Drug General Information (ID: DDIHI9E87W)
Drug Name			Tolevamer		Drug Info		Digitoxin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Potassium-Binding Resin				Antiarrhythmic Agents
Structure

Mechanism of Tolevamer-Digitoxin Interaction (Severity Level: Moderate)
Increased risk of hypokalemia Click to Show/Hide Mechanism Graph
Drug Name		Tolevamer				Digitoxin
Mechanism		Hypokalemia				Hypokalemia
Key Mechanism Factor 1
		Factor Name		Hypokalemia
		Factor Description		Hypokalemia is a condition in which the amount of potassium in your blood is lower than normal. If you are mildly hypokalemic, you may not have any signs or symptoms, but severe hypokalemia may have the following symptoms: fatigue, constipation, frequent or heavy urination, muscle cramps or skin tingling, muscle weakness, and a fast or irregular heartbeat.
Mechanism Description		Increased risk of hypokalemia by the combination of Tolevamer and Digitoxin

Recommended Action
Management		Serum potassium levels should be closely monitored if these agents must be coadministered.

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Product Information. Kayexalate (sodium polystyrene sulfonate). Sanofi Winthrop Pharmaceuticals, New York, NY.