Drug General Information (ID: DDIJOHNMX6)
Drug Name			Ribavirin		Drug Info		Didanosine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiviral Agents				Anti-Hiv Agents
Structure

Mechanism of Ribavirin-Didanosine Interaction (Severity Level: Major)
Increased risk of other adverse reactions (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Ribavirin				Didanosine
Mechanism		Increase the antiretroviral effect and clinical toxicity of didanosine				Didanosine
Key Mechanism Factor 1
		Factor Name		Adverse reactions
		Factor Description		An adverse reaction is an unexpected negative reaction to a medication or treatment that happens even when it's used correctly.
Mechanism Description		Increased risk of adverse reactions by the combination of Didanosine and Ribavirin

Recommended Action
Management		The concomitant use of oral ribavirin and didanosine is considered contraindicated by US authorities.

References
1	Product Information. Copegus (ribavirin). Roche Laboratories, Nutley, NJ.
2	Balzarini J, Lee CK, Herdewijn P, De Clercq E "Mechanism of the potential effect of ribavirin on the activity of 2',3'-dideoxyinosine against human immunodeficiency virus." J Biol Chem 266 (1991): 21509-14.[PMID: 1939181]
3	Product Information. Rebetron (interferon-alfa-2b-ribavirin). Schering Laboratories, Kenilworth, NJ.