Drug General Information (ID: DDIE8GRX9S)
Drug Name			Clindamycin		Drug Info		Attapulgite		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antibiotics				Antidiarrheals
Structure

Mechanism of Clindamycin-Attapulgite Interaction (Severity Level: Moderate)
Adsorption Click to Show/Hide Mechanism Graph
Drug Name		Clindamycin				Attapulgite
Mechanism		Adsorbed by adsorbent antidiarrheal agents				Adsorbent antidiarrheal agents
Key Mechanism Factor 1
		Factor Name		Adsorption
		Factor Description		Adsorption is a direct drug interaction, usually through adsorption on its surface, resulting in reduced absorption of concomitantly administered drugs in the gastrointestinal tract.
Mechanism Description		Decreased absorption of Clindamycin due to adsorption of Attapulgite

Recommended Action
Management		The use of adsorbent antidiarrheals should be avoided if possible. If used concurrently, the patient should be monitored closely for loss of antibiotic efficacy.

References
1	Albert KS, DeSante KA, Welch RD, DiSanto AR "Pharmacokinetic evaluation of a drug interaction between kaolin-pectin and clindamycin." J Pharm Sci 67 (1978): 1579-82. [PMID: 712595]
2	McCall CE, Steigbigel NH, Finland M "Lincomycin: activity in vitro and absorption and excretion in normal young men." Am J Med Sci 254 (1967): 144-55. [PMID: 4951792]
3	McGehee RF Jr, Smith CB, Wilcox C, Finland M "Comparative studies of antibacterial activity in vitro and absorption and excretion of lincomycin and clindamycin." Am J Med Sci 256 (1968): 279-92. [PMID: 4386950]
4	Product Information. Cleocin (clindamycin). Pharmacia and Upjohn, Kalamazoo, MI.
5	Product Information. Lincocin (lincomycin). Pharmacia and Upjohn, Kalamazoo, MI.