Drug General Information (ID: DDI1JSXERA)
Drug Name			Fluphenazine		Drug Info		Epinephrine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antipsychotic Agents				Vasoconstrictor Agents
Structure

Mechanism of Fluphenazine-Epinephrine Interaction (Severity Level: Moderate)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Fluphenazine				Epinephrine
Mechanism		Inhibit or reverse the pressor effect of some sympathomimetics				Sympathomimetic amine
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Fluphenazine when combined with Epinephrine

Recommended Action
Management		Adrenaline, dopamine, and similar vasoconstrictors should not be used to treat drug-induced hypotension and circulatory collapse in patients taking phenothiazines or other neuroleptic agents. alternative vasopressor agents such as metaraminol, noradrenaline (norepinephrine), or phenylephrine should be considered, and vital signs closely monitored.

References
1	Product Information. Clozaril (clozapine). Novartis Pharmaceuticals, East Hanover, NJ.
2	Product Information. Seroquel (quetiapine). Zeneca Pharmaceuticals, Wilmington, DE.
3	Product Information. Loxitane C Oral Concentrate (loxapine) Watson Laboratories Inc, Corona, CA.