Details of Drug

Details of Drug

 Drug General Information (ID: D1362)
  Drug Name
Prucalopride
  Drug Type Small molecule
  Drug Synonymous
Prucalopride; 179474-81-8; UNII-0A09IUW5TP; 4-Amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide; 0A09IUW5TP; C18H26ClN3O3; CHEMBL117287; R-093877; 4-amino-5-chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-carboxamide; R 093877; 4-Amino-5-chloro-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide; 4-Amino-5-chloro-2,3-dihydro-N-(1-(3-methoxypropyl)-4-piperidyl)-7-benzofurancarboxamide; R093877; Motegrity; Prucalopride [USAN:INN:BAN]
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  Disease Class DD91: Irritable bowel syndrome
  Therapeutic Class Serotoninergic Neuroenteric Modulators
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C18H26ClN3O3
  InChI 1S/C18H26ClN3O3/c1-24-9-2-6-22-7-3-12(4-8-22)21-18(23)14-11-15(19)16(20)13-5-10-25-17(13)14/h11-12H,2-10,20H2,1H3,(H,21,23)
  InChIKey ZPMNHBXQOOVQJL-UHFFFAOYSA-N
  Canonical SMILES COCCCN1CCC(CC1)NC(=O)C2=CC(=C(C3=C2OCC3)N)Cl
  External Link
Pubchem ID 3052762
CAS Number 179474-81-8
CHEBI ID 135552
TTD ID D04QSJ
VARIDT ID DR00187

Drug-Drug Interaction Network
  Sunburst Graph
AM001  Affected gastrointestinal absorption
AM002  Affected cellular transport
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM009  Altered absorption (Unspecific)
BM010  Transporter inhibition
BM076  Increased risk of prolong QT interval
BM091  Antagonize the effect of cholinergic agents
BM109  Increased risk of other adverse reactions (Unspecific)
  Relation Graph
 Full list of drugs interacting with Prucalopride
      Affected gastrointestinal absorption
   Altered absorption (Unspecific) Drug Num:  5
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0922
 
Levonorgestrel
 
C21H28O2
 
13109 
Moderate    Inter Info   
[5], [6], [2]
D1011
 
Mestranol
 
C21H26O2
 
6291 
Moderate    Inter Info   
[5], [6], [2]
D1154
 
Norethisterone
 
C20H26O2
 
6230 
Moderate    Inter Info   
[5], [6], [2]
D0485
 
Dienogest
 
C20H25NO2
 
68861 
Moderate    Inter Info   
[5], [6], [2]
D1157
 
Norgestrel
 
C21H28O2
 
13109 
Moderate    Inter Info   
[5], [6], [2]
      Affected cellular transport
   Transporter inhibition Drug Num:  3
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0590
 
Erdafitinib
 
C25H30N6O2
 
67462786 
Moderate    Inter Info   
[7]
D0720
 
Gilteritinib
 
C29H44N8O3
 
49803313 
Moderate    Inter Info   
[5], [6], [8]
D0897
 
Lasmiditan
 
C19H18F3N3O2
 
11610526 
Moderate    Inter Info   
[10]
      Pharmacodynamic additive effects
   Increased risk of prolong QT interval Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0937
 
Lisdexamfetamine
 
C15H25N3O
 
11597698 
Moderate    Inter Info   
[6]
   Increased risk of other adverse reactions (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0789
 
Idelalisib
 
C22H18FN7O
 
11625818 
Moderate    Inter Info   
[9]
      Pharmacodynamic antagonistic effects
   Antagonize the effect of cholinergic agents Drug Num:  31
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0123
 
Atropine
 
C17H23NO3
 
174174 
Moderate    Inter Info   
[1], [2]
D0160
 
Benzatropine
 
C21H25NO
 
1201549 
Moderate    Inter Info   
[3], [2], [4]
D0183
 
Biperiden
 
C21H29NO
 
2381 
Moderate    Inter Info   
[1], [2]
D0353
 
Clidinium
 
C22H26NO3+
 
2784 
Moderate    Inter Info   
[1], [2]
D0397
 
Cyclizine
 
C18H22N2
 
6726 
Moderate    Inter Info   
[1], [2]
D0424
 
Darifenacin
 
C28H30N2O2
 
444031 
Moderate    Inter Info   
[1], [2]
D0482
 
Dicyclomine
 
C19H35NO2
 
3042 
Moderate    Inter Info   
[1], [2]
D0498
 
Dimenhydrinate
 
C24H28ClN5O3
 
10660 
Moderate    Inter Info   
[1], [2]
D0502
 
Diphenhydramine
 
C17H21NO
 
3100 
Moderate    Inter Info   
[1], [2]
D0662
 
Flavoxate
 
C24H25NO4
 
3354 
Moderate    Inter Info   
[1], [2]
D0733
 
Glycopyrronium
 
C19H28NO3+
 
3494 
Moderate    Inter Info   
[3], [2], [4]
D0782
 
Hyoscyamine
 
C17H23NO3
 
154417 
Moderate    Inter Info   
[1], [2]
D0842
 
Ipratropium
 
C20H30NO3+
 
657309 
Moderate    Inter Info   
[1], [2]
D0987
 
Meclizine
 
C25H27ClN2
 
4034 
Moderate    Inter Info   
[1], [2]
D1000
 
Mepenzolate
 
C21H26NO3+
 
4057 
Moderate    Inter Info   
[1], [2]
D1202
 
Oxybutynin
 
C22H31NO3
 
4634 
Moderate    Inter Info   
[1], [2]
D1347
 
Procyclidine
 
C19H29NO
 
4919 
Moderate    Inter Info   
[1], [2]
D1354
 
Propantheline
 
C23H30NO3+
 
4934 
Moderate    Inter Info   
[1], [2]
D0019
 
Aclidinium
 
C26H30NO4S2+
 
11434515 
Moderate    Inter Info   
[1], [2]
D0154
 
Belladonna
 
C34H42N2O4
 
265028 
Moderate    Inter Info   
[1], [2]
D0655
 
Fesoterodine
 
C26H37NO3
 
6918558 
Moderate    Inter Info   
[1], [2]
D1031
 
Methscopolamine
 
C18H24NO4+
 
71183 
Moderate    Inter Info   
[1], [2]
D1396
 
Revefenacin
 
C35H43N5O4
 
11753673 
Moderate    Inter Info   
[1], [2]
D1665
 
Umeclidinium
 
C29H34NO2+
 
11519070 
Moderate    Inter Info   
[1], [2]
D1450
 
Scopolamine
 
C17H21NO4
 
3000322 
Moderate    Inter Info   
[1], [2]
D1491
 
Solifenacin
 
C23H26N2O2
 
154059 
Moderate    Inter Info   
[1], [2]
D1590
 
Tiotropium
 
C19H22NO4S2+
 
5487427 
Moderate    Inter Info   
[1], [2]
D1607
 
Tolterodine
 
C22H31NO
 
443879 
Moderate    Inter Info   
[1], [2]
D1641
 
Trihexyphenidyl
 
C20H31NO
 
5572 
Moderate    Inter Info   
[1], [2]
D1644
 
Trimethobenzamide
 
C21H28N2O5
 
5577 
Moderate    Inter Info   
[1], [2]
D1656
 
Trospium
 
C25H30NO3+
 
5284632 
Moderate    Inter Info   
[1], [2]
References
1 EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
2 Product Information. Resotran (prucalopride). Janssen Pharmaceuticals, Titusville, NJ.
3 EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
4 Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
5 Cerner Multum, Inc. "Australian Product Information.".
6 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
7 Product Information. Balversa (erdafitinib). Janssen Products, LP, Horsham, PA.
8 Product Information. Xospata (gilteritinib). Astellas Pharma US, Inc, Deerfield, IL.
9 Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
10 Product Information. Reyvow (lasmiditan). Lilly, Eli and Company, Indianapolis, IN.