Drug General Information (ID: DDIIV5PO43)
Drug Name			Verapamil		Drug Info		Clindamycin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Analgesics				Antibiotics
Structure

Mechanism of Verapamil-Clindamycin Interaction (Severity Level: Moderate)
Competitive binding of plasma proteins Click to Show/Hide Mechanism Graph
Drug Name		Verapamil				Clindamycin
Mechanism		Competition for plasma protein binding sites				Competition for plasma protein binding sites
Key Mechanism Factor 1
		Factor Name		Plasma protein binding
		Factor Description		Plasma protein binding refers to the degree of binding of a drug to proteins in the blood, and the lower the degree of binding, the more efficiently the drug can cross cell membranes or diffuse. Plasma protein binding alters the distribution and therapeutic characteristics of the drugs.
Mechanism Description		Increased plasma concentration of Clindamycin and Verapamil due to competitive binding of plasma proteins

Recommended Action
Management		Until more information is available, patients should be monitored for verapamil toxicity.

References
1	Kishore K, Raina A, Misra V, Jonas E "Acute verapamil toxicity in a patient with chronic toxicity: possible interaction with ceftriaxone and clindamycin." Ann Pharmacother 27 (1993): 877-80. [PMID: 8364267]