Details of Drug

Drug General Information (ID: D1329)
Drug Name	Pravastatin
Drug Type	Small molecule
Drug Synonymous	Eptastatin; Oliprevin; Pravastatina; Pravastatine; Pravastatinum; Pravator; Vasten; Pravastatin Sodium Salt; Pravastatina [Spanish]; Pravastatine [French]; Pravastatinum [Latin]; KS-5015; Pravachol (TN); Pravastatin (INN); Pravastatin [INN:BAN]; Pravastatin tert-Octylamine Salt; Pravator (TN); RMS-431; Selektine (TN); SQ-31,000; (3R,5R)-3,5-dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]heptanoic acid; (3R,5R)-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-[(2S)-2-methylbutanoyl]oxy-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid; 1,2,6,7,8,8a-hexahydro-beta,delta,6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-, (1S-(1alpha(betaS,deltaS),2alpha,6alpha,8beta(R*),8aalpha))-1-Naphthaleneheptanoic acid Click to Show/Hide
Disease Class	5C80: Hyper-lipoproteinaemia
Therapeutic Class	Statins/Antihyperlipidemic Agents
Structure
Structure	3D Structure		2D Structure
Formula	C23H36O7
InChI	1S/C23H36O7/c1-4-13(2)23(29)30-20-11-17(25)9-15-6-5-14(3)19(22(15)20)8-7-16(24)10-18(26)12-21(27)28/h5-6,9,13-14,16-20,22,24-26H,4,7-8,10-12H2,1-3H3,(H,27,28)/t13-,14-,16+,17+,18+,19-,20-,22-/m0/s1
InChIKey	TUZYXOIXSAXUGO-PZAWKZKUSA-N
Canonical SMILES	CCC(C)C(=O)OC1CC(C=C2C1C(C(C=C2)C)CCC(CC(CC(=O)O)O)O)O
External Link
	Pubchem ID	54687
	CAS Number	81093-37-0
	CHEBI ID	63618
	TTD ID	D02RQU
	INTEDE ID	DR1327
	VARIDT ID	DR00045

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM003 Complex formation BM009 Altered absorption (Unspecific) BM010 Transporter inhibition BM011 Transporter induction BM022 CYP450 enzyme induction BM023 UGT induction BM050 Increased risk of bleeding BM055 Increased risk of hepatotoxicity BM074 Increased risk of peripheral neuropathy BM075 Increased risk of photosensitivity reactions BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Pravastatin
Affected gastrointestinal absorption
	Complex formation					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0329		Cholestyramine	C27H47ClN2	137699107	Moderate		Inter Info	[72]
D0382		Colestipol	C11H28ClN5O	62816	Moderate		Inter Info	[72]
	Altered absorption (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1233		Pectin	C6H10O7	441476	Moderate		Inter Info	[82]
Affected cellular transport
	Transporter inhibition					Drug Num: 21
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0402		Cyclosporine	C62H111N11O12	5284373	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18]
D0155		Bempedoic acid	C19H36O5	10472693	Major		Inter Info	[19], [20], [21]
D0726		Glecaprevir	C38H46F4N6O9S	66828839	Major		Inter Info	[30]
D1227		Paritaprevir	C40H43N7O7S	45110509	Major		Inter Info	[38], [39], [40]
D1710		Voxilaprevir	C40H52F4N6O9S	89921642	Major		Inter Info	[42]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[73], [14], [74]
D0375		Cobicistat	C40H53N7O5S2	25151504	Moderate		Inter Info	[3], [19], [76], [77], [78], [79]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[3], [19], [80]
D0408		Daclatasvir	C40H50N8O6	25154714	Moderate		Inter Info	[19], [81], [82]
D0425		Darolutamide	C19H19ClN6O2	67171867	Moderate		Inter Info	[19], [83]
D0558		Elexacaftor	C26H34F3N7O4S	134587348	Moderate		Inter Info	[86], [87], [88]
D0561		Eltrombopag	C25H22N4O4	135449332	Moderate		Inter Info	[89], [3], [90]
D0568		Enasidenib	C19H17F6N7O	89683805	Moderate		Inter Info	[3], [91]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Moderate		Inter Info	[19], [92]
D0577		Entrectinib	C31H34F2N6O2	25141092	Moderate		Inter Info	[3], [19], [93]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[73], [14], [74]
D0700		Fostemsavir	C25H26N7O8P	11319217	Moderate		Inter Info	[97]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[99]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[19]
D1436		Sacubitril	C24H29NO5	9811834	Moderate		Inter Info	[31], [19], [82]
D1471		Simeprevir	C38H47N5O7S2	24873435	Moderate		Inter Info	[112]
	Transporter induction					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0095		Apalutamide	C21H15F4N5O2S	24872560	Moderate		Inter Info	[19], [64]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme induction					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[84], [85]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[84], [85]
	UGT induction					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[38], [39], [111]
Pharmacodynamic additive effects
	Increased risk of bleeding					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0087		Anisindione	C16H12O3	2197	Minor		Inter Info	[120], [121], [14]
D0481		Dicoumarol	C19H12O6	54676038	Minor		Inter Info	[120], [121], [14]
D1711		Warfarin	C19H16O4	54678486	Minor		Inter Info	[120], [121], [14]
	Increased risk of hepatotoxicity					Drug Num: 25
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[31], [32], [33]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[36]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[37]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[41]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[31], [32], [33]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[46], [47], [48], [3], [19], [49], [50], [51], [52], [53], [54], [55], [56]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[60], [61], [62], [63]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[60], [61], [62], [63]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[46], [47], [48], [3], [19], [49], [50], [51], [52], [53], [54], [55], [56]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[46], [47], [48], [3], [19], [49], [50], [51], [52], [53], [54], [55], [56]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[65]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[69], [70]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[46], [47], [48], [3], [19], [49], [50], [51], [52], [53], [54], [55], [56]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[19], [71]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[75]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[3], [19], [94]
D0617		Ethanol	C2H6O	702	Moderate		Inter Info	[95], [96], [14]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[98]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[19], [100]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[101]
D1232		Pazopanib	C21H23N7O2S	10113978	Moderate		Inter Info	[3], [105], [82]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[60], [61], [62], [63]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[3], [19], [108], [109], [110]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[116], [117]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[19], [118]
	Increased risk of peripheral neuropathy					Drug Num: 76
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Moderate		Inter Info	[43], [44], [45]
D0614		Etanercept	NA	NA	Moderate		Inter Info	[43], [44], [45]
D0802		Infliximab	NA	NA	Moderate		Inter Info	[43], [44], [45]
D0821		Interferon alfa-2a, Recombinant	NA	NA	Moderate		Inter Info	[43], [44], [45]
D0822		Interferon alfa-2b	C16H17Cl3I2N3NaO5S	71306834	Moderate		Inter Info	[43], [44], [45]
D0824		Interferon alfa-n1	NA	NA	Moderate		Inter Info	[43], [44], [45]
D0823		Interferon alfacon-1	NA	NA	Moderate		Inter Info	[43], [44], [45]
D1237		Peginterferon alfa-2a	NA	NA	Moderate		Inter Info	[43], [44], [45]
D1238		Peginterferon alfa-2b	NA	NA	Moderate		Inter Info	[43], [44], [45]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[43], [44], [45]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[43], [44], [45]
D0126		Auranofin	C20H34AuO9PS	24199313	Moderate		Inter Info	[43], [44], [45]
D0127		Aurothioglucose	C6H11AuO5S	454937	Moderate		Inter Info	[43], [44], [45]
D0162		Benznidazole	C12H12N4O3	31593	Moderate		Inter Info	[43], [44], [45]
D0193		Bortezomib	C19H25BN4O4	387447	Moderate		Inter Info	[66], [67], [68]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[43], [44], [45]
D0260		Carboplatin	C6H12N2O4Pt	426756	Moderate		Inter Info	[43], [44], [45]
D0261		Carfilzomib	C40H57N5O7	11556711	Moderate		Inter Info	[43], [44], [45]
D0303		Cerivastatin	C26H34FNO5	446156	Moderate		Inter Info	[43], [44], [45]
D0304		Certolizumab pegol	NA	NA	Moderate		Inter Info	[43], [44], [45]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[43], [44], [45]
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[43], [44], [45]
D0344		Cisplatin	Cl2H6N2Pt	5702198	Moderate		Inter Info	[43], [44], [45]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[43], [44], [45]
D0419		Dapsone	C12H12N2O2S	2955	Moderate		Inter Info	[43], [44], [45]
D0483		Didanosine	C10H12N4O3	135398739	Moderate		Inter Info	[43], [44], [45]
D0496		Diiodohydroxyquinoline	C9H5I2NO	3728	Moderate		Inter Info	[43], [44], [45]
D0501		Dinutuximab	NA	NA	Moderate		Inter Info	[43], [44], [45]
D0509		Disulfiram	C10H20N2S4	3117	Moderate		Inter Info	[43], [44], [45]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[43], [44], [45]
D0560		Elotuzumab	NA	NA	Moderate		Inter Info	[43], [44], [45]
D0571		Enfortumab vedotin	NA	NA	Moderate		Inter Info	[43], [44], [45]
D0594		Eribulin	C40H59NO11	11354606	Moderate		Inter Info	[43], [44], [45]
D0616		Ethambutol	C10H24N2O2	14052	Moderate		Inter Info	[43], [44], [45]
D1731		Ethionamide	C8H10N2S	2761171	Moderate		Inter Info	[43], [44], [45]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[43], [44], [45]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[43], [44], [45]
D0669		Fludarabine	C10H12FN5O4	657237	Moderate		Inter Info	[43], [44], [45]
D0686		Fluvastatin	C24H26FNO4	446155	Moderate		Inter Info	[43], [44], [45]
D0736		Golimumab	NA	NA	Moderate		Inter Info	[43], [44], [45]
D0770		Hydralazine	C8H8N4	3637	Moderate		Inter Info	[43], [44], [45]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Moderate		Inter Info	[43], [44], [45]
D0841		Ipilimumab	NA	NA	Moderate		Inter Info	[43], [44], [45]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[43], [44], [45]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[43], [44], [45]
D0874		Ixazomib	C14H19BCl2N2O4	25183872	Moderate		Inter Info	[43], [44], [45]
D0918		Levodopa	C9H11NO4	6047	Moderate		Inter Info	[43], [44], [45]
D0933		Linezolid	C16H20FN3O4	441401	Moderate		Inter Info	[43], [44], [45]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[43], [44], [45]
D1051		Metronidazole	C6H9N3O3	4173	Moderate		Inter Info	[43], [44], [45]
D1113		Naxitamab	NA	NA	Moderate		Inter Info	[43], [44], [45]
D1118		Nelarabine	C11H15N5O5	3011155	Moderate		Inter Info	[43], [44], [45]
D1145		Nitrofurantoin	C8H6N4O5	6604200	Moderate		Inter Info	[43], [44], [45]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[43], [44], [45]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[43], [44], [45]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[43], [44], [45]
D1301		Pitavastatin	C25H24FNO4	5282452	Moderate		Inter Info	[43], [44], [45]
D1306		Polatuzumab vedotin	NA	NA	Moderate		Inter Info	[43], [44], [45]
D1312		Pomalidomide	C13H11N3O4	134780	Moderate		Inter Info	[43], [44], [45]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[43], [44], [45]
D1430		Rosuvastatin	C22H28FN3O6S	446157	Moderate		Inter Info	[43], [44], [45]
D1452		Secnidazole	C7H11N3O3	71815	Moderate		Inter Info	[43], [44], [45]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[43], [44], [45]
D1479		Sodium aurothiomalate	C4H3AuNa2O4S	22318	Moderate		Inter Info	[43], [44], [45]
D1504		Stavudine	C10H12N2O4	18283	Moderate		Inter Info	[43], [44], [45]
D1551		Teniposide	C32H32O13S	452548	Moderate		Inter Info	[43], [44], [45]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[66], [3], [19], [115]
D1587		Tinidazole	C8H13N3O4S	5479	Moderate		Inter Info	[43], [44], [45]
D1599		Tocilizumab	NA	NA	Moderate		Inter Info	[43], [44], [45]
D1623		Trastuzumab emtansine	NA	NA	Moderate		Inter Info	[43], [44], [45]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[43], [44], [45]
D1698		Vincristine	C46H56N4O10	5978	Moderate		Inter Info	[43], [44], [45]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Moderate		Inter Info	[43], [44], [45]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[43], [44], [45]
D1714		Zafirlukast	C31H33N3O6S	5717	Moderate		Inter Info	[43], [44], [45]
D1715		Zalcitabine	C9H13N3O3	24066	Moderate		Inter Info	[66], [119]
	Increased risk of photosensitivity reactions					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1314		Porfimer sodium	C68H74N8O11	135577896	Moderate		Inter Info	[106], [19], [107]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 10
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0360		Clofibrate	C12H15ClO3	2796	Major		Inter Info	[22], [23], [24]
D0380		Colchicine	C22H25NO6	6167	Major		Inter Info	[25], [26], [27]
D0642		Fenofibrate	C20H21ClO4	3339	Major		Inter Info	[22], [23], [24]
D0643		Fenofibric acid	C17H15ClO4	64929	Major		Inter Info	[28], [29]
D0715		Gemfibrozil	C15H22O3	3463	Major		Inter Info	[22], [23], [24]
D0902		Lenalidomide	C13H13N3O3	216326	Major		Inter Info	[19], [34], [35]
D0421		Daptomycin	C72H101N17O26	16134395	Moderate		Inter Info	[57], [58], [59]
D1129		Niacin	C6H5NO2	938	Moderate		Inter Info	[102], [103], [104]
D1543		Telbivudine	C10H14N2O5	159269	Moderate		Inter Info	[113], [114]
D1720		Zidovudine	C10H13N5O4	35370	Moderate		Inter Info	[113], [114]

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