Drug General Information (ID: DDI7DQ3UFN)
Drug Name			Ampicillin		Drug Info		Clindamycin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antibiotics				Antibiotics
Structure

Mechanism of Ampicillin-Clindamycin Interaction (Severity Level: Minor)
Increased risk of intestinal flora disorders Click to Show/Hide Mechanism Graph
Drug Name		Ampicillin				Clindamycin
Mechanism		Intestinal flora disorders				Intestinal flora disorders
Key Mechanism Factor 1
		Factor Name		Intestinal flora disorders
		Factor Description		Maintaining the balance of intestinal flora is important for human health. Disturbed intestinal flora may lead to constipation, diarrhea, lowered immunity and other age-related diseases.
Mechanism Description		Increased risk of intestinal flora disorders by the combination of Ampicillin and Clindamycin

References
1	Brause BD, Romankiewicz JA, Gotz V, Franklin JE Jr, Roberts RB "Comparative study of diarrhea associated with clindamycin and ampicillin therapy." Am J Gastroenterol 73 (1980): 244-8. [PMID: 7405925]