		Valproic acid	C8H16O2	3121	Major		Inter Info	[1], [2], [3]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Major		Inter Info	[3]
D1706		Voriconazole	C16H14F3N5O	71616	Major		Inter Info	[1], [2], [3]
D1714		Zafirlukast	C31H33N3O6S	5717	Major		Inter Info	[1], [2], [3]
D1715		Zalcitabine	C9H13N3O3	24066	Major		Inter Info	[1], [2], [3]
D1720		Zidovudine	C10H13N5O4	35370	Major		Inter Info	[3]
D1721		Zileuton	C11H12N2O2S	60490	Major		Inter Info	[1], [2], [3]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[9], [5], [43], [44], [45]
	Increased risk of peripheral neuropathy					Drug Num: 12
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[23], [24], [25]
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[23], [24], [25]
D0419		Dapsone	C12H12N2O2S	2955	Moderate		Inter Info	[23], [24], [25]
D0162		Benznidazole	C12H12N4O3	31593	Moderate		Inter Info	[23], [24], [25]
D0380		Colchicine	C22H25NO6	6167	Moderate		Inter Info	[23], [24], [25]
D0496		Diiodohydroxyquinoline	C9H5I2NO	3728	Moderate		Inter Info	[23], [24], [25]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[23], [24], [25]
D0770		Hydralazine	C8H8N4	3637	Moderate		Inter Info	[23], [24], [25]
D0918		Levodopa	C9H11NO4	6047	Moderate		Inter Info	[23], [24], [25]
D1543		Telbivudine	C10H14N2O5	159269	Moderate		Inter Info	[23], [24], [25]
D1051		Metronidazole	C6H9N3O3	4173	Moderate		Inter Info	[23], [24], [25]
D1587		Tinidazole	C8H13N3O4S	5479	Moderate		Inter Info	[23], [24], [25]
Pharmacodynamic antagonistic effects
	Antagonize the effect of vaccine/toxoid					Drug Num: 21
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1839		Measles virus vaccine live attenuated	NA	NA	Major		Inter Info	[13], [14], [15]
D1849		Mumps virus strain B level jeryl lynn live antigen	NA	NA	Major		Inter Info	[13], [14], [15]
D1881		Rotavirus vaccine	NA	NA	Major		Inter Info	[13], [14], [15]
D1882		Rubella virus vaccine	NA	NA	Major		Inter Info	[13], [14], [15]
D1890		Smallpox (Vaccinia) Vaccine, Live	NA	NA	Major		Inter Info	[19], [9], [20]
D1897		Talimogene laherparepvec	NA	NA	Major		Inter Info	[21]
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[13], [14], [15]
D1920		Varicella Zoster Vaccine (Recombinant)	NA	NA	Major		Inter Info	[13], [14], [15]
D1922		Yellow Fever Vaccine	NA	NA	Major		Inter Info	[13], [14], [15]
D0089		Anthrax vaccine	NA	NA	Moderate		Inter Info	[19], [31], [32]
D0366		Clostridium tetani toxoid antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[19], [31], [32]
D0755		Hepatitis A Vaccine	NA	NA	Moderate		Inter Info	[19], [31], [32]
D0756		Hepatitis B Vaccine (Recombinant)	NA	NA	Moderate		Inter Info	[19], [31], [32]
D0767		Human papillomavirus type 11 L1 capsid protein antigen	NA	NA	Moderate		Inter Info	[19], [31], [32]
D0803		Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)	NA	NA	Moderate		Inter Info	[19], [31], [32]
D0804		Influenza A virus A/Vietnam/1194/2004 (H5N1) antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[19], [31], [32]
D0999		Meningococcal polysaccharide vaccine group C	NA	NA	Moderate		Inter Info	[19], [31], [32]
D1307		Poliovirus type 1 antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[19], [31], [32]
D1662		Typhoid vaccine (inactivated)	NA	NA	Moderate		Inter Info	[19], [31], [32]
D1692		Vibrio cholerae CVD 103-HgR strain live antigen	NA	NA	Moderate		Inter Info	[19], [31], [32]
D1838		Lyme disease vaccine (recombinant OspA)	NA	NA	Moderate		Inter Info	[47]
	Antagonize the effect of probiotics					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1749		Bifidobacterium longum infantis	NA	NA	Moderate		Inter Info	[33], [34], [35]
D1827		Lactobacillus acidophilus	NA	NA	Moderate		Inter Info	[33], [34], [35]
	Diminish the response to diagnostic skin test antigens					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1755		Candida albicans	C29H27N2O12P	118855431	Moderate		Inter Info	[36], [37], [38]
D1765		Coccidioides immitis spherule	NA	NA	Moderate		Inter Info	[36], [37], [38]
D1912		Trichophyton mentagrophytes	NA	NA	Moderate		Inter Info	[36], [37], [38]
D1913		Tuberculin purified protein derivative	NA	NA	Moderate		Inter Info	[36], [37], [38]
	Antagonize the effects of immunosuppressants					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0545		Echinacea	NA	NA	Minor		Inter Info	[57], [58], [59]
D1722		Zinc acetate	C4H6O4Zn	11192	Minor		Inter Info	[57], [58], [59]
D1723		Zinc chloride	Cl2Zn	5727	Minor		Inter Info	[57], [58], [59]
D1724		Zinc gluconate	C12H22O14Zn	443445	Minor		Inter Info	[57], [58], [59]
D1725		Zinc sulfate	O4SZn	24424	Minor		Inter Info	[57], [58], [59]
D1703		Vitamin E	C29H50O2	14985	Minor		Inter Info	[57], [58], [59]

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