Drug General Information (ID: DDIJK1OEGR)
Drug Name			Pyrimethamine		Drug Info		Kaolin		Drug Info
Drug Type		Small molecule				Natural product
Therapeutic Class		Antimalarial Agents				Herbal Products
Structure

Mechanism of Pyrimethamine-Kaolin Interaction (Severity Level: Moderate)
Adsorption Click to Show/Hide Mechanism Graph
Drug Name		Pyrimethamine				Kaolin
Mechanism		Adsorbed by adsorbent antidiarrheal agents				Adsorbent antidiarrheal agents
Key Mechanism Factor 1
		Factor Name		Adsorption
		Factor Description		Adsorption is a direct drug interaction, usually through adsorption on its surface, resulting in reduced absorption of concomitantly administered drugs in the gastrointestinal tract.
Mechanism Description		Decreased absorption of Pyrimethamine due to adsorption of Kaolin

Recommended Action
Management		Antacids and antidiarrheals should be taken at least 2 to 3 hours apart from pyrimethamine.

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Multum Information Services, Inc. Expert Review Panel.