Drug General Information (ID: DDIS74NGRX)
Drug Name			Methylprednisolone		Drug Info		Iohexol		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antineoplastics				Non-Ionic Iodinated Contrast Media
Structure

Mechanism of Methylprednisolone-Iohexol Interaction (Severity Level: Major)
Increased risk of other adverse reactions (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Methylprednisolone				Iohexol
Mechanism		Intrathecal route combined with iodinated contrast agent increases the incidence of radiation arachnoiditis				Iodinated contrast agent
Key Mechanism Factor 1
		Factor Name		Adverse reactions
		Factor Description		An adverse reaction is an unexpected negative reaction to a medication or treatment that happens even when it's used correctly.
Mechanism Description		Increased risk of adverse reactions by the combination of Iohexol and Methylprednisolone

Recommended Action
Management		Intrathecal coadministration of corticosteroids with iodinated contrast media is considered contraindicated.

References
1	Product Information. Isovue-M-200 (iopamidol). Bracco Diagnostics Inc, Princeton, NJ.
2	Product Information. Amipaque (metrizamide) Nycomed Inc, Princeton, NJ.
3	Product Information. Osmovist 240 (iotrolan). Berlex Canada Inc, Lachine, QC.