Drug General Information (ID: DDINDPXZE0)
Drug Name			Pyrimethamine		Drug Info		Sulfasalazine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antimalarial Agents				Antiinflammatory Agents
Structure

Mechanism of Pyrimethamine-Sulfasalazine Interaction (Severity Level: Moderate)
Potentiated the pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Pyrimethamine				Sulfasalazine
Mechanism		Antifolate effects				Antifolate effects Dihydropteroate synthetase  Substrate
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Enhanced pharmacological effects leading to increased adverse reactions.
Mechanism Description		Potentiate the pharmacologic effects by the combination of Pyrimethamine and Sulfasalazine

Recommended Action
Management		Periodic clinical and laboratory monitoring for signs of folic acid deficiency and hematologic changes is advisable.

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Multum Information Services, Inc. Expert Review Panel.