Drug General Information (ID: DDIS0EB7Z2)
Drug Name			Prucalopride		Drug Info		Dienogest		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Serotoninergic Neuroenteric Modulators				Contraceptives
Structure

Mechanism of Prucalopride-Dienogest Interaction (Severity Level: Moderate)
Altered absorption (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Prucalopride				Dienogest
Mechanism		Vomiting/diarrhea-causing agent				Absorption decreased by vomiting/diarrhea-causing agents
Key Mechanism Factor 1
		Factor Name		Pharmacokinetic
		Factor Description		Alters the absorption of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Altered absorption of Dienogest caused by Prucalopride

Recommended Action
Management		In patients who develop severe diarrhea during treatment with prucalopride, the use of an additional contraceptive method is recommended to prevent possible failure of oral contraception. If severe or persistent diarrhea occurs, patients should be advised to stop taking prucalopride and consult their physician.

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	Product Information. Resotran (prucalopride). Janssen Pharmaceuticals, Titusville, NJ.