Details of Drug

Drug General Information (ID: D1605)
Drug Name	Tolevamer
Drug Type	Small molecule
Drug Synonymous	Tolevamer; SCHEMBL13423754 Click to Show/Hide
Therapeutic Class	Potassium-Binding Resin
Structure
Structure	3D Structure		2D Structure
Formula	C11H16O3S
InChI	InChI=1S/C11H16O3S/c1-3-9(4-2)10-5-7-11(8-6-10)15(12,13)14/h5-9H,3-4H2,1-2H3,(H,12,13,14)
InChIKey	LZNNAMNPSXBDOT-UHFFFAOYSA-N
Canonical SMILES	CCC(CC)C1=CC=C(C=C1)S(=O)(=O)O
External Link
External Link	Pubchem ID	58817179

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM006 Pharmacodynamic additive effects BM003 Complex formation BM065 Increased risk of hypokalemia BM066 Increased risk of hypomagnesemia BM076 Increased risk of prolong QT interval BM081 Increased risk of ventricular arrhythmias BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Tolevamer
Affected gastrointestinal absorption
	Complex formation					Drug Num: 12
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0049		Aluminum hydroxide	AlH3O3	10176082	Major		Inter Info	[18], [19], [20]
D0236		Calcium carbonate	CCaO3	10112	Major		Inter Info	[18], [19], [20]
D0967		Magaldrate	AlHMgO5S+2	3086011	Major		Inter Info	[18], [19], [20]
D0968		Magnesium carbonate	CMgO3	11029	Major		Inter Info	[18], [19], [20]
D0973		Magnesium hydroxide	H2MgO2	14791	Major		Inter Info	[18], [19], [20]
D0974		Magnesium oxide	MgO	14792	Major		Inter Info	[18], [19], [20]
D0925		Levothyroxine	C15H11I4NO4	5819	Moderate		Inter Info	[33], [13], [34]
D0934		Liothyronine	C15H12I3NO4	5920	Moderate		Inter Info	[33], [13], [34]
D1369		Quinapril	C25H30N2O5	54892	Moderate		Inter Info	[29], [35], [36]
D0935		Liotrix	C30H21I7N2Na2O8	71371	Moderate		Inter Info	[33], [13], [34]
D0940		Lithium carbonate	CLi2O3	11125	Moderate		Inter Info	[22], [13], [18]
D1577		Thyroid, porcine	NA	NA	Moderate		Inter Info	[33], [13], [34]
Pharmacodynamic additive effects
	Increased risk of hypokalemia					Drug Num: 14
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0148		Beclomethasone dipropionate	C28H37ClO7	21700	Moderate		Inter Info	[25], [26], [27]
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[25], [26], [27]
D0392		Corticotropin	C207H308N56O58S	16132265	Moderate		Inter Info	[25], [26], [27]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[25], [26], [27]
D0671		Fludrocortisone	C21H29FO5	31378	Moderate		Inter Info	[25], [26], [27]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[25], [26], [27]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[25], [26], [27]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[25], [26], [27]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[25], [26], [27]
D1563		Tetracosactide	C136H210N40O31S	16133802	Moderate		Inter Info	[25], [26], [27]
D0436		Deflazacort	C25H31NO6	189821	Moderate		Inter Info	[25], [26], [27]
D0490		Digitoxin	C41H64O13	441207	Moderate		Inter Info	[29], [13]
D0926		Licorice	C42H62O16Zn	163463	Moderate		Inter Info	[37], [38], [39]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[25], [26], [27]
	Increased risk of hypomagnesemia					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0603		Esomeprazole	C17H19N3O3S	9568614	Moderate		Inter Info	[30], [31], [32]
D0892		Lansoprazole	C16H14F3N3O2S	3883	Moderate		Inter Info	[30], [31], [32]
D1179		Omeprazole	C17H19N3O3S	4594	Moderate		Inter Info	[30], [31], [32]
D1222		Pantoprazole	C16H15F2N3O4S	4679	Moderate		Inter Info	[30], [31], [32]
D1373		Rabeprazole	C18H21N3O3S	5029	Moderate		Inter Info	[30], [31], [32]
D0458		Dexlansoprazole	C16H14F3N3O2S	9578005	Moderate		Inter Info	[30], [31], [32]
	Increased risk of prolong QT interval					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[10], [11], [12]
	Increased risk of ventricular arrhythmias					Drug Num: 17
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0066		Amiodarone	C25H29I2NO3	2157	Major		Inter Info	[1], [2], [3]
D0107		Arsenic trioxide	As2O3	14888	Major		Inter Info	[4], [5]
D0513		Dofetilide	C19H27N3O5S2	71329	Major		Inter Info	[6]
D0535		Droperidol	C22H22FN3O2	3168	Major		Inter Info	[7], [8], [9]
D1292		Pimozide	C28H29F2N3O	16362	Major		Inter Info	[16], [17]
D0534		Dronedarone	C31H44N2O5S	208898	Major		Inter Info	[21]
D1726		Ziprasidone	C21H21ClN4OS	60854	Major		Inter Info	[22], [23], [24]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[28], [29]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[28], [29]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[28], [29]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[28], [29]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[28], [29]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[28], [29]
D1574		Thioridazine	C21H26N2S2	5452	Moderate		Inter Info	[28], [29]
D0067		Amisulpride	C17H27N3O4S	2159	Moderate		Inter Info	[28], [29]
D0791		Iloperidone	C24H27FN2O4	71360	Moderate		Inter Info	[28], [29]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[28], [29]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0995		Meloxicam	C14H13N3O4S2	54677470	Major		Inter Info	[13], [14], [15]
D1893		Sorbitol	C6H14O6	5780	Major		Inter Info	[13], [14], [15]

References
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3	Product Information. Amiodarone Hydrochloride (amiodarone). Bedford Laboratories, Bedford, OH.
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12	Product Information. Xatral (alfuzosin). Sanofi-Synthelabo Canada Inc, Markham, ON.
13	Product Information. Kayexalate (sodium polystyrene sulfonate). Sanofi Winthrop Pharmaceuticals, New York, NY.
14	Product Information. Mobic (meloxicam) Boehringer-Ingelheim, Ridgefield, CT.
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17	Product Information. Orap Tablets (pimozide). Gate Pharmaceuticals, Sellersville, PA.
18	Product Information. Resonium Calcium (calcium polystyrene sulfonate). Sanofi-Synthelabo Canada Inc, Markham, ON.
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22	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
23	Product Information. Geodon (ziprasidone). Pfizer US Pharmaceuticals, New York, NY.
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27	Product Information. Hydeltrasol (prednisolone). Merck &amp Co, Inc, West Point, PA.
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34	Product Information. Synthroid (levothyroxine). Abbott Pharmaceutical, Abbott Park, IL.
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