Details of Drug

Details of Drug

 Drug General Information (ID: D1397)
  Drug Name
Ribavirin
  Drug Type Small molecule
  Drug Synonymous
ribavirin; 36791-04-5; Tribavirin; Rebetol; Virazole; Ribavirine; Copegus; Vilona; Ribamide; Ribasphere; Ribamidil; Viramid; Ribamidyl; Ribavirinum; Ribavirina; Rebetron; Varazid; RTCA; Ribavirin Capsules; Ribavirinum [INN-Latin]; Ribavirine [INN-French]; Ribavirina [INN-Spanish]; ICN-1229; Rebretron; Virazid; Ribav; 1-beta-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide; DRG-0028; 1-beta-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide; UNII-49717AWG6K; Ribavirin (Copegus); Copegus; Cotronak; RBV; RTC; Ravanex; Ribacine; Ribovirin; Viramide; Virazide; R 9644; SCH 18908; C-Virin; Copegus (TN); Drug: Ribavirin; KS-1104; R-964; RG-964; Rebetol (TN); Ribasphere (TN); Ribavirin [USAN:INN]; Vilona (TN); Virazole (Ribavirin) Inhalation Solution; Virazole (TN); AA-504/07617051; Ro 20-9963/000; Ro-20-9963; Ribavirin (JAN/USP/INN); 1-beta-D-Ribofuranosyl-1,2,4-triazolo-3-carboxamide; 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide; 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-1,2,4-triazole-3-carboxamide; 1-beta-D-ribofuranosyl-1-H-1,2,4-triazole-3-carboxamide; RBI034 (2-5A antisense compound) + Ribavirin
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  Disease Class 1E50-1E51: Hepatitis virus infection
  Therapeutic Class Antiviral Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C8H12N4O5
  InChI 1S/C8H12N4O5/c9-6(16)7-10-2-12(11-7)8-5(15)4(14)3(1-13)17-8/h2-5,8,13-15H,1H2,(H2,9,16)/t3-,4-,5-,8-/m1/s1
  InChIKey IWUCXVSUMQZMFG-AFCXAGJDSA-N
  Canonical SMILES C1=NC(=NN1C2C(C(C(O2)CO)O)O)C(=O)N
  External Link
Pubchem ID 37542
CAS Number 36791-04-5
CHEBI ID 63580
TTD ID D0H3WI
INTEDE ID DR1413
VARIDT ID DR00176

Drug-Drug Interaction Network
  Sunburst Graph
AM004  Affected intra/extra-hepatic metabolism
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM018  Non-CYP450 enzyme inhibition
BM070  Increased risk of metabolic acidosis
BM085  Antagonize the effect of antithrombotic agents
BM107  Attenuated pharmacological effects (Unspecific)
BM109  Increased risk of other adverse reactions (Unspecific)
  Relation Graph
 Full list of drugs interacting with Ribavirin
      Affected intra/extra-hepatic metabolism
   Non-CYP450 enzyme inhibition Drug Num:  2
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0136
 
Azathioprine
 
C9H7N7O2S
 
2265 
Major    Inter Info   
[3], [1], [4], [5], [6], [7]
D1007
 
Mercaptopurine
 
C5H4N4S
 
667490 
Major    Inter Info   
[3], [1], [4], [5], [6], [7]
      Pharmacodynamic additive effects
   Increased risk of metabolic acidosis Drug Num:  4
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0889
 
Lamivudine
 
C8H11N3O3S
 
60825 
Moderate    Inter Info   
[14], [6], [9]
D0001
 
Abacavir
 
C14H18N6O
 
441300 
Moderate    Inter Info   
[14], [6], [9]
D0566
 
Emtricitabine
 
C8H10FN3O3S
 
60877 
Moderate    Inter Info   
[14], [6], [9]
D1715
 
Zalcitabine
 
C9H13N3O3
 
24066 
Moderate    Inter Info   
[14], [6], [9]
   Increased risk of other adverse reactions (Unspecific) Drug Num:  2
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0178
 
Bexarotene
 
C24H28O2
 
82146 
Major    Inter Info   
[1], [2]
D0483
 
Didanosine
 
C10H12N4O3
 
135398739 
Major    Inter Info   
[6], [8], [9]
      Pharmacodynamic antagonistic effects
   Antagonize the effect of antithrombotic agents Drug Num:  3
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0481
 
Dicoumarol
 
C19H12O6
 
54676038 
Moderate    Inter Info   
[6], [12], [13]
D0087
 
Anisindione
 
C16H12O3
 
2197 
Moderate    Inter Info   
[6], [12], [13]
D1711
 
Warfarin
 
C19H16O4
 
54678486 
Moderate    Inter Info   
[6], [12], [13]
   Attenuated pharmacological effects (Unspecific) Drug Num:  3
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0348
 
Cladribine
 
C10H12ClN5O3
 
20279 
Moderate    Inter Info   
[1], [10], [11]
D1504
 
Stavudine
 
C10H12N2O4
 
18283 
Moderate    Inter Info   
[14], [15], [16], [17], [18], [6], [19], [20], [21], [22]
D1720
 
Zidovudine
 
C10H13N5O4
 
35370 
Moderate    Inter Info   
[1], [16], [21]
References
1 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2 Product Information. Targretin (bexarotene) Ligand Pharmaceuticals, San Diego, CA.
3 Canadian Pharmacists Association.
4 Chaparro M, Trapero-Marugan M, Moreno-Otero R, Gisbert JP "Azathioprine plus ribavirin treatment and pancytopenia." Aliment Pharmacol Ther 30 (2009): 962-3. [PMID: 19807727]
5 Peyrin-Biroulet L, Cadranel JF, Nousbaum JB, et al. "Interaction of ribavirin with azathioprine metabolism potentially induces myelosuppression." Aliment Pharmacol Ther 28 (2008): 984-93. [PMID: 18657132]
6 Product Information. Copegus (ribavirin). Roche Laboratories, Nutley, NJ.
7 Thevenot T, Mathurin P, Moussalli J, Perrin M, Plassart F, Blot C, Opolon P, Poynard T "Effects of cirrhosis, interferon and azathioprine on adverse events in patients with chronic hepatitis C treated with ribavirin." J Viral Hepat 4 (1997): 243-53. [PMID: 9278222]
8 Balzarini J, Lee CK, Herdewijn P, De Clercq E "Mechanism of the potential effect of ribavirin on the activity of 2',3'-dideoxyinosine against human immunodeficiency virus." J Biol Chem 266 (1991): 21509-14.[PMID: 1939181]
9 Product Information. Rebetron (interferon-alfa-2b-ribavirin). Schering Laboratories, Kenilworth, NJ.
10 EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
11 Product Information. Leustatin (cladribine). Ortho Biotech Inc, Raritan, NJ.
12 Product Information. Rebetol (ribavirin). Schering-Plough Corporation, Kenilworth, NJ.
13 Schulman S "Inhibition of warfarin activity by ribavirin." Ann Pharmacother 36 (2002): 72-4
14 Guyader D, Poinsignon Y, Cano Y, Saout L "Fatal lactic acidosis in a HIV-positive patient treated with interferon and ribavirin for chronic hepatitis C." J Hepatol 37 (2002): 289-91. [PMID: 12127440]
15 Hoggard PG, Kewn S, Barry MG, Khoo SH, Back DJ "Effects of drugs on 2',3'-didehydrothymidine phosphorylation in vitro." Antimicrob Agents Chemother 41 (1997): 1231-6. [PMID: 9174176]
16 Hoggard PG, Veal GJ, Wild MJ, Barry MG, Back DJ "Drug interactions with zidovudine phosphorylation in vitro." Antimicrob Agents Chemother 39 (1995): 1376-8. [PMID: 7574535]
17 Lafeuillade A, Hittinger G, Chadapaud S "Increased mitochondrial toxicity with ribavirin in HIV/HCV coinfection." Lancet 357 (2001): 280-1. [PMID: 11214134]
18 Landau A, Batisse D, Piketty C, Jian R, Kazatchkine MD "Lack of interference between ribavirin and nucleosidic analogues in HIV/HCV co-infected individuals undergoing concomitant antiretroviral and anti-HCV combination therapy." AIDS 14 (2000): 1857-8. [PMID: 10985327]
19 Product Information. Retrovir (zidovudine). Glaxo Wellcome, Research Triangle Park, NC.
20 Taburet AM, Singlas E "Drug interactions with antiviral drugs." Clin Pharmacokinet 30 (1996): 385-401. [PMID: 8743337]
21 Vogt MW, Hartshorn KL, Furman PA, et al. "Ribavirin antagonizes the effect of azidothymidine on HIV replication." Science 235 (1987): 1376-9. [PMID: 2435003]
22 Zylberberg H, Benhamou Y, Lagneaux JL, et al "Safety and efficacy of interferon-ribavirin combination therapy in HCV-HIV coinfected subjects: an early report." Gut 47 (2000): 694-7. [PMID: 11034587]