Details of Drug

Details of Drug

 Drug General Information (ID: D1366)
  Drug Name
Pyrimethamine
  Drug Type Small molecule
  Drug Synonymous
Chloridin; Chloridine; Chloridyn; Darachlor; Daraclor; Darapram; Daraprim; Daraprime; Daraprin; Diaminopyritamin; Erbaprelina; Ethylpyrimidine; Khloridin; Malacid; Malocid; Malocide; Maloprim; Pirimecidan; Pirimetamin; Pirimetamina; Primethamine; Pyremethamine; Pyrimethamin; Pyrimethaminum; Tindurin; Tindurine; Tinduring; Aventis Brand of Pyrimethamine; Glaxo Wellcome Brand of Pyrimethamine; GlaxoSmithKline Brand of Pyrimethamine; M alocid; Pirimetamina [Spanish]; Pyrimethamine Hcl; Wellcome Brand of Pyrimethamine; BW 5063; RP 4753; WR 2978; AZT + Pyrimethamine combination; BW 50-63; Daraprim (TN); EXR-101; Lactoferrin B & Pyrimethamine; Lactoferrin H & Pyrimethamine; Pirimetamina [INN-Spanish]; Pyrimethamine (Pyr); Pyrimethaminum [INN-Latin]; TCMDC-123831; TCMDC-125860; CRL-8131 & Pyrimethamine; CRL-8142 & Pyrimethamine; Fansidar (Pyrimethamine/Sulfadoxine); Pyrimethamine (JAN/USP/INN); Pyrimethamine [USAN:INN:BAN:JAN]; 2,4-Diamino-5-(4-chlorophenyl)-6-ethylpyrimidine; 2,4-Diamino-5-(p-chlorophenyl)-6-ethylpyrimidine; 2,4-Diamino-5-chlorophenyl-6-ethylpyrimidine; 5-(4'-Chlorophenyl)-2,4-diamino-6-ethylpyrimidine; 5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE; 5-(4-CHLOROPHENYL)-6-ETHYL-2,4-PYRIMIDINEDIAMINE; 5-(4-Chlorophenyl)-6-ethyl-2,4-diaminopyrimidine; 5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidi nediamine; 5-(4-chlorophenyl)-2,4-diamino-6-ethylpyrimidine; 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine; 5-(p-chlorophenyl)-6-ethyl-2,4-diaminopyrimidine; 5-[4-Chlorophenyl]-6-ethyl-2,4-pyrimidinediamine
    Click to Show/Hide
  Disease Class 1F40-1F45: Malaria
  Therapeutic Class Antimalarial Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C12H13ClN4
  InChI 1S/C12H13ClN4/c1-2-9-10(11(14)17-12(15)16-9)7-3-5-8(13)6-4-7/h3-6H,2H2,1H3,(H4,14,15,16,17)
  InChIKey WKSAUQYGYAYLPV-UHFFFAOYSA-N
  Canonical SMILES CCC1=C(C(=NC(=N1)N)N)C2=CC=C(C=C2)Cl
  External Link
Pubchem ID 4993
CAS Number 58-14-0
CHEBI ID 8673
TTD ID D0C0SK
VARIDT ID DR01272

Drug-Drug Interaction Network
  Sunburst Graph
AM001  Affected gastrointestinal absorption
AM003  Affected organization distribution
AM004  Affected intra/extra-hepatic metabolism
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM004  Adsorption
BM014  Interference of cell/tissue uptake
BM026  Increased metabolism (Unspecific)
BM043  Additive immunosuppressive effects
BM044  Additive myelosuppressive effects
BM083  Potentiated the pharmacological effects (Unspecific)
BM107  Attenuated pharmacological effects (Unspecific)
  Relation Graph
 Full list of drugs interacting with Pyrimethamine
      Affected gastrointestinal absorption
   Adsorption Drug Num:  6
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0049
 
Aluminum hydroxide
 
AlH3O3
 
10176082 
Moderate    Inter Info   
[7], [10]
D0236
 
Calcium carbonate
 
CCaO3
 
10112 
Moderate    Inter Info   
[7], [10]
D0877
 
Kaolin
 
Al2H4O9Si2
 
56841936 
Moderate    Inter Info   
[7], [10]
D0967
 
Magaldrate
 
AlHMgO5S+2
 
3086011 
Moderate    Inter Info   
[7], [10]
D0973
 
Magnesium hydroxide
 
H2MgO2
 
14791 
Moderate    Inter Info   
[7], [10]
D1480
 
Sodium bicarbonate
 
CHNaO3
 
516892 
Moderate    Inter Info   
[7], [10]
      Affected organization distribution
   Interference of cell/tissue uptake Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1822
 
Iodide I-123
 
I-
 
135300 
Moderate    Inter Info   
[12], [13], [14]
      Affected intra/extra-hepatic metabolism
   Increased metabolism (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1802
 
Glucarpidase
 
Zn4+8
 
21195079 
Moderate    Inter Info   
[7], [11]
      Pharmacodynamic additive effects
   Additive immunosuppressive effects Drug Num:  5
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1025
 
Methotrexate
 
C20H22N8O5
 
126941 
Moderate    Inter Info   
[7], [10]
D1323
 
Pralatrexate
 
C23H23N7O5
 
148121 
Moderate    Inter Info   
[7], [10]
D1350
 
Proguanil
 
C11H16ClN5
 
6178111 
Moderate    Inter Info   
[7], [10]
D1646
 
Trimetrexate
 
C19H23N5O3
 
5583 
Moderate    Inter Info   
[7], [10]
D1720
 
Zidovudine
 
C10H13N5O4
 
35370 
Moderate    Inter Info   
[7], [10]
   Additive myelosuppressive effects Drug Num:  4
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0126
 
Auranofin
 
C20H34AuO9PS
 
24199313 
Major    Inter Info   
[1], [2], [3]
D0127
 
Aurothioglucose
 
C6H11AuO5S
 
454937 
Major    Inter Info   
[1], [2], [3]
D0433
 
Deferiprone
 
C7H9NO2
 
2972 
Major    Inter Info   
[4], [5], [6]
D1479
 
Sodium aurothiomalate
 
C4H3AuNa2O4S
 
22318 
Major    Inter Info   
[1], [2], [3]
   Potentiated the pharmacological effects (Unspecific) Drug Num:  5
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1513
 
Sulfadiazine
 
C10H10N4O2S
 
5215 
Moderate    Inter Info   
[7], [10]
D1514
 
Sulfadoxine
 
C12H14N4O4S
 
17134 
Moderate    Inter Info   
[7], [10]
D1516
 
Sulfamethoxazole
 
C10H11N3O3S
 
5329 
Moderate    Inter Info   
[7], [10]
D1517
 
Sulfasalazine
 
C18H14N4O5S
 
5339 
Moderate    Inter Info   
[7], [10]
D1645
 
Trimethoprim
 
C14H18N4O3
 
5578 
Moderate    Inter Info   
[7], [10]
      Pharmacodynamic antagonistic effects
   Attenuated pharmacological effects (Unspecific) Drug Num:  2
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0688
 
Folic acid
 
C19H19N7O6
 
135398658 
Moderate    Inter Info   
[7], [8], [9]
D1884
 
Sapropterin
 
C9H15N5O3
 
135398654 
Moderate    Inter Info   
[4], [15]
References
1 Product Information. Myochrysine (gold sodium thiomaleate). Merck &amp Co, Inc, West Point, PA.
2 Product Information. Ridaura (auranofin). SmithKline Beecham, Philadelphia, PA.
3 Product Information. Solganal (aurothioglucose). Schering Laboratories, Kenilworth, NJ.
4 Cerner Multum, Inc. "Australian Product Information.".
5 Product Information. Ferriprox (deferiprone). ApoPharma USA Inc, Rockville, MD.
6 EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports."
7 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
8 Mulenga M, Malunga P, Bennett S. et.al "Folic acid treatment of Zambian children with moderate to severe malaria anemia." Am J Trop Med Hyg 74 (2006): 986-90
9 Product Information. Folic Acid (folic acid). Method Pharmaceuticals, LLC, Arlington, TX.
10 Multum Information Services, Inc. Expert Review Panel.
11 Product Information. Voraxaze (glucarpidase). BTG International Inc, West Conshohocken, PA.
12 Product Information. Rexulti (brexpiprazole). Otsuka American Pharmaceuticals Inc, Rockville, MD.
13 Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
14 Product Information. Sodium Iodide I-123 (sodium iodide I-123). GE Healthcare, Princeton, NJ.
15 Product Information. Kuvan (sapropterin). BioMarin Pharmaceutical Inc, Novato, CA.