Drug General Information (ID: DDI80SHUW4)
Drug Name			Tolevamer		Drug Info		Lithium carbonate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Potassium-Binding Resin				Antimanic Agents
Structure

Mechanism of Tolevamer-Lithium carbonate Interaction (Severity Level: Moderate)
Complex formation Click to Show/Hide Mechanism Graph
Drug Name		Tolevamer				Lithium carbonate
Mechanism		Cation exchange resin/polymer				Binds to cation exchange resin/polymer
Key Mechanism Factor 1
		Factor Name		Chelation
		Factor Description		Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption.
Mechanism Description		Decreased absorption of Tolevamer due to formation of complexes caused by Lithium carbonate

Recommended Action
Management		Patients should consider separating the times of administration of the cation-exchange resin and lithium by several hours if possible.

References
1	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
2	Product Information. Kayexalate (sodium polystyrene sulfonate). Sanofi Winthrop Pharmaceuticals, New York, NY.
3	Product Information. Resonium Calcium (calcium polystyrene sulfonate). Sanofi-Synthelabo Canada Inc, Markham, ON.