Details of Drug

Drug General Information (ID: D0354)
Drug Name	Clindamycin
Drug Type	Small molecule
Drug Synonymous	Antirobe; CLDM; CLY; Chlolincocin; Chlorlincocin; Chlorodeoxylincomycin; Chlorolincomycin; Cleocin; ClindaDerm; Clindamicina; Clindamycine; Clindamycinum; Clinimycin; Dalacine; Klimicin; Sobelin; Zindaclin; Cleocin HCl; Cleocin T Gel; Cleocin T Lotion; Cleocin T Topical Solution; Clindamycine [French]; Dalacin C; Dalacin C Flavored Granules; Dalacin C Phosphate; Dalacin T Topical Solution; ResiDerm A; Klindan 300; U 21251; Cleocin (TN); Clindacin (TN); Clindamicina [INN-Spanish]; Clindamycin & Interleukin 12; Clindamycin & VRC3375; Clindamycine [INN-French]; Clindamycinum [INN-Latin]; Dalacin (TN); Evoclin (TN); U-21251; CLINDA & IL-12; Clindamycin (USAN/INN); Clindamycin [USAN:BAN:INN]; U-21,251; 7(S)-Chloro-7-deoxylincomycin; 7-CDL; 7-Chloro-7-deoxylincomycin; 7-Chlorolincomycin; 7-Deoxy-7(S)-chlorolincomycin Click to Show/Hide
Disease Class	ED80: Acne vulgaris
Therapeutic Class	Antibiotics
Structure
Structure	3D Structure		2D Structure
Formula	C18H33ClN2O5S
InChI	1S/C18H33ClN2O5S/c1-5-6-10-7-11(21(3)8-10)17(25)20-12(9(2)19)16-14(23)13(22)15(24)18(26-16)27-4/h9-16,18,22-24H,5-8H2,1-4H3,(H,20,25)/t9-,10+,11-,12+,13-,14+,15+,16+,18+/m0/s1
InChIKey	KDLRVYVGXIQJDK-AWPVFWJPSA-N
Canonical SMILES	CCCC1CC(N(C1)C)C(=O)NC(C2C(C(C(C(O2)SC)O)O)O)C(C)Cl
External Link
	Pubchem ID	446598
	CAS Number	18323-44-9
	TTD ID	D0R0ZL
	INTEDE ID	DR0340
	VARIDT ID	DR00972

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM002 Altered intestinal flora BM004 Adsorption BM013 Competitive binding of plasma proteins BM014 Interference of cell/tissue uptake BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM045 Additive neuromuscular blocking effects BM068 Increased risk of intestinal flora disorders BM072 Increased risk of nephrotoxicity BM100 Antagonize the effect of vaccine/toxoid BM104 Competitive binding of the 50S ribosomal subunit BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Clindamycin
Affected gastrointestinal absorption
	Altered intestinal flora					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1094		Mycophenolate mofetil	C23H31NO7	5281078	Moderate		Inter Info	[32], [33]
D1095		Mycophenolic acid	C17H20O6	446541	Moderate		Inter Info	[32], [33]
	Adsorption					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0125		Attapulgite	Al2H29Mg2O15Si4-	56842194	Moderate		Inter Info	[20], [21], [22], [5], [17]
D0877		Kaolin	Al2H4O9Si2	56841936	Moderate		Inter Info	[20], [21], [22], [5], [17]
Affected organization distribution
	Competitive binding of plasma proteins					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[34]
	Interference of cell/tissue uptake					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1817		Indium In-111 oxyquinoline	C27H18InN3O3	16685037	Moderate		Inter Info	[23]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 23
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[5]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[5]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[19]
D0192		Boceprevir	C27H45N5O5	10324367	Moderate		Inter Info	[5]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[5]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[5]
D0375		Cobicistat	C40H53N7O5S2	25151504	Moderate		Inter Info	[5]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[5]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[5]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[5]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[5]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[5]
D1541		Telaprevir	C36H53N7O6	3010818	Moderate		Inter Info	[5]
D1653		Troleandomycin	C41H67NO15	202225	Moderate		Inter Info	[5]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[5]
D0386		Conivaptan	C32H26N4O2	151171	Moderate		Inter Info	[5]
D0439		Delavirdine	C22H28N6O3S	5625	Moderate		Inter Info	[5]
D0799		Indinavir	C36H47N5O4	5362440	Moderate		Inter Info	[5]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Moderate		Inter Info	[5]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[5]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[5]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[5]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[5]
	CYP450 enzyme induction					Drug Num: 13
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[7], [5]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Moderate		Inter Info	[7], [5]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[7], [5]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[7], [5]
D0958		Lumacaftor	C24H18F2N2O5	16678941	Moderate		Inter Info	[7], [5], [24]
D1401		Rifapentine	C47H64N4O12	135403821	Moderate		Inter Info	[7], [5]
D1502		St. John's Wort	NA	NA	Moderate		Inter Info	[7], [5]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[7], [5]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[7], [5]
D1340		Primidone	C12H14N2O2	4909	Moderate		Inter Info	[7], [5]
D1399		Rifabutin	C46H62N4O11	135398743	Moderate		Inter Info	[7], [5]
D1400		Rifampicin	C43H58N4O12	135398735	Moderate		Inter Info	[7], [5], [24]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[5]
Pharmacodynamic additive effects
	Additive neuromuscular blocking effects					Drug Num: 11
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0343		Cisatracurium	C53H72N2O12+2	62887	Moderate		Inter Info	[8], [9], [10], [11], [12], [1], [13], [14], [15], [5], [16], [17], [18]
D0122		Atracurium	C53H72N2O12+2	47319	Moderate		Inter Info	[8], [9], [10], [11], [12], [1], [13], [14], [15], [5], [16], [17], [18]
D1047		Metocurine	C40H48N2O6+2	21233	Moderate		Inter Info	[8], [9], [10], [11], [12], [1], [13], [14], [15], [5], [16], [17], [18]
D1219		Pancuronium	C35H60N2O4+2	441289	Moderate		Inter Info	[8], [9], [10], [11], [12], [1], [13], [14], [15], [5], [16], [17], [18]
D1295		Pipecuronium	C35H62N4O4+2	50192	Moderate		Inter Info	[8], [9], [10], [11], [12], [1], [13], [14], [15], [5], [16], [17], [18]
D1384		Rapacuronium	C37H61N2O4+	5311399	Moderate		Inter Info	[8], [9], [10], [11], [12], [1], [13], [14], [15], [5], [16], [17], [18]
D1659		Tubocurarine	C37H41N2O6+	6000	Moderate		Inter Info	[8], [9], [10], [11], [12], [1], [13], [14], [15], [5], [16], [17], [18]
D1684		Vecuronium	C34H57N2O4+	39765	Moderate		Inter Info	[8], [9], [10], [11], [12], [1], [13], [14], [15], [5], [16], [17], [18]
D0522		Doxacurium	C56H78N2O16+2	60169	Moderate		Inter Info	[8], [9], [10], [11], [12], [1], [13], [14], [15], [5], [16], [17], [18]
D1420		Rocuronium	C32H53N2O4+	441290	Moderate		Inter Info	[8], [9], [10], [11], [12], [1], [13], [14], [15], [5], [16], [17], [18]
D1510		Succinylcholine	C14H30N2O4+2	5314	Moderate		Inter Info	[8], [9], [10], [11], [12], [1], [13], [14], [15], [5], [16], [17], [18]
	Increased risk of intestinal flora disorders					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0079		Ampicillin	C16H19N3O4S	6249	Minor		Inter Info	[35]
D0141		Bacampicillin	C21H27N3O7S	441397	Minor		Inter Info	[35]
	Increased risk of nephrotoxicity					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0724		Givosiran	C78H139N11O30	119058042	Moderate		Inter Info	[12], [1]
D1304		Plazomicin	C25H48N6O10	42613186	Moderate		Inter Info	[12], [1]
D0718		Gentamicin	C21H43N5O7	3467	Moderate		Inter Info	[12], [1]
Pharmacodynamic antagonistic effects
	Antagonize the effect of vaccine/toxoid					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[1], [2], [3]
D1693		Vibrio cholerae CVD 103-HgR strain live antigen (live)	NA	NA	Major		Inter Info	[4]
	Competitive binding of the 50S ribosomal subunit					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[31], [5]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0145		Balsalazide	C17H15N3O6	54585	Moderate		Inter Info	[6]
D1011		Mestranol	C21H26O2	6291	Moderate		Inter Info	[25], [26], [27]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[28], [29], [30]
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[25], [26], [27]

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	UK government "Typhoid.".
3	American Medical Association, Division of Drugs and Toxicology "Drug evaluations annual 1994." Chicago, IL: American Medical Association (1994).
4	Product Information. Vaxchora (cholera vaccine, live). PaxVax, Miami, FL.
5	Product Information. Cleocin (clindamycin). Pharmacia and Upjohn, Kalamazoo, MI.
6	Product Information. Colazal (balsalazide) Salix Pharmaceuticals, Palo Alto, CA.
7	Bernard A, Kermarrec G, Parize P, et.al "Dramatic reduction of clindamycin serum concentration in staphylococcal osteoarticular infection patients treated with the oral clindamycin-rifampicin combination." J Infect 71 (2015): 200-6. [PMID: 25936632]
8	Alahdal O, Bevan DR "Clindamycin-induced neuromuscular blockade." Can J Anaesth 42 (1995): 614-7. [PMID: 7553999]
9	Avery D, Finn R "Succinylcholine-prolonged apnea associated with clindamycin and abnormal liver function tests." Dis Nerv Syst 38 (1977): 473-5. [PMID: 862507]
10	Boolj LH, Miller RD, Crul JF "Neostigmine and 4-aminopyridine antagonism of lincomycin-pancuronium neuromuscular blockade in man." Anesth Analg 57 (1978): 316-21. [PMID: 566050]
11	Canadian Pharmacists Association.
12	Cerner Multum, Inc. "Australian Product Information.".
13	de Gouw NE, Crul JF, Vandermeersch E, Mulier JP, van Egmond J, Van Aken H "Interaction of antibiotics on pipecuronium-induced neuromuscular blockade." J Clin Anesth 5 (1993): 212-5. [PMID: 8391282]
14	Fogdall RP, Miller RD "Antagonism of d-tubocurarine- and pancuronium-induced neuromuscular blockades by pyridostigmine in man." Anesthesiology 39 (1973): 504-9. [PMID: 4355635]
15	Jedeikin R, Dolgunski E, Kaplan R, Hoffman S "Prolongation of neuromuscular blocking effect of vecuronium by antibiotics." Anaesthesia 42 (1987): 858-60. [PMID: 2889390]
16	Product Information. Clindesse (clindamycin topical). Ther-Rx Corporation, Bridgeton, MO.
17	Product Information. Lincocin (lincomycin). Pharmacia and Upjohn, Kalamazoo, MI.
18	Rubbo JT, Gergis SD, Sokoll MD "Comparative neuromuscular effects of lincomycin and clindamycin." Anesth Analg 56 (1977): 329-32. [PMID: 194504]
19	Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
20	Albert KS, DeSante KA, Welch RD, DiSanto AR "Pharmacokinetic evaluation of a drug interaction between kaolin-pectin and clindamycin." J Pharm Sci 67 (1978): 1579-82. [PMID: 712595]
21	McCall CE, Steigbigel NH, Finland M "Lincomycin: activity in vitro and absorption and excretion in normal young men." Am J Med Sci 254 (1967): 144-55. [PMID: 4951792]
22	McGehee RF Jr, Smith CB, Wilcox C, Finland M "Comparative studies of antibacterial activity in vitro and absorption and excretion of lincomycin and clindamycin." Am J Med Sci 256 (1968): 279-92. [PMID: 4386950]
23	Product Information. Indium Oxyquinoline In-111 (indium oxyquinoline In-111). GE Healthcare, Princeton, NJ.
24	Product Information. Trikafta (elexacaftor/ivacaftor/tezacaftor). Vertex Pharmaceuticals, Cambridge, MA.
25	Back DJ, Breckenridge AM, Crawford FE, MacIver M, Orne ML, Rowe PH "Interindividual variation and drug interactions with hormonal steroid contraceptives." Drugs 21 (1981): 46-61. [PMID: 7009137]
26	Barnett ML "Inhibition of oral contraceptive effectiveness by concurrent antibiotic administration." J Periodontol 56 (1985): 18-20. [PMID: 3882930]
27	King VJ "OC failure rates and oral antibiotics." J Fam Pract 45 (1997): 104-5. [PMID: 9267366]
28	Product Information. Prepopik (citric acid/Mg oxide/Na picosulfate). Ferring Pharmaceuticals Inc, Tarrytown, NY.
29	MHRA. Medicines and Healthcare Regulatory Agency (general site Reference).
30	Product Information. Clenpiq (citric acid/Mg oxide/Na picosulfate). Ferring Pharmaceuticals Inc, Tarrytown, NY.
31	Hardman JG, Gilman AG, Limbird LE eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 9th ed." New York, NY: McGraw-Hill (1995):.
32	Product Information. CellCept (mycophenolate mofetil). Roche Laboratories, Nutley, NJ.
33	Product Information. Myfortic (mycophenolic acid). Novartis Pharmaceuticals, East Hanover, NJ.
34	Kishore K, Raina A, Misra V, Jonas E "Acute verapamil toxicity in a patient with chronic toxicity: possible interaction with ceftriaxone and clindamycin." Ann Pharmacother 27 (1993): 877-80. [PMID: 8364267]
35	Brause BD, Romankiewicz JA, Gotz V, Franklin JE Jr, Roberts RB "Comparative study of diarrhea associated with clindamycin and ampicillin therapy." Am J Gastroenterol 73 (1980): 244-8. [PMID: 7405925]

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