Details of Drug

Drug General Information (ID: D0125)
Drug Name	Attapulgite
Drug Type	Small molecule
Drug Synonymous	Parepectolin; Palygorskit; Palygorskite; Actapulgite; Permagel; Attagel; Rheaban; Attasorb; Attacote; Attaclay; Diluex; Zeogel; Toxi-sorb bolus; Clay, attapulgite; Pharmasorb-colloidal; Attagel 40; Attagel 50; Attagel 150; Toxi-sorb calf bolus; Attapulgite-type clay; Min-U-Gel FG; Palygorskit [German]; Attaclay X 250; RVM-FG; Min-U-Gel 200; Min-U-Gel 400; 200U/P-Rvm; Palygorskite fibres (<5 um); Attapulgite, activated [USP]; HSDB 410; Polygorskite fibers (> 5 um in length); X 250; Long palygorskite (attapulgite) fibres (>5 um) Click to Show/Hide
Disease Class	ME05: Bowel habit change
Therapeutic Class	Antidiarrheals
Structure
Structure	3D Structure		2D Structure
Formula	Al2H29Mg2O15Si4-
InChI	1S/2Al.2Mg.15H2O.4Si/h;;;;15*1H2;;;;/p-1
InChIKey	DGMCGTFMFPEQLT-UHFFFAOYSA-M
Canonical SMILES	O.O.O.O.O.O.O.O.O.O.O.O.O.O.[OH-].[Mg].[Mg].[Al].[Al].[Si].[Si].[Si].[Si]
External Link
	Pubchem ID	56842194
	CAS Number	12174-11-7
	TTD ID	D0DF9Z

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM006 Pharmacodynamic additive effects BM003 Complex formation BM004 Adsorption BM009 Altered absorption (Unspecific) BM035 Additive antimotility effects BM038 Additive CNS depression effects
Relation Graph

Full list of drugs interacting with Attapulgite
Affected gastrointestinal absorption
	Complex formation					Drug Num: 40
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0181		Bictegravir	C21H18F3N3O5	90311989	Major		Inter Info	[1], [2], [3]
D0515		Dolutegravir	C20H19F2N3O5	54726191	Major		Inter Info	[4]
D0034		Alendronic acid	C4H13NO7P2	2088	Moderate		Inter Info	[5], [6], [7]
D0144		Baloxavir marboxil	C27H23F2N3O7S	124081896	Moderate		Inter Info	[9]
D0433		Deferiprone	C7H9NO2	2972	Moderate		Inter Info	[10]
D0438		Delafloxacin	C18H12ClF3N4O4	487101	Moderate		Inter Info	[11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42]
D0561		Eltrombopag	C25H22N4O4	135449332	Moderate		Inter Info	[2], [43]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Moderate		Inter Info	[1], [2], [44], [45], [46], [47], [48], [49]
D1175		Omadacycline	C29H40N4O7	54697325	Moderate		Inter Info	[55], [56], [57]
D1445		Sarecycline	C24H29N3O8	54681908	Moderate		Inter Info	[58], [44], [59], [55], [60], [61], [56], [62], [63], [64], [32], [57], [42]
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[1], [2], [44], [45], [46], [47], [48], [49]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Moderate		Inter Info	[11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42]
D0441		Demeclocycline	C21H21ClN2O8	54680690	Moderate		Inter Info	[58], [44], [59], [55], [60], [61], [56], [62], [63], [64], [32], [57], [42]
D0530		Doxycycline	C22H24N2O8	54671203	Moderate		Inter Info	[58], [44], [59], [55], [60], [61], [56], [62], [63], [64], [32], [57], [42]
D0623		Etidronic acid	C2H8O7P2	3305	Moderate		Inter Info	[6], [65], [7]
D0712		Gatifloxacin	C19H22FN3O4	5379	Moderate		Inter Info	[24], [25], [38]
D0716		Gemifloxacin	C18H20FN5O4	9571107	Moderate		Inter Info	[11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42]
D0783		Ibandronate	C9H23NO7P2	60852	Moderate		Inter Info	[66], [67], [5], [6], [68], [7]
D0919		Levofloxacin	C18H20FN3O4	149096	Moderate		Inter Info	[11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42]
D1070		Minocycline	C23H27N3O7	54675783	Moderate		Inter Info	[58], [44], [59], [55], [60], [61], [56], [62], [63], [64], [32], [57], [42]
D1092		Moxifloxacin	C21H24FN3O4	152946	Moderate		Inter Info	[11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42]
D1155		Norfloxacin	C16H18FN3O3	4539	Moderate		Inter Info	[24], [25], [38]
D1165		Ofloxacin	C18H20FN3O4	4583	Moderate		Inter Info	[11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42]
D1245		Penicillamine	C5H11NO2S	5852	Moderate		Inter Info	[69], [70], [71], [72], [73], [74], [75], [32]
D1412		Risedronic acid	C7H11NO7P2	5245	Moderate		Inter Info	[5], [6], [7]
D1564		Tetracycline	C22H24N2O8	54675776	Moderate		Inter Info	[58], [44], [59], [55], [60], [61], [56], [62], [63], [64], [32], [57], [42]
D1657		Trovafloxacin	C20H15F3N4O3	62959	Moderate		Inter Info	[24], [25], [38]
D0010		Acebutolol	C18H28N2O4	1978	Minor		Inter Info	[44], [76], [77], [78], [79], [80], [81]
D0117		Atenolol	C14H22N2O3	2249	Minor		Inter Info	[44], [76], [77], [78], [79], [80], [81]
D1114		Nebivolol	C22H25F2NO4	71301	Minor		Inter Info	[44], [76], [77], [78], [79], [80], [81]
D0173		Betaxolol	C18H29NO3	2369	Minor		Inter Info	[44], [76], [77], [78], [79], [80], [81]
D0188		Bisoprolol	C18H31NO4	2405	Minor		Inter Info	[44], [76], [77], [78], [79], [80], [81]
D0267		Carvedilol	C24H26N2O4	2585	Minor		Inter Info	[44], [76], [77], [78], [79], [80], [81]
D0884		Labetalol	C19H24N2O3	3869	Minor		Inter Info	[44], [76], [77], [78], [79], [80], [81]
D1049		Metoprolol	C15H25NO3	4171	Minor		Inter Info	[44], [76], [77], [78], [79], [80], [81]
D1098		Nadolol	C17H27NO4	39147	Minor		Inter Info	[44], [76], [77], [78], [79], [80], [81]
D1293		Pindolol	C14H20N2O2	4828	Minor		Inter Info	[44], [76], [77], [78], [79], [80], [81]
D1357		Propranolol	C16H21NO2	4946	Minor		Inter Info	[44], [76], [77], [78], [79], [80], [81]
D1498		Sotalol	C12H20N2O3S	5253	Minor		Inter Info	[44], [76], [77], [78], [79], [80], [81]
D1585		Timolol	C13H24N4O3S	33624	Minor		Inter Info	[44], [76], [77], [78], [79], [80], [81]
	Adsorption					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0931		Lincomycin	C18H34N2O6S	3000540	Moderate		Inter Info	[50], [51], [52], [53], [54]
D0354		Clindamycin	C18H33ClN2O5S	446598	Moderate		Inter Info	[50], [51], [52], [53], [54]
	Altered absorption (Unspecific)					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0040		Allopurinol	C5H4N4O	135401907	Moderate		Inter Info	[1], [2], [8]
D0489		Diflunisal	C13H8F2O3	3059	Minor		Inter Info	[44], [82], [83]
D0858		Isoniazid	C6H7N3O	3767	Minor		Inter Info	[84], [85]
Pharmacodynamic additive effects
	Additive antimotility effects					Drug Num: 11
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0226		Butorphanol	C21H29NO2	5361092	Moderate		Inter Info	[2]
D0379		Codeine	C18H21NO3	5284371	Moderate		Inter Info	[2]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[2]
D0776		Hydromorphone	C17H19NO3	5284570	Moderate		Inter Info	[2]
D0923		Levorphanol	C17H23NO	5359272	Moderate		Inter Info	[2]
D1001		Meperidine	C15H21NO2	4058	Moderate		Inter Info	[2]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[2]
D1089		Morphine	C17H19NO3	5288826	Moderate		Inter Info	[2]
D1100		Nalbuphine	C21H27NO4	5311304	Moderate		Inter Info	[2]
D1203		Oxycodone	C18H21NO4	5284603	Moderate		Inter Info	[2]
D1208		Oxymorphone	C17H19NO4	5284604	Moderate		Inter Info	[2]
	Additive CNS depression effects					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0161		Benzhydrocodone	C25H25NO4	49836084	Moderate		Inter Info	[2]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[2]
D1183		Opium	NA	NA	Moderate		Inter Info	[2]

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