Drug General Information (ID: DDI1UNWG8B)
Drug Name			Epinephrine		Drug Info		Molindone		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Vasoconstrictor Agents				Antipsychotic Agents
Structure

Mechanism of Epinephrine-Molindone Interaction (Severity Level: Moderate)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Epinephrine				Molindone
Mechanism		Sympathomimetic amine				Inhibit or reverse the pressor effect of some sympathomimetics
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Epinephrine when combined with Molindone

Recommended Action
Management		Adrenaline, dopamine, and similar vasoconstrictors should not be used to treat drug-induced hypotension and circulatory collapse in patients taking phenothiazines or other neuroleptic agents. alternative vasopressor agents such as metaraminol, noradrenaline (norepinephrine), or phenylephrine should be considered, and vital signs closely monitored.

References
1	Product Information. Clozaril (clozapine). Novartis Pharmaceuticals, East Hanover, NJ.
2	Product Information. Seroquel (quetiapine). Zeneca Pharmaceuticals, Wilmington, DE.
3	Product Information. Loxitane C Oral Concentrate (loxapine) Watson Laboratories Inc, Corona, CA.