Drug General Information (ID: DDICAW7QRM)
Drug Name			Pravastatin		Drug Info		Ethanol		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Statins/Antihyperlipidemic Agents				Analgesics
Structure

Mechanism of Pravastatin-Ethanol Interaction (Severity Level: Moderate)
Increased risk of hepatotoxicity Click to Show/Hide Mechanism Graph
Drug Name		Pravastatin				Ethanol
Mechanism		Hepatotoxicity				Hepatotoxicity
Key Mechanism Factor 1
		Factor Name		Hepatotoxicity
		Factor Description		Combination of drugs that can induce hepatotoxicity may increase the risk of liver injury. Symptoms vary depending on the level of exposure and the total extent of liver damage, and may cause few symptoms if the damage is mild, and eventually lead to liver failure in patients with severe damage.
Mechanism Description		Increased risk of hepatotoxicity by the combination of Pravastatin and Ethanol

Recommended Action
Management		Patients should be counseled to avoid substantial quantities of alcohol in combination with statin medications and clinicians should be aware of the increased risk for hepatotoxicity in these patients.

References
1	Product Information. Crestor (rosuvastatin). AstraZeneca Pharma Inc, Mississauga, ON.
2	Product Information. Lipitor (atorvastatin). Parke-Davis, Morris Plains, NJ.
3	Product Information. Pravachol (pravastatin). Bristol-Myers Squibb, Princeton, NJ.