Details of Drug

Drug General Information (ID: D0581)
Drug Name	Epinephrine
Drug Type	Small molecule
Drug Synonymous	ADROP; Adnephrine; Adrenal; Adrenalin; Adrenalina; Adrenaline; Adrenalinum; Adrenamine; Adrenan; Adrenapax; Adrenasol; Adrenatrate; Adrenine; Adrenodis; Adrenohorma; Adrenosan; Adrenutol; Adrin; Adrine; Antiasthmatique; Asthmanefrin; Astmahalin; Astminhal; Balmadren; Bernarenin; Biorenine; Bosmin; Brevirenin; Bronkaid; Chelafrin; Corisol; Drenamist; Dylephrin; Epifrin; Epiglaufrin; Epinefrin; Epinefrina; Epinephran; Epinephrin; Epinephrinum; Epipen; Epirenamine; Epirenan; Epirenin; Epitrate; Eppy; Esphygmogenina; Exadrin; Glaucon; Glaucosan; Glauposine; Glycirenan; Haemostasin; Haemostatin; Hektalin; Hemisine; Hemostasin; Hemostatin; Hypernephrin; Hyporenin; IOP; Intranefrin; Iontocaine; Isoptoepinal; Kidoline; Levoadrenaline; Levoepinephrine; Levorenen; Levorenin; Levorenine; Lyophrin; Metanephrin; Methylaminoethanolcatechol; Methylarterenol; Micronefrin; Micronephrine; Mucidrina; Myosthenine; Mytrate; Nephridine; Nieraline; Paranephrin; Primatene; Racepinephrine; Renagladin; Renaglandin; Renaglandulin; Renaleptine; Renalina; Renoform; Renostypricin; Renostypticin; Renostyptin; Scurenaline; Septocaine; Simplene; Sindrenina; Soladren; Sphygmogenin; Stryptirenal; Styptirenal; Supracapsulin; Supradin; Supranefran; Supranephrane; Supranephrine; Supranol; Suprarenaline; Suprarenin; Suprel; Surenine; Surrenine; Susphrine; Takamina; Takamine; Tokamina; Tonogen; Twinject; Vaponefrin; Vasoconstrictine; Vasoconstrictor; Vasodrine; Vasoton; Vasotonin; ADR ADRENALINE; Adrenalin in Oil; Adrenalina [DCIT]; Asmatane Mist; Asthma meter mist; Asthmahaler Mist; Bronkaid Mist; Bronkaid Suspension Mist; Bupivacaine Hcl and Epinephrine; Citanest Forte; EPI E Z PEN JR; EPIPEN E Z PEN; EPIPEN JR; Epi EZ Pen Jr; Epinefrin [Czech]; Epinephrine hydrochloride; Epipen EZ Pen; Primatene Mist; Racemic Epinephrine; Sympathin I; Adrenalin (TN); Adrenalin-Medihaler; Adrenaline (JP15); Adrenaline/Epinephrine; Ana-Guard; Asthma-nefrin; D-Adrenaline; D-Epifrin; D-Epinephrine; Dyspne-Inhal; Epinefrina [INN-Spanish]; Epinephrine (USP); Epinephrinum [INN-Latin]; Epipen (TN); Epipen Auto-Injector; Epipen Jr.; L-Adrenalin; L-Adrenaline; L-Adrenaline Base; L-Epinehphrine; L-Epinephine; L-Epirenamine; L-Methylaminoethanolcatechol; L-epinephrine; Levo-Methylaminoethanolcatechol; Medihaler-Epi; R-Adrenaline; Sus-Phrine; Twinject 0.15; Twinject 0.3; Twinject 0.30; Epinephrine (USP/INN); Epinephrine [USAN:INN:JAN]; Epipen Jr. Auto-Injector; L-Epinephrine (synthetic); SUS-PHRINE SULFITE-FREE; R-(-)-Epinephrine; L-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol; (-)-(R)-Epinephrine; (-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol; (-)-Adrenalin; (-)-Adrenaline; (-)-R-Epinephrine; (R)-(-)-Adnephrine; (R)-(-)-Adrenaline; (R)-(-)-Epinephrine; (R)-(-)-Epirenamine; (R)-4-[1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol; (R)-Adrenaline; (R)-Epinephrine; 1-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol; 1-Adrenalin; 1-Epinephrine; 4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol; 4-(1-hydroxy-2-methylamino-ethyl)benzene-1,2-diol; 4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol; 4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol Click to Show/Hide
Disease Class	4A80-4A8Z: Allergic/hypersensitivity disorder
Therapeutic Class	Vasoconstrictor Agents
Structure
Structure	3D Structure		2D Structure
Formula	C9H13NO3
InChI	1S/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3/t9-/m0/s1
InChIKey	UCTWMZQNUQWSLP-VIFPVBQESA-N
Canonical SMILES	CNCC(C1=CC(=C(C=C1)O)O)O
External Link
	Pubchem ID	5816
	CAS Number	51-43-4
	CHEBI ID	28918
	TTD ID	D04PHC
	VARIDT ID	DR00076

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM009 Altered absorption (Unspecific) BM018 Non-CYP450 enzyme inhibition BM041 Additive hypertensive effects BM042 Additive hypotensive effects BM061 Increased risk of hyperpyrexia BM078 Increased risk of rapid heart rate BM081 Increased risk of ventricular arrhythmias BM083 Potentiated the pharmacological effects (Unspecific) BM086 Antagonize the effect of antidiabetic agents BM089 Antagonize the effect of antihypertensive agents BM107 Attenuated pharmacological effects (Unspecific) BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Epinephrine
Affected gastrointestinal absorption
	Altered absorption (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0814		Insulin human (inhalation, rapid acting)	C257H383N65O77S6	118984375	Moderate		Inter Info	[82], [83], [84]
Affected intra/extra-hepatic metabolism
	Non-CYP450 enzyme inhibition					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0575		Entacapone	C14H15N3O5	5281081	Moderate		Inter Info	[46], [47], [48], [49]
D1182		Opicapone	C15H10Cl2N4O6	135565903	Moderate		Inter Info	[46], [47], [48], [49]
D1604		Tolcapone	C14H11NO5	4659569	Moderate		Inter Info	[46], [47], [48], [49]
Pharmacodynamic additive effects
	Additive hypertensive effects					Drug Num: 64
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0068		Amitriptyline	C20H23N	2160	Major		Inter Info	[1], [2], [3]
D0072		Amoxapine	C17H16ClN3O	2170	Major		Inter Info	[1], [2], [3]
D0494		Dihydroergotamine	C33H37N5O5	10531	Major		Inter Info	[7], [8], [9], [10]
D0361		Clomipramine	C19H23ClN2	2801	Major		Inter Info	[1], [2], [3]
D0377		Cocaine (nasal)	C17H21NO4	446220	Major		Inter Info	[14], [15], [16]
D0378		Cocaine (topical)	C17H21NO4	446220	Major		Inter Info	[14], [15], [16]
D0446		Desipramine	C18H22N2	2995	Major		Inter Info	[1], [2], [3]
D0525		Doxepin	C19H21NO	667477	Major		Inter Info	[1], [2], [3]
D0592		Ergometrine	C19H23N3O2	443884	Major		Inter Info	[7], [10], [17]
D0593		Ergotamine	C33H35N5O5	8223	Major		Inter Info	[7], [8], [9], [18], [10], [17]
D1647		Trimipramine	C20H26N2	5584	Major		Inter Info	[1], [2], [3]
D0795		Imipramine	C19H24N2	3696	Major		Inter Info	[1], [2], [3]
D1037		Methylergometrine	C20H25N3O2	8226	Major		Inter Info	[7], [10], [17]
D1043		Methysergide	C21H27N3O2	9681	Major		Inter Info	[7], [10], [17]
D1158		Nortriptyline	C19H21N	4543	Major		Inter Info	[1], [2], [3]
D1361		Protriptyline	C19H21N	4976	Major		Inter Info	[1], [2], [3]
D0074		Amphetamine	C9H13N	3007	Moderate		Inter Info	[24], [25], [26]
D0119		Atomoxetine	C17H21NO	54841	Moderate		Inter Info	[24], [25], [26]
D0449		Desmopressin	C46H64N14O12S2	5311065	Moderate		Inter Info	[32], [33], [34]
D0523		Doxapram	C24H30N2O2	3156	Moderate		Inter Info	[24], [25], [26]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[40], [41], [42], [43], [44], [45]
D0103		Arformoterol	C19H24N2O4	3083544	Moderate		Inter Info	[50], [51], [52]
D0451		Desvenlafaxine	C16H25NO2	125017	Moderate		Inter Info	[40], [41], [42], [43], [44], [45]
D0460		Dexmethylphenidate	C14H19NO2	154101	Moderate		Inter Info	[24], [25], [26]
D0465		Dextroamphetamine	C9H13N	5826	Moderate		Inter Info	[24], [25], [26]
D0486		Diethylpropion	C13H19NO	7029	Moderate		Inter Info	[24], [25], [26]
D0538		Droxidopa	C9H11NO5	92974	Moderate		Inter Info	[55]
D0691		Formoterol	C19H24N2O4	3410	Moderate		Inter Info	[50], [51], [52]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[50], [51], [52]
D0853		Isocarboxazid	C12H13N3O2	3759	Moderate		Inter Info	[58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D0920		Levomilnacipran	C15H22N2O	6917779	Moderate		Inter Info	[40], [41], [42], [43], [44], [45]
D0924		Levosalbutamol	C13H21NO3	123600	Moderate		Inter Info	[50], [51], [52]
D0937		Lisdexamfetamine	C15H25N3O	11597698	Moderate		Inter Info	[24], [25], [26]
D1012		Metamfetamine	C10H15N	10836	Moderate		Inter Info	[24], [25], [26]
D1036		Methylene blue	C16H18ClN3S	6099	Moderate		Inter Info	[58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D1066		Milnacipran	C15H22N2O	65833	Moderate		Inter Info	[72], [74], [75], [45], [76]
D1171		Olodaterol	C21H26N2O5	11504295	Moderate		Inter Info	[50], [51], [52]
D1185		Orciprenaline	C11H17NO3	4086	Moderate		Inter Info	[50], [51], [52]
D1211		Ozanimod	C23H24N4O3	52938427	Moderate		Inter Info	[58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D1262		Phendimetrazine	C12H17NO	30487	Moderate		Inter Info	[24], [25], [26]
D1263		Phenelzine	C8H12N2	3675	Moderate		Inter Info	[58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D1298		Pirbuterol	C12H20N2O3	4845	Moderate		Inter Info	[50], [51], [52]
D1345		Procarbazine	C12H19N3O	4915	Moderate		Inter Info	[58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D1374		Racepinephrine	C9H13NO3	838	Moderate		Inter Info	[50], [51], [52]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D1414		Ritodrine	C17H21NO3	33572	Moderate		Inter Info	[50], [51], [52]
D1438		Salbutamol	C13H21NO3	2083	Moderate		Inter Info	[50], [51], [52]
D1440		Salmeterol	C25H37NO4	5152	Moderate		Inter Info	[50], [51], [52]
D1455		Selegiline	C13H17N	26757	Moderate		Inter Info	[58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[77]
D1492		Solriamfetol	C10H14N2O2	10130337	Moderate		Inter Info	[78]
D1535		Tapentadol	C14H23NO	9838022	Moderate		Inter Info	[40], [41], [42], [43], [44], [45]
D1554		Terbutaline	C12H19NO3	5403	Moderate		Inter Info	[50], [51], [52]
D1620		Tranylcypromine	C9H11N	19493	Moderate		Inter Info	[58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69], [70], [71]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Moderate		Inter Info	[50], [51], [52]
D0854		Isoetharine	C13H21NO3	3762	Moderate		Inter Info	[50], [51], [52]
D0981		Mazindol	C16H13ClN2O	4020	Moderate		Inter Info	[24], [25], [26]
D1039		Methylphenidate	C14H19NO2	4158	Moderate		Inter Info	[24], [25], [26]
D1061		Midodrine	C12H18N2O4	4195	Moderate		Inter Info	[14], [17]
D1210		Oxytocin	C43H66N12O12S2	439302	Moderate		Inter Info	[14], [85], [86]
D1270		Phentermine	C10H15N	4771	Moderate		Inter Info	[24], [25], [26]
D1281		Phenylpropanolamine	C9H13NO	26934	Moderate		Inter Info	[24], [25], [26]
D1683		Vasopressin	C46H65N15O12S2	644077	Moderate		Inter Info	[32], [33], [34]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[40], [41], [42], [43], [44], [45]
	Additive hypotensive effects					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0586		Epoprostenol	C20H32O5	5282411	Moderate		Inter Info	[38], [56], [57]
D0792		Iloprost	C22H32O4	5311181	Moderate		Inter Info	[38], [56], [57]
D1457		Selexipag	C26H32N4O4S	9913767	Moderate		Inter Info	[38], [56], [57]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[38], [56], [57]
	Increased risk of hyperpyrexia					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0933		Linezolid	C16H20FN3O4	441401	Major		Inter Info	[19], [20]
	Increased risk of ventricular arrhythmias					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0491		Digoxin	C41H64O14	2724385	Moderate		Inter Info	[35], [36], [37]
D0490		Digitoxin	C41H64O13	441207	Moderate		Inter Info	[35], [36], [37]
	Potentiated the pharmacological effects (Unspecific)					Drug Num: 21
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0265		Carteolol	C16H24N2O3	2583	Major		Inter Info	[4], [5], [6]
D0266		Carteolol (ophthalmic)	C16H24N2O3	2583	Major		Inter Info	[4], [5], [6]
D0267		Carvedilol	C24H26N2O4	2585	Major		Inter Info	[4], [5], [6]
D0915		Levobunolol (ophthalmic)	C17H25NO3	39468	Major		Inter Info	[4], [5], [6]
D1045		Metipranolol (ophthalmic)	C17H27NO4	31477	Major		Inter Info	[4], [5], [6]
D1098		Nadolol	C17H27NO4	39147	Major		Inter Info	[4], [5], [6]
D1244		Penbutolol	C18H29NO2	37464	Major		Inter Info	[4], [5], [6]
D1293		Pindolol	C14H20N2O2	4828	Major		Inter Info	[4], [5], [6]
D0884		Labetalol	C19H24N2O3	3869	Major		Inter Info	[4], [5], [6]
D1357		Propranolol	C16H21NO2	4946	Major		Inter Info	[4], [5], [6]
D1498		Sotalol	C12H20N2O3S	5253	Major		Inter Info	[4], [5], [6]
D1585		Timolol	C13H24N4O3S	33624	Major		Inter Info	[4], [5], [6]
D1586		Timolol (ophthalmic)	C13H24N4O3S	33624	Major		Inter Info	[4], [5], [6]
D0444		Deserpidine	C32H38N2O8	8550	Moderate		Inter Info	[38], [53], [54]
D0744		Guanethidine	C10H22N4	3518	Moderate		Inter Info	[38], [53], [54]
D0918		Levodopa	C9H11NO4	6047	Moderate		Inter Info	[72], [14], [73]
D1577		Thyroid, porcine	NA	NA	Moderate		Inter Info	[79], [80], [81]
D0743		Guanadrel	C10H19N3O2	38521	Moderate		Inter Info	[38], [53], [54]
D0925		Levothyroxine	C15H11I4NO4	5819	Moderate		Inter Info	[79], [80], [81]
D0934		Liothyronine	C15H12I3NO4	5920	Moderate		Inter Info	[79], [80], [81]
D1393		Reserpine	C33H40N2O9	5770	Moderate		Inter Info	[38], [53], [54]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0570		Enflurane	C3H2ClF5O	3226	Major		Inter Info	[11], [12], [13]
D0445		Desflurane	C3H2F6O	42113	Major		Inter Info	[11], [12], [13]
D0751		Halothane	C2HBrClF3	3562	Major		Inter Info	[11], [12], [13]
D0855		Isoflurane	C3H2ClF5O	3763	Major		Inter Info	[11], [12], [13]
D1030		Methoxyflurane	C3H4Cl2F2O	4116	Major		Inter Info	[11], [12], [13]
D1463		Sevoflurane	C4H3F7O	5206	Major		Inter Info	[11], [12], [13]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antidiabetic agents					Drug Num: 36
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0009		Acarbose	C25H43NO18	41774	Moderate		Inter Info	[21], [22], [23]
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[21], [22], [23]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[21], [22], [23]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[21], [22], [23]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[21], [22], [23]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[21], [22], [23]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[21], [22], [23]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[21], [22], [23]
D0807		Insulin aspart (aspart protamine)	C256H381N65O79S6	118984445	Moderate		Inter Info	[21], [22], [23]
D0808		Insulin aspart (aspart)	C256H381N65O79S6	118984445	Moderate		Inter Info	[21], [22], [23]
D0809		Insulin degludec	C274H411N65O81S6	118984462	Moderate		Inter Info	[21], [22], [23]
D0810		Insulin detemir	C267H402N64O76S6	16137271	Moderate		Inter Info	[21], [22], [23]
D0812		Insulin glulisine	C258H384N64O78S6	16136701	Moderate		Inter Info	[21], [22], [23]
D0930		Linagliptin	C25H28N8O2	10096344	Moderate		Inter Info	[21], [22], [23]
D0936		Liraglutide	C172H265N43O51	16134956	Moderate		Inter Info	[21], [22], [23]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[21], [22], [23]
D1294		Pioglitazone	C19H20N2O3S	4829	Moderate		Inter Info	[21], [22], [23]
D1326		Pramlintide	C171H267N51O53S2	70691388	Moderate		Inter Info	[21], [22], [23]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[21], [22], [23]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[21], [22], [23]
D1477		Sitagliptin	C16H15F6N5O	4369359	Moderate		Inter Info	[21], [22], [23]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[21], [22], [23]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[21], [22], [23]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[21], [22], [23]
D0811		Insulin glargine	C267H404N72O78S6	118984454	Moderate		Inter Info	[21], [22], [23]
D0813		Insulin human	C257H383N65O77S6	118984375	Moderate		Inter Info	[21], [22], [23]
D0815		Insulin human (isophane)	C257H383N65O77S6	118984375	Moderate		Inter Info	[21], [22], [23]
D0816		Insulin human (regular)	C257H383N65O77S6	118984375	Moderate		Inter Info	[21], [22], [23]
D0817		Insulin human (zinc extended)	C257H383N65O77S6	118984375	Moderate		Inter Info	[21], [22], [23]
D0818		Insulin human (zinc)	C257H383N65O77S6	118984375	Moderate		Inter Info	[21], [22], [23]
D0819		Insulin lispro	C257H389N65O77S6	16132438	Moderate		Inter Info	[21], [22], [23]
D0820		Insulin lispro (protamine)	C257H389N65O77S6	16132438	Moderate		Inter Info	[21], [22], [23]
D1015		Metformin	C4H11N5	4091	Moderate		Inter Info	[21], [22], [23]
D1064		Miglitol	C8H17NO5	441314	Moderate		Inter Info	[21], [22], [23]
D1429		Rosiglitazone	C18H19N3O3S	77999	Moderate		Inter Info	[21], [22], [23]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[21], [22], [23]
	Antagonize the effect of antihypertensive agents					Drug Num: 13
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0117		Atenolol	C14H22N2O3	2249	Moderate		Inter Info	[27], [6], [28]
D0174		Betaxolol (ophthalmic)	C18H29NO3	2369	Moderate		Inter Info	[27], [6], [28]
D0188		Bisoprolol	C18H31NO4	2405	Moderate		Inter Info	[27], [6], [28]
D0535		Droperidol	C22H22FN3O2	3168	Moderate		Inter Info	[38], [39]
D0010		Acebutolol	C18H28N2O4	1978	Moderate		Inter Info	[27], [6], [28]
D1779		Dulaglutide	NA	NA	Moderate		Inter Info	[21], [22], [23]
D1782		Ertugliflozin	C22H25ClO7	44814423	Moderate		Inter Info	[21], [22], [23]
D1784		Exenatide	C184H282N50O60S	45588096	Moderate		Inter Info	[21], [22], [23]
D0914		Levobetaxolol (ophthalmic)	C18H29NO3	60657	Moderate		Inter Info	[27], [6], [28]
D1114		Nebivolol	C22H25F2NO4	71301	Moderate		Inter Info	[27], [6], [28]
D1887		Semaglutide	C187H291N45O59	56843331	Moderate		Inter Info	[21], [22], [23]
D0602		Esmolol	C16H25NO4	59768	Moderate		Inter Info	[27], [6], [28]
D1049		Metoprolol	C15H25NO3	4171	Moderate		Inter Info	[27], [6], [28]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 32
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[29], [30], [31]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[29], [30], [31]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[29], [30], [31]
D0067		Amisulpride	C17H27N3O4S	2159	Moderate		Inter Info	[29], [30], [31]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[29], [30], [31]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[29], [30], [31]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Moderate		Inter Info	[29], [30], [31]
D0791		Iloperidone	C24H27FN2O4	71360	Moderate		Inter Info	[29], [30], [31]
D0959		Lumateperone	C24H28FN3O	21302490	Moderate		Inter Info	[29], [30], [31]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[29], [30], [31]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[29], [30], [31]
D1019		Methdilazine	C18H20N2S	14677	Moderate		Inter Info	[29], [30], [31]
D1026		Methotrimeprazine	C19H24N2OS	72287	Moderate		Inter Info	[29], [30], [31]
D1084		Molindone	C16H24N2O2	23897	Moderate		Inter Info	[29], [30], [31]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[29], [30], [31]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[29], [30], [31]
D1292		Pimozide	C28H29F2N3O	16362	Moderate		Inter Info	[29], [30], [31]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[29], [30], [31]
D1355		Propiomazine	C20H24N2OS	4940	Moderate		Inter Info	[29], [30], [31]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[29], [30], [31]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[29], [30], [31]
D1576		Thiothixene	C23H29N3O2S2	941651	Moderate		Inter Info	[29], [30], [31]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[29], [30], [31]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[29], [30], [31]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[29], [30], [31]
D0957		Loxapine	C18H18ClN3O	3964	Moderate		Inter Info	[29], [30], [31]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[29], [30], [31]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[29], [30], [31]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[29], [30], [31]
D1572		Thiethylperazine	C22H29N3S2	5440	Moderate		Inter Info	[29], [30], [31]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[29], [30], [31]
D1726		Ziprasidone	C21H21ClN4OS	60854	Moderate		Inter Info	[29], [30], [31]

References
1	Ghose K "Sympathomimetic amines and tricyclic antidepressant drugs." Neuropharmacology 19 (1980): 1251-4.[PMID: 7442960]
2	Borg KO, Johnsson G, Jordo L, Lundborg P, Ronn O, Welin-Fogelberg I "Interaction studies between three antidepressant drugs (zimelidine, imipramine and chlorimipramine) and noradrenaline in healthy volunteers and some pharmacokinetics of the drugs studied." Acta Pharmacol Toxicol (Copenh) 45 (1979): 198-205.[PMID: 506742]
3	Fritz H, Hagstam KE, Lindqvist B "Local skin necrosis after intravenous infusion of norepinephrine, and the concept of endotoxinaemia. A clinical study on 10 cases." Acta Med Scand 178 (1965): 403-16.[PMID: 5838313]
4	Spencer PS, Klein LE "Interaction of epinephrine and propranolol." J Am Acad Dermatol 14 (1986): 1093-4.[PMID: 3722489]
5	O'Grady J, Oh V, Turner P "Effects of propranolol and oxprenolol on the vasoconstrictor response to noradrenaline in the superficial hand vein in man." Eur J Clin Pharmacol 14 (1978): 83-5.[PMID: 720378]
6	Richards DA, Prichard BN, Hernandez R "Circulatory effects of noradrenaline and adrenaline before and after labetalol." Br J Clin Pharmacol 7 (1979): 371-8.[PMID: 444356]
7	Barthel W, Glusa E, Koth W "Interactions of dihydroergotamine with etilefrine in human leg veins in vitro and in situ." Int J Clin Pharmacol Ther Toxicol 25 (1987): 63-9. [PMID: 2881898]
8	Buchanan N, Cane RD, Miller M "Symmetrical gangrene of the extremities associated with the use of dopamine subsequent to ergometrine administration." Intensive Care Med 3 (1977): 55-6. [PMID: 561121]
9	Chuang SS "Finger ischemia secondary to the synergistic agonist effect of norepinephrine and ergonovine and in a burn patient." Burns 29 (2003): 92-4. [PMID: 12543053]
10	Product Information. D.H.E. 45 (dihydroergotamine). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
11	Product Information. Ultane (sevoflurane). Abbott Pharmaceutical, Abbott Park, IL.
12	Konchigeri HN, Shaker MH, Winnie AP "Effect of epinephrine during enflurane anesthesia." Anesth Analg 53 (1974): 894-7.[PMID: 4473933]
13	Karl HW, Swedlow DB, Lee KW, Downes JJ "Epinephrine-halothane interactions in children." Anesthesiology 58 (1983): 142-5.[PMID: 6337528]
14	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
15	Thevasagyam M, Jindal M, Allsop P, Oates J "Does epinephrine infiltration in septoplasty make any difference?" Eur Arch Otorhinolaryngol 264 (2007): 1175-8.[PMID: 17530270]
16	Product Information. Cocaine Hydrochloride (cocaine topical). Mallinckrodt Medical Inc, St. Louis, MO.
17	Product Information. ProAmatine (midodrine). Roberts Pharmaceutical Corporation, Eatontown, NJ.
18	Product Information. Bellergal-S (ergotamine). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
19	Hendershot PE, Antal EJ, Welshman IR, Batts DH, Hopkins NK "Linezolid: pharmacokinetic and pharmacodynamic evaluation of coadministration with pseudoephedrine HCl, phenylpropanolamine HCl, and dextromethorpan HBr." J Clin Pharmacol 41 (2001): 563-72. [PMID: 11361053]
20	Product Information. Zyvox (linezolid) Pharmacia and Upjohn, Kalamazoo, MI.
21	Jori A, Carrara MC "On the mechanism of the hyperglycaemic effect of chlorpromazine." J Pharm Pharmacol 18 (1966): 623-4. [PMID: 4381950]
22	Product Information. Dymelor (acetohexamide) Lilly, Eli and Company, Indianapolis, IN.
23	Product Information. Thorazine (chlorpromazine). SmithKline Beecham, Philadelphia, PA.
24	Product Information. Focalin (dexmethylphenidate). Mikart Inc, Atlanta, GA.
25	Product Information. Strattera (atomoxetine). Lilly, Eli and Company, Indianapolis, IN.
26	Cavanaugh JH, Griffith JD, Oates JA "Effect of amphetamine on the pressor response to tyramine: formation of p-hydroxynorephedrine from amphetamine in man." Clin Pharmacol Ther 11 (1970): 656
27	Product Information. Dobutrex (dobutamine). Lilly, Eli and Company, Indianapolis, IN.
28	Product Information. Intropin (dopamine). DuPont Pharmaceuticals, Wilmington, DE.
29	Product Information. Clozaril (clozapine). Novartis Pharmaceuticals, East Hanover, NJ.
30	Product Information. Seroquel (quetiapine). Zeneca Pharmaceuticals, Wilmington, DE.
31	Product Information. Loxitane C Oral Concentrate (loxapine) Watson Laboratories Inc, Corona, CA.
32	Product Information. DDAVP (desmopressin). Rhone-Poulenc Rorer, Collegeville, PA.
33	Product Information. Vasostrict (vasopressin). Par Pharmaceutical Inc, Chestnut Ridge, NY.
34	Russell JA, Walley KR, Singer J, et al. "Vasopressin versus norepinephrine infusion in patients with septic shock." N Engl J Med 358 (2008): 877-87
35	Product Information. Lanoxin (digoxin). Glaxo Wellcome, Research Triangle Park, NC.
36	Product Information. Claritin-D (loratadine-pseudoephedrine). Schering-Plough, Liberty Corner, NJ.
37	Product Information. Epinephrine Hydrochloride Injection (epinephrine). Abbott Pharmaceutical, Abbott Park, IL.
38	Hardman JG, Gilman AG, Limbird LE eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 9th ed." New York, NY: McGraw-Hill (1995):.
39	Product Information. Inapsine (droperidol). Janssen Pharmaceutica, Titusville, NJ.
40	Product Information. Cymbalta (duloxetine). Lilly, Eli and Company, Indianapolis, IN.
41	Product Information. Effexor (venlafaxine). Wyeth-Ayerst Laboratories, Philadelphia, PA.
42	Product Information. Fetzima (levomilnacipran). Forest Pharmaceuticals, St. Louis, MO.
43	Product Information. Nucynta (tapentadol). PriCara Pharmaceuticals, Raritan, NJ.
44	Product Information. Pristiq (desvenlafaxine). Wyeth Laboratories, Philadelphia, PA.
45	Product Information. Savella (milnacipran). Forest Pharmaceuticals, St. Louis, MO.
46	Illi A, Sundberg S, Ojala-Karlsson P, Korhonen P, Scheinin M, Gordin A "The effect of entacapone on the disposition and hemodynamic effects of intravenous isoproterenol and epinephrine." Clin Pharmacol Ther 58 (1995): 221-7. [PMID: 7648772]
47	Product Information. Comtan (entacapone) Novartis Pharmaceuticals, East Hanover, NJ.
48	Product Information. Ongentys (opicapone). Neurocrine Biosciences, Inc., San Diego, CA.
49	Product Information. Tasmar (tolcapone). Valeant Pharmaceuticals, Costa Mesa, CA.
50	Lowe MD, Rowland E, Brown MJ, Grace AA "Beta(2) adrenergic receptors mediate important electrophysiological effects in human ventricular myocardium." Heart 86 (2001): 45-51. [PMID: 11410561]
51	Product Information. Breo Ellipta (fluticasone-vilanterol). GlaxoSmithKline, Research Triangle Park, NC.
52	Product Information. Brovana (arformoterol). Sepracor Inc, Marlborough, MA.
53	Muelheims GH, Entrup RW, Paiewonsky D, Mierzwiak DS "Increased sensitivity of the heart to catecholamine-induced arrhythmias following guanethidine." Clin Pharmacol Ther 6 (1965): 757-62
54	Spiers AS, Calne DB "Action of dopamine on the human iris." Br Med J 4 (1969): 333-5
55	Product Information. Northera (droxidopa). Chelsea Therapeutics Inc, Charlotte, NC.
56	Product Information. Flolan (epoprostenol). Glaxo Wellcome, Research Triangle Park, NC.
57	Product Information. Remodulin (treprostinil). United Therapeutics Corp, Silver Spring, MD.
58	Ban TA "Drug interactions with psychoactive drugs." Dis Nerv Syst 36 (1975): 164-6. [PMID: 1116424]
59	Boakes AJ, Laurence DR, Teoh PC, Barar FS, Benedikter LT, Pritchard BN "Interactions between sympathomimetic amines and antidepressant agents in man." Br Med J 1 (1973): 311-5. [PMID: 4685619]
60	Cusson JR, Goldenberg E, Larochelle P "Effect of a novel monoamine-oxidase inhibitor, moclobemide on the sensitivity to intravenous tyramine and norepinephrine in humans." J Clin Pharmacol 31 (1991): 462-7. [PMID: 2050833]
61	Darcy PF, Griffin JP "Interactions with drugs used in the treatment of depressive illness." Adverse Drug React Toxicol Rev 14 (1995): 211-31. [PMID: 8845455]
62	De Vita VT, Hahn MA, Oliverio VT "Monoamine oxidase inhibition by a new carcinostatic agent, n-isopropyl-a-(2-methylhydrazino)-p-toluamide (MIH). (30590)." Proc Soc Exp Biol Med 120 (1965): 561-5. [PMID: 4379192]
63	Elis J, Laurence DR, Mattie H, Prichard BN "Modification by monoamine oxidase inhibitors of the effect of some sympathomimetics on blood pressure." Br Med J 2 (1967): 75-8. [PMID: 6020852]
64	Goldberg LI "Monoamine oxidase inhibitors: adverse reactions and possible mechanisms." JAMA 190 (1964): 456-62. [PMID: 14197995]
65	Goulet JP, Perusse R, Turcotte JY "Contraindications to vasoconstrictors in dentistry: Part III. Pharmacologic interactions." Oral Surg Oral Med Oral Pathol 74 (1992): 692-7. [PMID: 1359489]
66	Pettinger WA, Soyangco FG, Oates JA "Inhibition of monoamine oxidase in man by furazolidone." Clin Pharmacol Ther 9 (1968): 442-7. [PMID: 5655478]
67	Schulz R, Antonin KH, Hoffmann E, et al "Tyramine kinetics and pressor sensitivity during monoamine oxidase inhibition by selegiline." Clin Pharmacol Ther 46 (1989): 528-36. [PMID: 2510962]
68	Sjoerdsma A "Catecholamine-drug interactions in man." Pharmacol Rev 18 (1966): 673-83. [PMID: 5904180]
69	Smookler S, Barmudez AJ "Hypertensive crisis resulting from an MAO inhibitor and an over-the counter appetite suppressant." Ann Emerg Med 11 (1982): 482-4. [PMID: 7114595]
70	Thompson DS, Sweet RA, Marzula K, Peredes JC "Lack of interaction of monoamine oxidase inhibitors and epinephrine in an older patient." J Clin Psychopharmacol 17 (1997): 322-3. [PMID: 9241014]
71	Wright SP "Hazards with monoamine-oxidase inhibitors: a persistent problem." Lancet 1 (1978): 284-5. [PMID: 74715]
72	Cerner Multum, Inc. "Australian Product Information.".
73	Wohlt PD, Zheng L, Gunderson S, Balzar SA, Johnson BD, Fish JT "Recommendations for the use of medications with continuous enteral nutrition." Am J Health Syst Pharm 66 (2009): 1438-67. [PMID: 19667002]
74	Forman MB, Sutej PG, Jackson EK "Hypertension, tachycardia, and reversible cardiomyopathy temporally associated with milnacipran use." Tex Heart Inst J 38 (2011): 714-8. [PMID: 22199446]
75	Palmer RH, Periclou A, Banerjee P "Milnacipran: a selective serotonin and norepinephrine dual reuptake inhibitor for the management of fibromyalgia" Ther Adv Musculoskelet Dis 2 (2010): 201-20. [PMID: 22870448]
76	Yoshida K, Higuchi H, Takahashi H, Shimizu T "Elevation of blood pressure induced by high-dose milnacipran." Hum Psychopharmacol 17 (2002): 431. [PMID: 12457380]
77	Product Information. Meridia (sibutramine). Knoll Pharmaceutical Company, Whippany, NJ.
78	Product Information. Sunosi (solriamfetol). Jazz Pharmaceuticals, Palo Alto, CA.
79	Product Information. Armour thyroid (thyroid desiccated). Forest Pharmaceuticals, St. Louis, MO.
80	Product Information. Synthroid (levothyroxine). Abbott Pharmaceutical, Abbott Park, IL.
81	Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA."
82	Black DM, Filak AT "Hyperglycemia with non-insulin-dependent diabetes following intraarticular steroid injection." J Fam Pract 28 (1989): 462-3. [PMID: 2703816]
83	Greenstone MA, Shaw AB "Alternate day corticosteroid causes alternate day hyperglycaemia." Postgrad Med J 63 (1987): 761-4. [PMID: 3444801]
84	Product Information. EXUBERA (insulin inhalation, rapid acting). Pfizer U.S. Pharmaceuticals Group, New York, NY.
85	Mendelson J, Jones RT, Upton R, Jacob P 3rd "Methamphetamine and ethanol interactions in humans." Clin Pharmacol Ther 57 (1995): 559-68. [PMID: 7768079]
86	Product Information. Syntocinon (oxytocin). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.

Details of Drug

Details of Drug

Cite MecDDI

About MecDDI

Correspondence