Details of Drug-Drug Interaction
| Drug General Information (ID: DDIGZKF9OR) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Drug Name | Sulfasalazine | Drug Info | Phenobarbital | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Antiinflammatory Agents | Anticonvulsants | |||||||
| Structure | |||||||||
| Mechanism of Sulfasalazine-Phenobarbital Interaction (Severity Level: Minor) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Competitive inhibition of bile excretion Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Sulfasalazine | Phenobarbital | |||||||
| Mechanism | Sulfasalazine | Increase biliary excretion of sulfasalazine | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Biliary excretion | ||||||||
| Factor Description | Biliary excretion is an important way for the body to remove certain drugs and drug metabolites. Biliary excretion of drugs may be reduced when two drugs compete for it. | ||||||||
| Mechanism Description |
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