Details of Drug

Drug General Information (ID: D1517)
Drug Name	Sulfasalazine
Drug Type	Small molecule
Drug Synonymous	sulfasalazine; 599-79-1; Salicylazosulfapyridine; Salazosulfapyridine; Azulfidine; Asulfidine; Salazopyridin; Sulcolon; Azopyrin; Accucol; Colo-Pleon; Salazopiridazin; Salisulf; Reupirin; Benzosulfa; Azopyrine; Salazosulfapyridin; Sulfasalazina; w-t Sasp oral; Sulfasalazinum; Sulfasalazin; Azulfidine EN; Sulfazalazine; Azulfidine EN-tabs; Salazosulfapiridina; Sas-500; Salazosulfapyridinum; Azosulfidin; SASP; Salazo-sulfapyridinum; 5-(p-(2-Pyridylsulfamyl)phenylazo)salicylic acid; SAS-500; Sulfasalizine Click to Show/Hide
Disease Class	FA20: Rheumatoid arthritis; DD91: Irritable bowel syndrome
Therapeutic Class	Antiinflammatory Agents
Structure
Structure	3D Structure		2D Structure
Formula	C18H14N4O5S
InChI	1S/C18H14N4O5S/c23-16-9-6-13(11-15(16)18(24)25)21-20-12-4-7-14(8-5-12)28(26,27)22-17-3-1-2-10-19-17/h1-11,23H,(H,19,22)(H,24,25)
InChIKey	NCEXYHBECQHGNR-UHFFFAOYSA-N
Canonical SMILES	C1=CC=NC(=C1)NS(=O)(=O)C2=CC=C(C=C2)N=NC3=CC(=C(C=C3)O)C(=O)O
External Link
	Pubchem ID	5339
	CAS Number	599-79-1
	CHEBI ID	9334
	TTD ID	D02ZTJ
	INTEDE ID	DR1513
	VARIDT ID	DR00201

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM002 Affected cellular transport AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM005 Affected excretion pathways AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM002 Altered intestinal flora BM010 Transporter inhibition BM013 Competitive binding of plasma proteins BM014 Interference of cell/tissue uptake BM017 CYP450 enzyme inhibition BM018 Non-CYP450 enzyme inhibition BM027 Decreased renal excretion due to nephrotoxicity BM030 Competitive inhibition of bile excretion BM043 Additive immunosuppressive effects BM055 Increased risk of hepatotoxicity BM064 Increased risk of hypoglycemia BM071 Increased risk of methemoglobinemia BM072 Increased risk of nephrotoxicity BM075 Increased risk of photosensitivity reactions BM083 Potentiated the pharmacological effects (Unspecific) BM107 Attenuated pharmacological effects (Unspecific) BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Sulfasalazine
Affected gastrointestinal absorption
	Altered intestinal flora					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1094		Mycophenolate mofetil	C23H31NO7	5281078	Moderate		Inter Info	[213], [214]
D1095		Mycophenolic acid	C17H20O6	446541	Moderate		Inter Info	[213], [214]
Affected cellular transport
	Transporter inhibition					Drug Num: 18
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[19], [58]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[20], [232], [233]
D0251		Capmatinib	C23H17FN6O	25145656	Moderate		Inter Info	[235]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[20], [236]
D0425		Darolutamide	C19H19ClN6O2	67171867	Moderate		Inter Info	[237]
D0561		Eltrombopag	C25H22N4O4	135449332	Moderate		Inter Info	[238], [25], [19], [239], [240]
D0568		Enasidenib	C19H17F6N7O	89683805	Moderate		Inter Info	[19], [241]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[20], [242]
D0700		Fostemsavir	C25H26N7O8P	11319217	Moderate		Inter Info	[244]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[19], [20], [245]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[20], [246]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[252]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[20]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[19], [20]
D1407		Rimegepant	C28H28F2N6O3	51049968	Moderate		Inter Info	[256]
D1423		Rolapitant	C25H26F6N2O2	10311306	Moderate		Inter Info	[257]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[258]
D1539		Tedizolid	C17H15FN6O3	11234049	Moderate		Inter Info	[20], [259]
Affected organization distribution
	Competitive binding of plasma proteins					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0481		Dicoumarol	C19H12O6	54676038	Major		Inter Info	[12], [13], [14]
D0087		Anisindione	C16H12O3	2197	Major		Inter Info	[29], [30], [31], [32], [12], [33], [34], [35], [36], [37], [13], [38], [39], [40], [41], [42], [43], [44], [14], [45], [46]
D1711		Warfarin	C19H16O4	54678486	Major		Inter Info	[29], [30], [31], [32], [12], [33], [34], [35], [36], [37], [13], [38], [39], [40], [41], [42], [43], [44], [14], [45], [46]
	Interference of cell/tissue uptake					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1817		Indium In-111 oxyquinoline	C27H18InN3O3	16685037	Moderate		Inter Info	[248]
D1822		Iodide I-123	I-	135300	Moderate		Inter Info	[249], [250], [251]
Affected intra/extra-hepatic metabolism
	Non-CYP450 enzyme inhibition					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0136		Azathioprine	C9H7N7O2S	2265	Moderate		Inter Info	[222], [223], [224], [225], [226], [227], [228], [229]
D1007		Mercaptopurine	C5H4N4S	667490	Moderate		Inter Info	[222], [223], [224], [225], [226], [227], [228], [229]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[262], [226], [227]
Affected excretion pathways
	Decreased renal excretion due to nephrotoxicity					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0576		Entecavir	C12H15N5O3	135398508	Moderate		Inter Info	[182]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[216]
D1241		Pemetrexed	C20H21N5O6	135410875	Moderate		Inter Info	[218]
D0668		Flucytosine	C4H4FN3O	3366	Moderate		Inter Info	[243]
D1543		Telbivudine	C10H14N2O5	159269	Moderate		Inter Info	[260]
	Competitive inhibition of bile excretion					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1265		Phenobarbital	C12H12N2O3	4763	Minor		Inter Info	[264]
Pharmacodynamic additive effects
	Additive immunosuppressive effects					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[20], [50]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[50], [63]
	Increased risk of hepatotoxicity					Drug Num: 19
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[51]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[54]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[59]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[168], [169], [170], [19], [20], [171], [172], [173], [174], [175], [176], [177], [178]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[180], [181]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[205], [206], [207], [208]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[205], [206], [207], [208]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[20], [209]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[215]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[168], [169], [170], [19], [20], [171], [172], [173], [174], [175], [176], [177], [178]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[168], [169], [170], [19], [20], [171], [172], [173], [174], [175], [176], [177], [178]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[230]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[231]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[168], [169], [170], [19], [20], [171], [172], [173], [174], [175], [176], [177], [178]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[20], [234]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[247]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[205], [206], [207], [208]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[19], [20], [253], [254], [255]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[20], [261]
	Increased risk of hypoglycemia					Drug Num: 23
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [34], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [34], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [34], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163]
D0811		Insulin glargine	C267H404N72O78S6	118984454	Moderate		Inter Info	[64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [198], [75], [76], [77], [78], [79], [80], [81], [82], [84], [85], [86], [88], [89], [90], [91], [93], [94], [95], [97], [99], [100], [101], [102], [103], [104], [105], [106], [107], [109], [111], [113], [114], [115], [118], [119], [121], [122], [123], [125], [199], [127], [200], [201], [132], [202], [203], [138], [140], [141], [142], [144], [146], [148], [150], [151], [155], [156], [157], [158], [204], [159], [160], [162], [163]
D0813		Insulin human	C257H383N65O77S6	118984375	Moderate		Inter Info	[71], [127], [144]
D0814		Insulin human (inhalation, rapid acting)	C257H383N65O77S6	118984375	Moderate		Inter Info	[71], [127], [144]
D0815		Insulin human (isophane)	C257H383N65O77S6	118984375	Moderate		Inter Info	[71], [127], [144]
D0816		Insulin human (regular)	C257H383N65O77S6	118984375	Moderate		Inter Info	[71], [127], [144]
D0817		Insulin human (zinc extended)	C257H383N65O77S6	118984375	Moderate		Inter Info	[71], [127], [144]
D0818		Insulin human (zinc)	C257H383N65O77S6	118984375	Moderate		Inter Info	[71], [127], [144]
D0819		Insulin lispro	C257H389N65O77S6	16132438	Moderate		Inter Info	[64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [198], [75], [76], [77], [78], [79], [80], [81], [82], [84], [85], [86], [88], [89], [90], [91], [93], [94], [95], [97], [99], [100], [101], [102], [103], [104], [105], [106], [107], [109], [111], [113], [114], [115], [118], [119], [121], [122], [123], [125], [199], [127], [200], [201], [132], [202], [203], [138], [140], [141], [142], [144], [146], [148], [150], [151], [155], [156], [157], [158], [204], [159], [160], [162], [163]
D0820		Insulin lispro (protamine)	C257H389N65O77S6	16132438	Moderate		Inter Info	[71], [127], [144]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [34], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [34], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [34], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163]
D0807		Insulin aspart (aspart protamine)	C256H381N65O79S6	118984445	Moderate		Inter Info	[71], [127], [144]
D0808		Insulin aspart (aspart)	C256H381N65O79S6	118984445	Moderate		Inter Info	[71], [127], [144]
D0809		Insulin degludec	C274H411N65O81S6	118984462	Moderate		Inter Info	[64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [198], [75], [76], [77], [78], [79], [80], [81], [82], [84], [85], [86], [88], [89], [90], [91], [93], [94], [95], [97], [99], [100], [101], [102], [103], [104], [105], [106], [107], [109], [111], [113], [114], [115], [118], [119], [121], [122], [123], [125], [199], [127], [200], [201], [132], [202], [203], [138], [140], [141], [142], [144], [146], [148], [150], [151], [155], [156], [157], [158], [204], [159], [160], [162], [163]
D0810		Insulin detemir	C267H402N64O76S6	16137271	Moderate		Inter Info	[64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [198], [75], [76], [77], [78], [79], [80], [81], [82], [84], [85], [86], [88], [89], [90], [91], [93], [94], [95], [97], [99], [100], [101], [102], [103], [104], [105], [106], [107], [109], [111], [113], [114], [115], [118], [119], [121], [122], [123], [125], [199], [127], [200], [201], [132], [202], [203], [138], [140], [141], [142], [144], [146], [148], [150], [151], [155], [156], [157], [158], [204], [159], [160], [162], [163]
D0812		Insulin glulisine	C258H384N64O78S6	16136701	Moderate		Inter Info	[64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [198], [75], [76], [77], [78], [79], [80], [81], [82], [84], [85], [86], [88], [89], [90], [91], [93], [94], [95], [97], [99], [100], [101], [102], [103], [104], [105], [106], [107], [109], [111], [113], [114], [115], [118], [119], [121], [122], [123], [125], [199], [127], [200], [201], [132], [202], [203], [138], [140], [141], [142], [144], [146], [148], [150], [151], [155], [156], [157], [158], [204], [159], [160], [162], [163]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [34], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [34], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88], [89], [90], [91], [92], [93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [34], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163]
	Increased risk of methemoglobinemia					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1337		Prilocaine	C13H20N2O	4906	Major		Inter Info	[18], [19], [20], [21], [22], [23], [24]
D1338		Prilocaine (topical)	C13H20N2O	4906	Major		Inter Info	[25], [19], [24]
D1148		Nitrous acid	HNO2	24529	Major		Inter Info	[55], [56], [57]
D1344		Procaine	C13H20N2O2	4914	Moderate		Inter Info	[20]
D0319		Chloroprocaine	C13H19ClN2O2	8612	Moderate		Inter Info	[20]
D1561		Tetracaine	C15H24N2O2	5411	Moderate		Inter Info	[20]
	Increased risk of nephrotoxicity					Drug Num: 77
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0335		Cidofovir	C8H14N3O6P	60613	Major		Inter Info	[1]
D0402		Cyclosporine	C62H111N11O12	5284373	Major		Inter Info	[2], [3], [4]
D0472		Diatrizoate	C11H9I3N2O4	2140	Major		Inter Info	[5], [6], [7], [8], [9], [10], [11]
D0765		Human immunoglobulin G (intravenous)	NA	NA	Major		Inter Info	[15], [16], [17]
D0432		Deferasirox	C21H15N3O4	214348	Major		Inter Info	[47], [48]
D0761		Human botulinum neurotoxin A/B immune globulin	NA	NA	Major		Inter Info	[15], [16], [17]
D0763		Human cytomegalovirus immune globulin	NA	NA	Major		Inter Info	[15], [16], [17]
D0768		Human Rho(D) immune globulin	NA	NA	Major		Inter Info	[15], [16], [17]
D0805		Inotersen	C230H318N69O121P19S19	121492004	Major		Inter Info	[20], [49]
D0831		Iodipamide	C20H14I6N2O6	3739	Major		Inter Info	[5], [6], [7], [8], [9], [10], [11]
D0832		Iodixanol	C35H44I6N6O15	3724	Major		Inter Info	[5], [6], [7], [8], [9], [10], [11]
D0833		Iohexol	C19H26I3N3O9	3730	Major		Inter Info	[5], [6], [7], [8], [9], [10], [11]
D0834		Iopamidol	C17H22I3N3O8	65492	Major		Inter Info	[5], [6], [7], [8], [9], [10], [11]
D0836		Iopromide	C18H24I3N3O8	3736	Major		Inter Info	[5], [6], [7], [8], [9], [10], [11]
D0837		Iothalamic acid	C11H9I3N2O4	3737	Major		Inter Info	[7], [8], [9]
D0838		Ioversol	C18H24I3N3O9	3741	Major		Inter Info	[5], [6], [7], [8], [9], [10], [11]
D0839		Ioxilan	C18H24I3N3O8	3743	Major		Inter Info	[5], [6], [7], [8], [9], [10], [11]
D1476		Sirolimus	C51H79NO13	5284616	Major		Inter Info	[60], [61], [62]
D1526		Tacrolimus	C44H69NO12	445643	Major		Inter Info	[60], [61], [62]
D0022		Acyclovir	C8H11N5O3	135398513	Moderate		Inter Info	[164], [165], [166], [167]
D0056		Amikacin	C22H43N5O13	37768	Moderate		Inter Info	[164], [165], [166], [167]
D0057		Amikacin (liposome)	C22H43N5O13	37768	Moderate		Inter Info	[165], [166], [167]
D0075		Amphotericin B	C47H73NO17	5280965	Moderate		Inter Info	[164], [165], [166], [167]
D0076		Amphotericin B (cholesteryl sulfate)	C47H73NO17	5280965	Moderate		Inter Info	[165], [166], [167]
D0077		Amphotericin B (lipid complex)	C47H73NO17	5280965	Moderate		Inter Info	[165], [166], [167]
D0078		Amphotericin B (liposomal)	C47H73NO17	5280965	Moderate		Inter Info	[165], [166], [167]
D0142		Bacitracin	C66H103N17O16S	10909430	Moderate		Inter Info	[164], [165], [166], [167]
D0252		Capreomycin	C50H88N28O15	3000502	Moderate		Inter Info	[164], [165], [166], [167]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[164], [165], [166], [167]
D0344		Cisplatin	Cl2H6N2Pt	5702198	Moderate		Inter Info	[164], [165], [166], [167]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[179]
D0476		Diclofenac	C14H11Cl2NO2	3033	Moderate		Inter Info	[164], [165], [166], [167]
D0624		Etodolac	C17H21NO3	3308	Moderate		Inter Info	[164], [165], [166], [167]
D0645		Fenoprofen	C15H14O3	3342	Moderate		Inter Info	[164], [165], [166], [167]
D0680		Flurbiprofen	C15H13FO2	3394	Moderate		Inter Info	[164], [165], [166], [167]
D0694		Foscarnet	CH3O5P	3415	Moderate		Inter Info	[164], [165], [166], [167]
D0783		Ibandronate	C9H23NO7P2	60852	Moderate		Inter Info	[186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197]
D0800		Indomethacin	C19H16ClNO4	3715	Moderate		Inter Info	[164], [165], [166], [167]
D0882		Ketorolac	C15H13NO3	3826	Moderate		Inter Info	[164], [165], [166], [167]
D0991		Mefenamic acid	C15H15NO2	4044	Moderate		Inter Info	[164], [165], [166], [167]
D1097		Nabumetone	C15H16O2	4409	Moderate		Inter Info	[164], [165], [166], [167]
D1109		Naproxen	C14H14O3	156391	Moderate		Inter Info	[164], [165], [166], [167]
D1217		Pamidronic acid	C3H11NO7P2	4674	Moderate		Inter Info	[217], [189], [196]
D1246		Pentamidine	C19H24N4O2	4735	Moderate		Inter Info	[164], [165], [166], [167]
D1300		Piroxicam	C15H13N3O4S	54676228	Moderate		Inter Info	[164], [165], [166], [167]
D1310		Polymyxin B	C56H98N16O13	49800004	Moderate		Inter Info	[164], [165], [166], [167]
D1421		Rofecoxib	C17H14O4S	5090	Moderate		Inter Info	[164], [165], [166], [167]
D0210		Bromfenac	C15H12BrNO3	60726	Moderate		Inter Info	[164], [165], [166], [167]
D0383		Colistimethate	C58H105N16O28S5-5	70789202	Moderate		Inter Info	[164], [165], [166], [167]
D0489		Diflunisal	C13H8F2O3	3059	Moderate		Inter Info	[164], [165], [166], [167]
D0709		Gallium nitrate	GaN3O9	61635	Moderate		Inter Info	[164], [165], [166], [167]
D0718		Gentamicin	C21H43N5O7	3467	Moderate		Inter Info	[164], [165], [166], [167]
D0724		Givosiran	C78H139N11O30	119058042	Moderate		Inter Info	[164], [165], [166], [167]
D0786		Ibuprofen	C13H18O2	3672	Moderate		Inter Info	[164], [165], [166], [167]
D0829		Iobenguane (I-131)	C8H10IN3	60860	Moderate		Inter Info	[165], [166], [167]
D0876		Kanamycin	C18H36N4O11	6032	Moderate		Inter Info	[164], [165], [166], [167]
D0881		Ketoprofen	C16H14O3	3825	Moderate		Inter Info	[164], [165], [166], [167]
D0940		Lithium carbonate	CLi2O3	11125	Moderate		Inter Info	[165], [166], [167]
D0964		Lutetium Lu 177 dotatate	C65H87LuN14O19S2	76966897	Moderate		Inter Info	[164], [165], [166], [167]
D0988		Meclofenamic acid	C14H11Cl2NO2	4037	Moderate		Inter Info	[165], [166], [167]
D0995		Meloxicam	C14H13N3O4S2	54677470	Moderate		Inter Info	[164], [165], [166], [167]
D1030		Methoxyflurane	C3H4Cl2F2O	4116	Moderate		Inter Info	[164], [165], [166], [167]
D1091		Moxetumomab Pasudotox	NA	NA	Moderate		Inter Info	[164], [165], [166], [167]
D1120		Neomycin	C23H46N6O13	8378	Moderate		Inter Info	[164], [165], [166], [167]
D1126		Netilmicin	C21H41N5O7	441306	Moderate		Inter Info	[164], [165], [166], [167]
D1196		Oxaprozin	C18H15NO3	4614	Moderate		Inter Info	[164], [165], [166], [167]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[164], [165], [166], [167]
D1442		Salsalate	C14H10O5	5161	Moderate		Inter Info	[164], [165], [166], [167]
D1507		Streptomycin	C21H39N7O12	19649	Moderate		Inter Info	[164], [165], [166], [167]
D1542		Telavancin	C80H106Cl2N11O27P	3081362	Moderate		Inter Info	[164], [165], [166], [167]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[164], [165], [166], [167]
D1520		Sulindac	C20H17FO3S	1548887	Moderate		Inter Info	[164], [165], [166], [167]
D1597		Tobramycin	C18H37N5O9	36294	Moderate		Inter Info	[164], [165], [166], [167]
D1606		Tolmetin	C15H15NO3	5509	Moderate		Inter Info	[164], [165], [166], [167]
D1672		Valaciclovir	C13H20N6O4	135398742	Moderate		Inter Info	[165], [166], [167]
D1674		Valdecoxib	C16H14N2O3S	119607	Moderate		Inter Info	[164], [165], [166], [167]
D1680		Vancomycin	C66H75Cl2N9O24	14969	Moderate		Inter Info	[164], [165], [166], [167]
	Increased risk of photosensitivity reactions					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0062		Aminolevulinic acid	C5H9NO3	137	Major		Inter Info	[27], [28]
D1028		Methoxsalen	C12H8O4	4114	Moderate		Inter Info	[19], [210], [27], [211], [212]
D1314		Porfimer sodium	C68H74N8O11	135577896	Moderate		Inter Info	[219], [20], [220]
D0063		Aminolevulinic acid (topical)	C5H9NO3	137	Moderate		Inter Info	[19], [20], [221]
D1033		Methyl aminolevulinate (topical)	C6H11NO3	157922	Moderate		Inter Info	[19], [20], [221]
D1691		Verteporfin	C82H84N8O16	11980904	Moderate		Inter Info	[20], [210], [27], [263]
	Potentiated the pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1366		Pyrimethamine	C12H13ClN4	4993	Moderate		Inter Info	[20], [210]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1020		Methenamine	C6H12N4	4101	Major		Inter Info	[52], [53]
Pharmacodynamic antagonistic effects
	Attenuated pharmacological effects (Unspecific)					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0059		Aminobenzoic acid	C7H7NO2	978	Major		Inter Info	[26]
D0606		Estradiol	C18H24O2	5757	Moderate		Inter Info	[183], [184], [185]
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[183], [184], [185]
D1011		Mestranol	C21H26O2	6291	Moderate		Inter Info	[183], [184], [185]

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126	Product Information. Amaryl (glimepiride). Hoechst Marion-Roussel Inc, Kansas City, MO.
127	Product Information. Apidra (insulin glulisine). Aventis Pharmaceuticals, Bridgewater, NJ.
128	Product Information. Diabeta (glyburide). Hoechst Marion-Roussel Inc, Kansas City, MO.
129	Product Information. Diabinese (chlorpropamide). Pfizer US Pharmaceuticals, New York, NY.
130	Product Information. Dymelor (acetohexamide) Lilly, Eli and Company, Indianapolis, IN.
131	Product Information. Glucotrol (glipizide). Pfizer US Pharmaceuticals, New York, NY.
132	Product Information. Increlex (mecasermin). Tercica Inc, Brisbane, CA.
133	Product Information. Micronase (glyburide). Pharmacia and Upjohn, Kalamazoo, MI.
134	Product Information. Orinase (tolbutamide) Pharmacia and Upjohn, Kalamazoo, MI.
135	Product Information. Prandin (repaglinide). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
136	Product Information. Starlix (nateglinide) Novartis Pharmaceuticals, East Hanover, NJ.
137	Product Information. Tolinase (tolazamide) Pharmacia and Upjohn, Kalamazoo, MI.
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166	Product Information. Lialda (mesalamine (5-aminosalicylic acid)). Shire US Inc, Florence, KY.
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174	Product Information. Asparlas (calaspargase pegol). Servier, Boston, MA.
175	Product Information. Elspar (asparaginase). Merck & Co, Inc, West Point, PA.
176	Product Information. Erwinaze (asparaginase Erwinia chrysanthemi). EUSA Pharma, Newtown, PA.
177	Product Information. Oncaspar (pegaspargase). Rhone-Poulenc Rorer, Collegeville, PA.
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181	Product Information. Sustiva (efavirenz). DuPont Pharmaceuticals, Wilmington, DE.
182	Product Information. Baraclude (entecavir). Bristol-Myers Squibb, Princeton, NJ.
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193	Product Information. Aredia (pamidronate). Novartis Pharmaceuticals, East Hanover, NJ.
194	Product Information. Boniva (ibandronate). Roche Laboratories, Nutley, NJ.
195	Product Information. Ostac (clodronate). Hoffmann-La Roche Limited, Mississauga, IA.
196	Product Information. Zometa (zoledronic acid). Novartis Pharmaceuticals, East Hanover, NJ.
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199	Product Information. Afrezza (insulin inhalation, rapid acting). MannKind Corporation, Valencia, CA.
200	Product Information. Humalog (insulin lispro). Lilly, Eli and Company, Indianapolis, IN.
201	Product Information. Humulin 70/30 (insulin isophane-insulin regular). Lilly, Eli and Company, Indianapolis, IN.
202	Product Information. Ryzodeg 70/30 FlexTouch (insulin aspart-insulin degludec). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
203	Product Information. Tresiba FlexTouch (insulin degludec). Novo Nordisk Pharmaceuticals Inc, Princeton, NJ.
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205	Product Information. Avonex (interferon beta-1a). Biogen, Cambridge, MA.
206	Product Information. Betaseron (interferon beta-1b). Berlex, Richmond, CA.
207	Product Information. Plegridy (peginterferon beta-1a). Biogen Idec Inc, Cambridge, MA.
208	Product Information. Rebif (interferon beta-1a). Serono Laboratories Inc, Norwell, MA.
209	Product Information. Methotrexate (methotrexate). Lederle Laboratories, Wayne, NJ.
210	Multum Information Services, Inc. Expert Review Panel.
211	Product Information. Oxsoralen (methoxsalen). ICN Pharmaceuticals Inc, Costa Mesa, CA.
212	Product Information. Uvadex (methoxsalen). Therakos Inc, Exton, PA.
213	Product Information. CellCept (mycophenolate mofetil). Roche Laboratories, Nutley, NJ.
214	Product Information. Myfortic (mycophenolic acid). Novartis Pharmaceuticals, East Hanover, NJ.
215	Product Information. ReVia (naltrexone). DuPont Pharmaceuticals, Wilmington, DE.
216	Product Information. Eloxatin (oxaliplatin). Sanofi Winthrop Pharmaceuticals, New York, NY.
217	Chang JT, Green L, Beitz J "Renal failure with the use of zoledronic acid." N Engl J Med 349 (2003): 1676-9 discussion 1676-9. [PMID: 14573746]
218	Product Information. Alimta (pemetrexed). Lilly, Eli and Company, Indianapolis, IN.
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