Details of Drug-Drug Interaction
| Drug General Information (ID: DDI4K9ZDL3) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Drug Name | Pyrimethamine | Drug Info | Aluminum hydroxide | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Antimalarial Agents | Antacids | |||||||
| Structure | |||||||||
| Mechanism of Pyrimethamine-Aluminum hydroxide Interaction (Severity Level: Moderate) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Adsorption Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Pyrimethamine | Aluminum hydroxide | |||||||
| Mechanism | Adsorbed by antacids | Antacid | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Adsorption | ||||||||
| Factor Description | Adsorption is a direct drug interaction, usually through adsorption on its surface, resulting in reduced absorption of concomitantly administered drugs in the gastrointestinal tract. | ||||||||
| Mechanism Description |
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| Recommended Action | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Management | Antacids and antidiarrheals should be taken at least 2 to 3 hours apart from pyrimethamine. | ||||||||
| References | |||||||||||||||||||
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| 1 | Cerner Multum, Inc. "UK Summary of Product Characteristics.". | ||||||||||||||||||
| 2 | Multum Information Services, Inc. Expert Review Panel. | ||||||||||||||||||