Drug General Information (ID: DDIZCDPH7M)
Drug Name			Insulin human (inhalation, rapid acting)		Drug Info		Epinephrine		Drug Info
Drug Type		Hormones				Small molecule
Therapeutic Class		Insulin/Antidiabetic Agents				Vasoconstrictor Agents
Structure

Mechanism of Insulin human (inhalation, rapid acting)-Epinephrine Interaction (Severity Level: Moderate)
Altered absorption (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Insulin human (inhalation, rapid acting)				Epinephrine
Mechanism		Inhaled human insulin				Alter the absorption of inhaled human insulin
Key Mechanism Factor 1
		Factor Name		Pharmacokinetic
		Factor Description		Alters the absorption of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Altered absorption of Insulin human (inhalation, rapid acting) caused by Epinephrine

Recommended Action
Management		Systemic administration or systemic absorption of orally inhaled corticosteroids and sympathomimetic amines (bronchodilators) may result in diminished efficacy of insulin. These drugs may interfere with blood glucose control because they can cause hyperglycemia, glucose intolerance, new-onset diabetes mellitus, and/or exacerbation of preexisting diabetes.

References
1	Black DM, Filak AT "Hyperglycemia with non-insulin-dependent diabetes following intraarticular steroid injection." J Fam Pract 28 (1989): 462-3. [PMID: 2703816]
2	Greenstone MA, Shaw AB "Alternate day corticosteroid causes alternate day hyperglycaemia." Postgrad Med J 63 (1987): 761-4. [PMID: 3444801]
3	Product Information. EXUBERA (insulin inhalation, rapid acting). Pfizer U.S. Pharmaceuticals Group, New York, NY.