Drug General Information (ID: DDIYV3X54F)
Drug Name			Lisdexamfetamine		Drug Info		Prucalopride		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Cns Stimulants				Serotoninergic Neuroenteric Modulators
Structure

Mechanism of Lisdexamfetamine-Prucalopride Interaction (Severity Level: Moderate)
Increased risk of prolong QT interval Click to Show/Hide Mechanism Graph
Drug Name		Lisdexamfetamine				Prucalopride
Mechanism		Prolong QT interval				Prolong QT interval
Key Mechanism Factor 1
		Factor Name		QT interval
		Factor Description		Long QT syndrome is a heart signaling disorder that can cause a fast, chaotic heartbeat (arrhythmia). Many people may not exhibit symptoms, and usually the condition is detected during routine medical tests. In others, the most common symptoms include: sudden fainting, palpitations, dizziness, seizures, sudden death.
Mechanism Description		Increased risk of prolong QT interval by the combination of Lisdexamfetamine and Prucalopride

Recommended Action
Management		Caution is recommended whenever lisdexamfetamine is used concomitantly with other agents known to cause QT prolongation. Patients should be advised to seek prompt medical attention if they experience symptoms that could indicate the occurrence of torsade de pointes such as dizziness, lightheadedness, fainting, palpitation, irregular heart rhythm, shortness of breath, or syncope.

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".