Drug General Information (ID: DDIEMPTH4Y)
Drug Name			Erythromycin		Drug Info		Clindamycin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antibiotics				Antibiotics
Structure

Mechanism of Erythromycin-Clindamycin Interaction (Severity Level: Moderate)
Competitive binding of the 50S ribosomal subunit Click to Show/Hide Mechanism Graph
Drug Name		Erythromycin				Clindamycin
Mechanism		Competitive binding of the 50S ribosomal subunit				Competitive binding of the 50S ribosomal subunit
Key Mechanism Factor 1
		Factor Name		50S ribosomal subunit
		Factor Description		Lincomycin derivatives and macrolides both exert antibacterial effects by targeting the 50S ribosomal subunit, and combined use may result in reduced antibacterial effects.
Mechanism Description		Competitive binding of the 50S ribosomal subunit when Erythromycin and Clindamycin are combined

Recommended Action
Management		Clindamycin or lincomycin should not be used concurrently with erythromycin.

References
1	Hardman JG, Gilman AG, Limbird LE eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 9th ed." New York, NY: McGraw-Hill (1995):.
2	Product Information. Cleocin (clindamycin). Pharmacia and Upjohn, Kalamazoo, MI.