Drug General Information (ID: DDI4YBNUA7)
Drug Name			Leflunomide		Drug Info		Activated charcoal		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiinflammatory Agents				Antidotes
Structure

Mechanism of Leflunomide-Activated charcoal Interaction (Severity Level: Moderate)
Adsorption Click to Show/Hide Mechanism Graph
Drug Name		Leflunomide				Activated charcoal
Mechanism		Adsorbed by activated charcoal				Activated charcoal
Key Mechanism Factor 1
		Factor Name		Adsorption
		Factor Description		Adsorption is a direct drug interaction, usually through adsorption on its surface, resulting in reduced absorption of concomitantly administered drugs in the gastrointestinal tract.
Mechanism Description		Decreased absorption of Leflunomide due to adsorption of Activated charcoal

Recommended Action
Management		Coadministration of these drugs is not recommended.

References
1	Product Information. Arava (leflunomide). Hoechst Marion-Roussel Inc, Kansas City, MO.