Drug General Information (ID: DDI9YOC0XG)
Drug Name			Muromonab		Drug Info		Iohexol		Drug Info
Drug Type		Monoclonal antibody				Small molecule
Therapeutic Class		Immunomodulatory Agents				Non-Ionic Iodinated Contrast Media

Mechanism of Muromonab-Iohexol Interaction (Severity Level: Major)
Increased risk of lowers seizure threshold Click to Show/Hide Mechanism Graph
Drug Name		Muromonab				Iohexol
Mechanism		Lower seizure threshold				Lower seizure threshold
Key Mechanism Factor 1
		Factor Name		Lowers seizure threshold
		Factor Description		The combination of medications that lower the seizure threshold is a factor that makes people with epilepsy more likely to have seizures. A seizure is a sudden, uncontrolled electrical disturbance in the brain that can cause changes in your behavior, movements or sensations, and level of consciousness.
Mechanism Description		Increased risk of lowers seizure threshold by the combination of Muromonab and Iohexol

Recommended Action
Management		Drugs that can lower the seizure threshold should preferably be withheld for at least 48 hours prior to and 24 hours following intrathecal administration of iodinated contrast media, provided that temporary interruption of therapy does not pose an undue risk to the patient. Otherwise, close monitoring is advised during and after contrast administration.

References
1	Product Information. Amipaque (metrizamide) Nycomed Inc, Princeton, NJ.
2	Product Information. Omnipaque 180 (iohexol). Amersham Health, Princeton, NJ.
3	Hindmarsh T, Grepe A, Widen L "Metrizamide-phenothiazine interaction: report of a case with seizures following myelography." Acta Radiol Diagn (Stockh) 16 (1975): 129-35. [PMID: 810000]