Details of Drug

Drug General Information (ID: D0833)
Drug Name	Iohexol
Drug Type	Small molecule
Drug Synonymous	iohexol; 66108-95-0; Omnipaque; Nycodenz; Exypaque; Iohexolum; Omnipaque 240; Omnipaque 70; Omnipaque 140; Omnipaque 180; Omnipaque 210; Omnipaque 300; Omnipaque 350; WIN 39424; UNII-4419T9MX03; CHEBI:31709; N,N'-Bis(2,3-dihydroxypropyl)-5-(N-(2,3-dihydroxypropyl)acetamido)-2,4,6-triiodoisophthalamide; 5-[acetyl(2,3-dihydroxypropyl)amino]-1-N,3-N-bis(2,3-dihydroxypropyl)-2,4,6-triiodobenzene-1,3-dicarboxamide; WIN-39424; 5-[Acetyl(2,3-dihydroxypropyl)amino]-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide; N1,N3-bis(2,3-dihydroxypropyl)-5-(N-(2,3-dihydroxypropyl)acetamido)-2,4,6-triiodoisophthalamide; 4419T9MX03; 1,3-Benzenedicarboxamide, 5-(acetyl(2,3-dihydroxypropyl)amino)-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-; NCGC00166000-01; DSSTox_CID_3157; 5-(N-2,3-Dihydroxypropylacetamido)-2,4,6-triiodo-N,N'-bis(2,3-dihydroxypropyl)isophthalamide; DSSTox_RID_76895; DSSTox_GSID_23157; Histodenz; Iohexolum [INN-Latin]; 5-[acetyl(2,3-dihydroxypropyl)amino]-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodobenzene-1,3-dicarboxamide; 5-[N-(2,3-Dihydroxypropyl)acetamido]-2,4,6-triiodo-N,N'-bis(2,3-dihydroxypropyl)isophthalamide; SMR000857075; EINECS 266-164-2; BRN 2406632; Oraltag; C19H26I3N3O9; Omnipaque (TN); 1,3-benzenedicarboxamide, 5-[acetyl(2,3-dihydroxypropyl)amino]-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-; n,n'-bis(2,3-dihydroxypropyl)-5-[n-(2,3-dihydroxypropyl)acetamido]-2,4,6-triiodoisophthalamide; Prestwick_802; CAS-66108-95-0; Iohexol [USAN:USP:INN:BAN:JAN]; Histodenz; ; ; Nycodenz; Prestwick0_000512; Prestwick1_000512; Prestwick2_000512; Prestwick3_000512; Nycodenz;Omnipaque;Exypaque; EC 266-164-2; Iohexol, analytical standard; SCHEMBL26501; BSPBio_000463; MLS001332585; MLS001332586; MLS002153854; Iohexol (JP17/USP/INN); SPBio_002384; BPBio1_000511; CHEMBL1200455; DTXSID6023157; BCBcMAP01_000051; HMS1569H05; HMS2096H05; HMS2235D07; HMS3369O04; HMS3713H05; ALBB-028959; AMY21804; BCP31800; HY-B0594; Tox21_112286; BDBM50247977; MFCD00077732; s4531; AKOS015895399; Tox21_112286_1; AC-1934; CCG-220512; DB01362; NSC 759636; SMP1_000152; NCGC00166000-02; NCGC00166000-04; AS-12699; FT-0627276; I0903; D01817; D91214; Histodenz(TM), nonionic density gradient medium; 108I950; A835339; Q410683; SR-01000838892; SR-01000838892-2; Iohexol, European Pharmacopoeia (EP) Reference Standard; Iohexol, United States Pharmacopeia (USP) Reference Standard; 5-(N-dhp-acetamido)-2,4,6-triiodo-N,N'-B is-dhp-isophthalami; Iohexol, Pharmaceutical Secondary Standard; Certified Reference Material; Iohexol for peak identification, European Pharmacopoeia (EP) Reference Standard; 1,3-Benzenedicarboxamide, 5-[acetyl(2,3-dihydroxypropyl)amino]-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-; 1-N,3-N-bis(2,3-dihydroxypropyl)-5-[N-(2,3-dihydroxypropyl)acetamido]-2,4,6-triiodobenzene-1,3-dicarboxamide; 5-[acetyl(2,3-dihydroxypropyl)amino]-N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodobenzene-1,3-dicarboxamide; N1,N3-bis(2,3-dihydroxypropyl)-5-[N-(2,3-dihydroxypropyl)acetamido]-2,4,6-triiodobenzene-1,3-dicarboxamide; N1,N3-bis[2,3-bis(oxidanyl)propyl]-5-[2,3-bis(oxidanyl)propyl-ethanoyl-amino]-2,4,6-tris(iodanyl)benzene-1,3-dicarboxamide Click to Show/Hide
Therapeutic Class	Non-Ionic Iodinated Contrast Media
Structure
Structure	3D Structure		2D Structure
Formula	C19H26I3N3O9
InChI	InChI=1S/C19H26I3N3O9/c1-8(29)25(4-11(32)7-28)17-15(21)12(18(33)23-2-9(30)5-26)14(20)13(16(17)22)19(34)24-3-10(31)6-27/h9-11,26-28,30-32H,2-7H2,1H3,(H,23,33)(H,24,34)
InChIKey	NTHXOOBQLCIOLC-UHFFFAOYSA-N
Canonical SMILES	CC(=O)N(CC(CO)O)C1=C(C(=C(C(=C1I)C(=O)NCC(CO)O)I)C(=O)NCC(CO)O)I
External Link
External Link	Pubchem ID	3730

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM003 Affected organization distribution AM005 Affected excretion pathways AM006 Pharmacodynamic additive effects BM014 Interference of cell/tissue uptake BM027 Decreased renal excretion due to nephrotoxicity BM069 Increased risk of lowers seizure threshold BM072 Increased risk of nephrotoxicity BM081 Increased risk of ventricular arrhythmias BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Iohexol
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1822		Iodide I-123	I-	135300	Moderate		Inter Info	[24], [25], [26]
Affected excretion pathways
	Decreased renal excretion due to nephrotoxicity					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1015		Metformin	C4H11N5	4091	Major		Inter Info	[15], [16], [17], [18], [19]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[24], [28], [29], [30], [31]
Pharmacodynamic additive effects
	Increased risk of lowers seizure threshold					Drug Num: 171
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0030		Aldesleukin	NA	NA	Major		Inter Info	[8], [9]
D0035		Alfentanil	C21H32N6O3	51263	Major		Inter Info	[10], [11], [12], [13], [8]
D0037		Alimemazine	C18H22N2S	5574	Major		Inter Info	[11], [13], [12]
D0051		Amantadine	C10H17N	2130	Major		Inter Info	[10], [11], [12], [13], [8]
D0064		Aminophylline	C16H24N10O4	9433	Major		Inter Info	[10], [11], [12], [13], [8]
D0068		Amitriptyline	C20H23N	2160	Major		Inter Info	[10], [11], [12], [13], [8]
D0072		Amoxapine	C17H16ClN3O	2170	Major		Inter Info	[10], [11], [12], [13], [8]
D0074		Amphetamine	C9H13N	3007	Major		Inter Info	[10], [11], [12], [13], [8]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Major		Inter Info	[10], [11], [12], [13], [8]
D0165		Benzphetamine	C17H21N	5311017	Major		Inter Info	[10], [11], [12], [13], [8]
D0175		Bethanechol	C7H17N2O2+	2370	Major		Inter Info	[10], [11], [12], [13], [8]
D0219		Buprenorphine	C29H41NO4	644073	Major		Inter Info	[10], [11], [12], [13], [8]
D0220		Bupropion	C13H18ClNO	444	Major		Inter Info	[10], [11], [12], [13], [8]
D0226		Butorphanol	C21H29NO2	5361092	Major		Inter Info	[10], [11], [12], [13], [8]
D0320		Chloroquine	C18H26ClN3	2719	Major		Inter Info	[10], [11], [12], [13], [8]
D0324		Chlorpromazine	C17H19ClN2S	2726	Major		Inter Info	[10], [11], [12], [13], [8]
D0340		Cinoxacin	C12H10N2O5	2762	Major		Inter Info	[10], [11], [12], [13], [8]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Major		Inter Info	[10], [11], [12], [13], [8]
D0345		Citalopram	C20H21FN2O	2771	Major		Inter Info	[10], [11], [12], [13], [8]
D0361		Clomipramine	C19H23ClN2	2801	Major		Inter Info	[10], [11], [12], [13], [8]
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[10], [11], [12], [13], [8]
D0377		Cocaine (nasal)	C17H21NO4	446220	Major		Inter Info	[11], [13], [12]
D0379		Codeine	C18H21NO3	5284371	Major		Inter Info	[10], [11], [12], [13], [8]
D0398		Cyclobenzaprine	C20H21N	2895	Major		Inter Info	[10], [11], [12], [13], [8]
D0401		Cycloserine	C3H6N2O2	6234	Major		Inter Info	[10], [11], [12], [13], [8]
D0446		Desipramine	C18H22N2	2995	Major		Inter Info	[10], [11], [12], [13], [8]
D0457		Dexfenfluramine	C12H16F3N	66265	Major		Inter Info	[10], [11], [12], [13], [8]
D0467		Dextropropoxyphene	C22H29NO2	10100	Major		Inter Info	[11], [13], [12]
D0470		Dezocine	C16H23NO	3033053	Major		Inter Info	[10], [11], [12], [13], [8]
D0486		Diethylpropion	C13H19NO	7029	Major		Inter Info	[10], [11], [12], [13], [8]
D0516		Donepezil	C24H29NO3	3152	Major		Inter Info	[10], [11], [12], [13], [8]
D0523		Doxapram	C24H30N2O2	3156	Major		Inter Info	[10], [11], [12], [13], [8]
D0525		Doxepin	C19H21NO	667477	Major		Inter Info	[10], [11], [12], [13], [8]
D0526		Doxepin (topical)	C19H21NO	667477	Major		Inter Info	[11], [13], [12]
D0533		Dronabinol	C21H30O2	16078	Major		Inter Info	[10], [11], [12], [13], [8]
D0539		Duloxetine	C18H19NOS	60835	Major		Inter Info	[10], [11], [12], [13], [8]
D0573		Enoxacin	C15H17FN4O3	3229	Major		Inter Info	[10], [11], [12], [13], [8]
D0596		Ertapenem	C22H25N3O7S	150610	Major		Inter Info	[10], [11], [12], [13], [8]
D0599		Escitalopram	C20H21FN2O	146570	Major		Inter Info	[10], [11], [12], [13], [8]
D0641		Fenfluramine	C12H16F3N	3337	Major		Inter Info	[10], [11], [12], [13], [8]
D0646		Fentanyl	C22H28N2O	3345	Major		Inter Info	[10], [11], [12], [13], [8]
D0676		Fluoxetine	C17H18F3NO	3386	Major		Inter Info	[10], [11], [12], [13], [8]
D0678		Fluphenazine	C22H26F3N3OS	3372	Major		Inter Info	[10], [11], [12], [13], [8]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Major		Inter Info	[10], [11], [12], [13], [8]
D0707		Galantamine	C17H21NO3	9651	Major		Inter Info	[10], [11], [12], [13], [8]
D0712		Gatifloxacin	C19H22FN3O4	5379	Major		Inter Info	[10], [11], [12], [13], [8]
D0716		Gemifloxacin	C18H20FN5O4	9571107	Major		Inter Info	[10], [11], [12], [13], [8]
D0740		Grepafloxacin	C19H22FN3O3	72474	Major		Inter Info	[10], [11], [12], [13], [8]
D0750		Haloperidol	C21H23ClFNO2	3559	Major		Inter Info	[10], [11], [12], [13], [8]
D0772		Hydrocodone	C18H21NO3	5284569	Major		Inter Info	[10], [11], [12], [13], [8]
D0776		Hydromorphone	C17H19NO3	5284570	Major		Inter Info	[10], [11], [12], [13], [8]
D0795		Imipramine	C19H24N2	3696	Major		Inter Info	[10], [11], [12], [13], [8]
D0821		Interferon alfa-2a, Recombinant	NA	NA	Major		Inter Info	[11], [13], [12]
D0822		Interferon alfa-2b	C16H17Cl3I2N3NaO5S	71306834	Major		Inter Info	[10], [11], [12], [13], [8]
D0824		Interferon alfa-n1	NA	NA	Major		Inter Info	[10], [11], [12], [13], [8]
D0825		Interferon alfa-n3	NA	NA	Major		Inter Info	[10], [11], [12], [13], [8]
D0823		Interferon alfacon-1	NA	NA	Major		Inter Info	[10], [11], [12], [13], [8]
D0826		Interferon beta-1a	NA	NA	Major		Inter Info	[10], [11], [12], [13], [8]
D0827		Interferon beta-1b	NA	NA	Major		Inter Info	[10], [11], [12], [13], [8]
D0828		Interferon gamma-1b	NA	NA	Major		Inter Info	[10], [11], [12], [13], [8]
D0054		Amifampridine	C5H7N3	5918	Major		Inter Info	[10], [11], [12], [13], [8]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Major		Inter Info	[10], [11], [12], [13], [8]
D0112		Asenapine	C17H16ClNO	3036780	Major		Inter Info	[10], [11], [12], [13], [8]
D0161		Benzhydrocodone	C25H25NO4	49836084	Major		Inter Info	[11], [13], [12]
D0191		Blinatumomab	NA	NA	Major		Inter Info	[10], [11], [12], [13], [8]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Major		Inter Info	[10], [11], [12], [13], [8]
D0280		Cefiderocol	C30H34ClN7O10S2	77843966	Major		Inter Info	[10], [11], [12], [13], [8]
D0412		Dalfampridine	C5H6N2	1727	Major		Inter Info	[10], [11], [12], [13], [8]
D0438		Delafloxacin	C18H12ClF3N4O4	487101	Major		Inter Info	[10], [11], [12], [13], [8]
D0451		Desvenlafaxine	C16H25NO2	125017	Major		Inter Info	[10], [11], [12], [13], [8]
D0460		Dexmethylphenidate	C14H19NO2	154101	Major		Inter Info	[10], [11], [12], [13], [8]
D0465		Dextroamphetamine	C9H13N	5826	Major		Inter Info	[10], [11], [12], [13], [8]
D0471		Diamorphine	C21H23NO5	5462328	Major		Inter Info	[11], [13], [12]
D0493		Dihydrocodeine	C18H23NO3	5284543	Major		Inter Info	[11], [13], [12]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Major		Inter Info	[10], [11], [12], [13], [8]
D0579		Ephedrine	C10H15NO	9294	Major		Inter Info	[10], [11], [12], [13], [8]
D0791		Iloperidone	C24H27FN2O4	71360	Major		Inter Info	[10], [11], [12], [13], [8]
D0794		Imipenem	C12H17N3O4S	104838	Major		Inter Info	[11], [13], [12]
D0920		Levomilnacipran	C15H22N2O	6917779	Major		Inter Info	[10], [11], [12], [13], [8]
D0959		Lumateperone	C24H28FN3O	21302490	Major		Inter Info	[10], [11], [12], [13], [8]
D0961		Lurasidone	C28H36N4O2S	213046	Major		Inter Info	[10], [11], [12], [13], [8]
D1012		Metamfetamine	C10H15N	10836	Major		Inter Info	[11], [13], [12]
D1026		Methotrimeprazine	C19H24N2OS	72287	Major		Inter Info	[10], [11], [12], [13], [8]
D1066		Milnacipran	C15H22N2O	65833	Major		Inter Info	[10], [11], [12], [13], [8]
D1084		Molindone	C16H24N2O2	23897	Major		Inter Info	[10], [11], [12], [13], [8]
D1122		Neostigmine	C12H19N2O2+	4456	Major		Inter Info	[10], [11], [12], [13], [8]
D1169		Oliceridine	C22H30N2O2S	66553195	Major		Inter Info	[10], [11], [12], [13], [8]
D1183		Opium	NA	NA	Major		Inter Info	[10], [11], [12], [13], [8]
D1239		Peginterferon beta-1a	NA	NA	Major		Inter Info	[10], [11], [12], [13], [8]
D1262		Phendimetrazine	C12H17NO	30487	Major		Inter Info	[10], [11], [12], [13], [8]
D1535		Tapentadol	C14H23NO	9838022	Major		Inter Info	[10], [11], [12], [13], [8]
D1576		Thiothixene	C23H29N3O2S2	941651	Major		Inter Info	[10], [11], [12], [13], [8]
D1696		Vilazodone	C26H27N5O2	6918314	Major		Inter Info	[10], [11], [12], [13], [8]
D1708		Vortioxetine	C18H22N2S	9966051	Major		Inter Info	[10], [11], [12], [13], [8]
D0853		Isocarboxazid	C12H13N3O2	3759	Major		Inter Info	[10], [11], [12], [13], [8]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[11], [13], [12]
D0919		Levofloxacin	C18H20FN3O4	149096	Major		Inter Info	[10], [11], [12], [13], [8]
D0923		Levorphanol	C17H23NO	5359272	Major		Inter Info	[10], [11], [12], [13], [8]
D0927		Lidocaine	C14H22N2O	3676	Major		Inter Info	[10], [11], [12], [13], [8]
D0932		Lindane	C6H6Cl6	727	Major		Inter Info	[11], [13], [12]
D0937		Lisdexamfetamine	C15H25N3O	11597698	Major		Inter Info	[10], [11], [12], [13], [8]
D0943		Lomefloxacin	C17H19F2N3O3	3948	Major		Inter Info	[10], [11], [12], [13], [8]
D0957		Loxapine	C18H18ClN3O	3964	Major		Inter Info	[10], [11], [12], [13], [8]
D0979		Maprotiline	C20H23N	4011	Major		Inter Info	[10], [11], [12], [13], [8]
D0981		Mazindol	C16H13ClN2O	4020	Major		Inter Info	[10], [11], [12], [13], [8]
D0992		Mefloquine	C17H16F6N2O	4046	Major		Inter Info	[10], [11], [12], [13], [8]
D1001		Meperidine	C15H21NO2	4058	Major		Inter Info	[10], [11], [12], [13], [8]
D1008		Meropenem	C17H25N3O5S	441130	Major		Inter Info	[10], [11], [12], [13], [8]
D1010		Mesoridazine	C21H26N2OS2	4078	Major		Inter Info	[10], [11], [12], [13], [8]
D1017		Methadone	C21H27NO	4095	Major		Inter Info	[10], [11], [12], [13], [8]
D1019		Methdilazine	C18H20N2S	14677	Major		Inter Info	[10], [11], [12], [13], [8]
D1039		Methylphenidate	C14H19NO2	4158	Major		Inter Info	[10], [11], [12], [13], [8]
D1046		Metoclopramide	C14H22ClN3O2	4168	Major		Inter Info	[10], [11], [12], [13], [8]
D1054		Mexiletine	C11H17NO	4178	Major		Inter Info	[10], [11], [12], [13], [8]
D1075		Mirtazapine	C17H19N3	4205	Major		Inter Info	[10], [11], [12], [13], [8]
D1089		Morphine	C17H19NO3	5288826	Major		Inter Info	[10], [11], [12], [13], [8]
D1090		Morphine (liposomal)	C17H19NO3	5288826	Major		Inter Info	[11], [13], [12]
D1092		Moxifloxacin	C21H24FN3O4	152946	Major		Inter Info	[10], [11], [12], [13], [8]
D1093		Muromonab	NA	NA	Major		Inter Info	[11], [13], [12]
D1100		Nalbuphine	C21H27NO4	5311304	Major		Inter Info	[10], [11], [12], [13], [8]
D1102		Nalidixic acid	C12H12N2O3	4421	Major		Inter Info	[10], [11], [12], [13], [8]
D1117		Nefazodone	C25H32ClN5O2	4449	Major		Inter Info	[10], [11], [12], [13], [8]
D1118		Nelarabine	C11H15N5O5	3011155	Major		Inter Info	[10], [11], [12], [13], [8]
D1155		Norfloxacin	C16H18FN3O3	4539	Major		Inter Info	[10], [11], [12], [13], [8]
D1158		Nortriptyline	C19H21N	4543	Major		Inter Info	[10], [11], [12], [13], [8]
D1165		Ofloxacin	C18H20FN3O4	4583	Major		Inter Info	[10], [11], [12], [13], [8]
D1166		Olanzapine	C17H20N4S	135398745	Major		Inter Info	[10], [11], [12], [13], [8]
D1194		Oxamniquine	C14H21N3O3	4612	Major		Inter Info	[10], [11], [12], [13], [8]
D1201		Oxtriphylline	C12H21N5O3	656652	Major		Inter Info	[10], [11], [12], [13], [8]
D1203		Oxycodone	C18H21NO4	5284603	Major		Inter Info	[10], [11], [12], [13], [8]
D1208		Oxymorphone	C17H19NO4	5284604	Major		Inter Info	[10], [11], [12], [13], [8]
D1215		Paliperidone	C23H27FN4O3	115237	Major		Inter Info	[10], [11], [12], [13], [8]
D1229		Paroxetine	C19H20FNO3	43815	Major		Inter Info	[10], [11], [12], [13], [8]
D1237		Peginterferon alfa-2a	NA	NA	Major		Inter Info	[10], [11], [12], [13], [8]
D1238		Peginterferon alfa-2b	NA	NA	Major		Inter Info	[10], [11], [12], [13], [8]
D1243		Pemoline	C9H8N2O2	4723	Major		Inter Info	[10], [11], [12], [13], [8]
D1247		Pentazocine	C19H27NO	441278	Major		Inter Info	[10], [11], [12], [13], [8]
D1257		Perphenazine	C21H26ClN3OS	4748	Major		Inter Info	[10], [11], [12], [13], [8]
D1263		Phenelzine	C8H12N2	3675	Major		Inter Info	[10], [11], [12], [13], [8]
D1270		Phentermine	C10H15N	4771	Major		Inter Info	[10], [11], [12], [13], [8]
D1281		Phenylpropanolamine	C9H13NO	26934	Major		Inter Info	[10], [11], [12], [13], [8]
D1285		Physostigmine	C15H21N3O2	5983	Major		Inter Info	[10], [11], [12], [13], [8]
D1292		Pimozide	C28H29F2N3O	16362	Major		Inter Info	[10], [11], [12], [13], [8]
D1297		Piperazine	C4H10N2	4837	Major		Inter Info	[10], [11], [12], [13], [8]
D1346		Prochlorperazine	C20H24ClN3S	4917	Major		Inter Info	[10], [11], [12], [13], [8]
D1351		Promazine	C17H20N2S	4926	Major		Inter Info	[10], [11], [12], [13], [8]
D1352		Promethazine	C17H20N2S	4927	Major		Inter Info	[10], [11], [12], [13], [8]
D1355		Propiomazine	C20H24N2OS	4940	Major		Inter Info	[10], [11], [12], [13], [8]
D1361		Protriptyline	C19H21N	4976	Major		Inter Info	[10], [11], [12], [13], [8]
D1368		Quetiapine	C21H25N3O2S	5002	Major		Inter Info	[10], [11], [12], [13], [8]
D1390		Remifentanil	C20H28N2O5	60815	Major		Inter Info	[10], [11], [12], [13], [8]
D1406		Rimantadine	C12H21N	5071	Major		Inter Info	[10], [11], [12], [13], [8]
D1413		Risperidone	C23H27FN4O2	5073	Major		Inter Info	[10], [11], [12], [13], [8]
D1418		Rivastigmine	C14H22N2O2	77991	Major		Inter Info	[10], [11], [12], [13], [8]
D1461		Sertraline	C17H17Cl2N	68617	Major		Inter Info	[10], [11], [12], [13], [8]
D1464		Sibutramine	C17H26ClN	5210	Major		Inter Info	[10], [11], [12], [13], [8]
D1499		Sparfloxacin	C19H22F2N4O3	60464	Major		Inter Info	[10], [11], [12], [13], [8]
D1512		Sufentanil	C22H30N2O2S	41693	Major		Inter Info	[10], [11], [12], [13], [8]
D1525		Tacrine	C13H14N2	1935	Major		Inter Info	[10], [11], [12], [13], [8]
D1570		Theophylline	C7H8N4O2	2153	Major		Inter Info	[10], [11], [12], [13], [8]
D1572		Thiethylperazine	C22H29N3S2	5440	Major		Inter Info	[10], [11], [12], [13], [8]
D1574		Thioridazine	C21H26N2S2	5452	Major		Inter Info	[10], [11], [12], [13], [8]
D1616		Tramadol	C16H25NO2	33741	Major		Inter Info	[10], [11], [12], [13], [8]
D1620		Tranylcypromine	C9H11N	19493	Major		Inter Info	[10], [11], [12], [13], [8]
D1624		Trazodone	C19H22ClN5O	5533	Major		Inter Info	[10], [11], [12], [13], [8]
D1637		Trifluoperazine	C21H24F3N3S	5566	Major		Inter Info	[10], [11], [12], [13], [8]
D1638		Triflupromazine	C18H19F3N2S	5568	Major		Inter Info	[10], [11], [12], [13], [8]
D1647		Trimipramine	C20H26N2	5584	Major		Inter Info	[10], [11], [12], [13], [8]
D1657		Trovafloxacin	C20H15F3N4O3	62959	Major		Inter Info	[10], [11], [12], [13], [8]
D1689		Venlafaxine	C17H27NO2	5656	Major		Inter Info	[10], [11], [12], [13], [8]
D1726		Ziprasidone	C21H21ClN4OS	60854	Major		Inter Info	[10], [11], [12], [13], [8]
	Increased risk of nephrotoxicity					Drug Num: 101
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0022		Acyclovir	C8H11N5O3	135398513	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0056		Amikacin	C22H43N5O13	37768	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0057		Amikacin (liposome)	C22H43N5O13	37768	Major		Inter Info	[3], [4], [5]
D0075		Amphotericin B	C47H73NO17	5280965	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0076		Amphotericin B (cholesteryl sulfate)	C47H73NO17	5280965	Major		Inter Info	[3], [4], [5]
D0077		Amphotericin B (lipid complex)	C47H73NO17	5280965	Major		Inter Info	[3], [4], [5]
D0078		Amphotericin B (liposomal)	C47H73NO17	5280965	Major		Inter Info	[3], [4], [5]
D0142		Bacitracin	C66H103N17O16S	10909430	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0145		Balsalazide	C17H15N3O6	54585	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0210		Bromfenac	C15H12BrNO3	60726	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0298		Celecoxib	C17H14F3N3O2S	2662	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0335		Cidofovir	C8H14N3O6P	60613	Major		Inter Info	[14]
D0344		Cisplatin	Cl2H6N2Pt	5702198	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0357		Clofarabine	C10H11ClFN5O3	119182	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0383		Colistimethate	C58H105N16O28S5-5	70789202	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0402		Cyclosporine	C62H111N11O12	5284373	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0434		Deferoxamine	C25H48N6O8	2973	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0476		Diclofenac	C14H11Cl2NO2	3033	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0489		Diflunisal	C13H8F2O3	3059	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0623		Etidronic acid	C2H8O7P2	3305	Major		Inter Info	[3], [4], [5]
D0624		Etodolac	C17H21NO3	3308	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0645		Fenoprofen	C15H14O3	3342	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0680		Flurbiprofen	C15H13FO2	3394	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0694		Foscarnet	CH3O5P	3415	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0718		Gentamicin	C21H43N5O7	3467	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0783		Ibandronate	C9H23NO7P2	60852	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0786		Ibuprofen	C13H18O2	3672	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0790		Ifosfamide	C7H15Cl2N2O2P	3690	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0800		Indomethacin	C19H16ClNO4	3715	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0432		Deferasirox	C21H15N3O4	214348	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0549		Edetate calcium disodium anhydrous	C10H12CaN2Na2O8	6093170	Major		Inter Info	[3], [4], [5]
D0550		Edetate disodium anhydrous	C10H14N2Na2O8	8759	Major		Inter Info	[3], [4], [5]
D0629		Everolimus	C53H83NO14	6442177	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0709		Gallium nitrate	GaN3O9	61635	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0724		Givosiran	C78H139N11O30	119058042	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0805		Inotersen	C230H318N69O121P19S19	121492004	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0829		Iobenguane (I-131)	C8H10IN3	60860	Major		Inter Info	[3], [4], [5]
D0940		Lithium carbonate	CLi2O3	11125	Major		Inter Info	[3], [4], [5]
D0964		Lutetium Lu 177 dotatate	C65H87LuN14O19S2	76966897	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1091		Moxetumomab Pasudotox	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1304		Plazomicin	C25H48N6O10	42613186	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1442		Salsalate	C14H10O5	5161	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1542		Telavancin	C80H106Cl2N11O27P	3081362	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1549		Temsirolimus	C56H87NO16	6918289	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0876		Kanamycin	C18H36N4O11	6032	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0881		Ketoprofen	C16H14O3	3825	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0882		Ketorolac	C15H13NO3	3826	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0988		Meclofenamic acid	C14H11Cl2NO2	4037	Major		Inter Info	[3], [4], [5]
D0991		Mefenamic acid	C15H15NO2	4044	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0995		Meloxicam	C14H13N3O4S2	54677470	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1009		Mesalazine	C7H7NO3	4075	Major		Inter Info	[3], [4], [5]
D1030		Methoxyflurane	C3H4Cl2F2O	4116	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1097		Nabumetone	C15H16O2	4409	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1109		Naproxen	C14H14O3	156391	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1120		Neomycin	C23H46N6O13	8378	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1126		Netilmicin	C21H41N5O7	441306	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1173		Olsalazine	C14H10N2O6	22419	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1196		Oxaprozin	C18H15NO3	4614	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1217		Pamidronic acid	C3H11NO7P2	4674	Major		Inter Info	[3], [4], [5]
D1245		Penicillamine	C5H11NO2S	5852	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1246		Pentamidine	C19H24N4O2	4735	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1274		Phenylbutazone	C19H20N2O2	4781	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1300		Piroxicam	C15H13N3O4S	54676228	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1310		Polymyxin B	C56H98N16O13	49800004	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1421		Rofecoxib	C17H14O4S	5090	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1476		Sirolimus	C51H79NO13	5284616	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1507		Streptomycin	C21H39N7O12	19649	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1508		Streptozocin	C8H15N3O7	29327	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1517		Sulfasalazine	C18H14N4O5S	5339	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1520		Sulindac	C20H17FO3S	1548887	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1526		Tacrolimus	C44H69NO12	445643	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1597		Tobramycin	C18H37N5O9	36294	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1606		Tolmetin	C15H15NO3	5509	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1672		Valaciclovir	C13H20N6O4	135398742	Major		Inter Info	[3], [4], [5]
D1674		Valdecoxib	C16H14N2O3S	119607	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1680		Vancomycin	C66H75Cl2N9O24	14969	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D1727		Zoledronic acid	C5H10N2O7P2	68740	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7]
D0012		Acetazolamide	C4H6N4O3S2	1986	Moderate		Inter Info	[20], [21], [22]
D0058		Amiloride	C6H8ClN7O	16231	Moderate		Inter Info	[20], [21], [22]
D0158		Bendroflumethiazide	C15H14F3N3O4S2	2315	Moderate		Inter Info	[20], [21], [22]
D0166		Benzthiazide	C15H14ClN3O4S3	2343	Moderate		Inter Info	[20], [21], [22]
D0217		Bumetanide	C17H20N2O5S	2471	Moderate		Inter Info	[20], [21], [22]
D0321		Chlorothiazide	C7H6ClN3O4S2	2720	Moderate		Inter Info	[20], [21], [22]
D0326		Chlorthalidone	C14H11ClN2O4S	2732	Moderate		Inter Info	[20], [21], [22]
D0479		Diclofenamide	C6H6Cl2N2O4S2	3038	Moderate		Inter Info	[20], [21], [22]
D0613		Etacrynic acid	C13H12Cl2O4	3278	Moderate		Inter Info	[20], [21], [22]
D0704		Furosemide	C12H11ClN2O5S	3440	Moderate		Inter Info	[20], [21], [22]
D0771		Hydrochlorothiazide	C7H8ClN3O4S2	3639	Moderate		Inter Info	[20], [21], [22]
D0775		Hydroflumethiazide	C8H8F3N3O4S2	3647	Moderate		Inter Info	[20], [21], [22]
D0798		Indapamide	C16H16ClN3O3S	3702	Moderate		Inter Info	[20], [21], [22]
D1826		Iopanoic acid	C11H12I3NO2	3735	Moderate		Inter Info	[18], [26], [27]
D1915		Tyropanoic acid	C15H18I3NO3	5611	Moderate		Inter Info	[18], [26], [27]
D1668		Urea	CH4N2O	1176	Moderate		Inter Info	[20], [21], [22]
D0978		Mannitol	C6H14O6	6251	Moderate		Inter Info	[20], [21], [22]
D1018		Methazolamide	C5H8N4O3S2	4100	Moderate		Inter Info	[20], [21], [22]
D1048		Metolazone	C16H16ClN3O3S	4170	Moderate		Inter Info	[20], [21], [22]
D1311		Polythiazide	C11H13ClF3N3O4S3	4870	Moderate		Inter Info	[20], [21], [22]
D1501		Spironolactone	C24H32O4S	5833	Moderate		Inter Info	[20], [21], [22]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[20], [21], [22]
D1631		Triamterene	C12H11N7	5546	Moderate		Inter Info	[20], [21], [22]
D1633		Trichlormethiazide	C8H8Cl3N3O4S2	5560	Moderate		Inter Info	[20], [21], [22]
	Increased risk of ventricular arrhythmias					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[23]
D0508		Disopyramide	C21H29N3O	3114	Moderate		Inter Info	[23]
D0513		Dofetilide	C19H27N3O5S2	71329	Moderate		Inter Info	[23]
D0787		Ibutilide	C20H36N2O3S	60753	Moderate		Inter Info	[23]
D1343		Procainamide	C13H21N3O	4913	Moderate		Inter Info	[23]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[23]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0172		Betamethasone	C22H29FO5	9782	Major		Inter Info	[10], [11], [8]
D0453		Dexamethasone	C22H29FO5	5743	Major		Inter Info	[10], [11], [8]
D0773		Hydrocortisone	C21H30O5	5754	Major		Inter Info	[10], [11], [8]
D1041		Methylprednisolone	C22H30O5	6741	Major		Inter Info	[10], [11], [8]
D1332		Prednisolone	C21H28O5	5755	Major		Inter Info	[10], [11], [8]
D1628		Triamcinolone	C21H27FO6	31307	Major		Inter Info	[10], [11], [8]

References
1	Wong GT, Lee EY, Irwin MG. Contrast induced nephropathy in vascular surgery.?Br J Anaesth. 2016;117 Suppl 2:ii63-ii73. [PMID: 27566809]
2	Bennett WM, Porter GA "Nephrotoxicity of common drugs used by urologists." Urol Clin North Am 17 (1990): 145-56. [PMID: 2407013]
3	Bentley ML, Corwin HL, Dasta J "Drug-induced acute kidney injury in the critically ill adult: recognition and prevention strategies." Crit Care Med 38(6 Suppl) (2010): S169-74. [PMID: 20502171]
4	Dubrovskaya Y, Prasad N, Lee Y, Esaian D, Figueroa DA, Tam VH "Risk factors for nephrotoxicity onset associated with polymyxin B therapy." J Antimicrob Chemother 70 (2015): 1903-7. [PMID: 25652747]
5	Kellum JA, Leblanc M, Venkataraman R "Acute renal failure." BMJ Clin Evid 9 (2008): 2001. [PMID: 19445797]
6	Marcos LA, Camins BC, Ritchie DJ, Casabar E, Warren DK "Acute renal insufficiency during telavancin therapy in clinical practice." J Antimicrob Chemother 67 (2012): 723-6. [PMID: 22174040]
7	van den Berk G, Tonino S, de Fijter C, Smit W, Schultz MJ "Bench-to-bedside review: Preventative measures for contrast-induced nephropathy in critically ill patients." Crit Care 9 (2005): 361-70. [PMID: 16137385]
8	Product Information. Osmovist 240 (iotrolan). Berlex Canada Inc, Lachine, QC.
9	Product Information. Proleukin (aldesleukin). Chiron Therapeutics, Emeryville, CA.
10	Product Information. Isovue-M-200 (iopamidol). Bracco Diagnostics Inc, Princeton, NJ.
11	Product Information. Amipaque (metrizamide) Nycomed Inc, Princeton, NJ.
12	Hindmarsh T, Grepe A, Widen L "Metrizamide-phenothiazine interaction: report of a case with seizures following myelography." Acta Radiol Diagn (Stockh) 16 (1975): 129-35. [PMID: 810000]
13	Product Information. Omnipaque 180 (iohexol). Amersham Health, Princeton, NJ.
14	Product Information. Vistide (cidofovir). Gilead Sciences, Foster City, CA.
15	Assan R, Heuclin C, Ganeval D, Bismuth C, George J, Girard JR "Metformin-induced lactic acidosis in the presence of acute renal failure." Diabetologia 13 (1977): 211-7. [PMID: 406158]
16	Gross JL, Friedman R, Silveiro SP "Preventing nephropathy induced by contrast medium." N Engl J Med 354 (2006): 1853-5 author reply 1853-5. [PMID: 16641408]
17	Product Information. Glucophage (metformin). Bristol-Myers Squibb, Princeton, NJ.
18	Product Information. Ultravist (iopromide). Berlex, Richmond, CA.
19	Stacul F, Adam A, Becker CR, et al. "Strategies to reduce the risk of contrast-induced nephropathy." Am J Cardiol 98(6S1) (2006): 59-77. [PMID: 16949381]
20	Briguori C, Marenzi G "Contrast-induced nephropathy: Pharmacological prophylaxis." Kidney Int 69(S100) (2006): S30-S38
21	Barrett BJ, Parfrey PS "Clinical practice. Preventing nephropathy induced by contrast medium." N Engl J Med 354 (2006): 379-86
22	Venkataraman R "Can we prevent acute kidney injury?" Crit Care Med 36(4 Suppl) (2008): S166-71
23	Goernig M, Kirmeier T, Krack A, Hartog CS, Figulla HR, Leder U "Iohexol contrast medium induces QT prolongation in amiodarone patients." Br J Clin Pharmacol 58 (2004): 96-98. [PMID: 15206999]
24	Cerner Multum, Inc. "Australian Product Information.".
25	Product Information. Sodium Iodide I-123 (sodium iodide I-123). GE Healthcare, Princeton, NJ.
26	Product Information. Visipaque (iodixanol). Nycomed Inc, Princeton, NJ.
27	Product Information. Omniscan (gadodiamide). Novation, Irving, TX.
28	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
29	European Medicines Agency "Summary on compassionate use. Remdesivir Gilead.".
30	Gilead Sciences, Inc "About Remdesivir.".
31	US Food and Drug Administration "Fact sheet for health care providers emergency use authorization (EUA) of remdesivir (GS-5734TM)".

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