Details of Drug

Drug General Information (ID: D1145)
Drug Name	Nitrofurantoin
Drug Type	Small molecule
Drug Synonymous	Alfuran; Benkfuran; Berkfuran; Berkfurin; Ceduran; Chemiofuran; Cistofuran; Cyantin; Cystit; Dantafur; Furabid; Furachel; Furadantin; Furadantine; Furadantoin; Furadoine; Furadonin; Furadonine; Furadoninum; Furadontin; Furalan; Furaloid; Furantoin; Furatoin; Furedan; Furina; Furobactina; Furodantin; Furophen; Gerofuran; Ituran; Macpac; Macrobid; Macrodantin; Macrodantina; Macrofuran; Macrofurin; NITROFURANTION; Nierofu; Nifurantin; Nifuretten; Nitoin; Nitrex; Nitrofuradantin; Nitrofurantoina; Nitrofurantoine; Nitrofurantoinum; Novofuran; Orafuran; Parfuran; Phenurin; PiyEloseptyl; Siraliden; Trantoin; Uerineks; Urantoin; Urizept; Urodil; Urodin; Urofuran; Urofurin; Urolisa; Urolong; Welfurin; Zoofurin; Fua Med; Furadantin Retard; Furadantina MC; Furadantine mc; Furophen T; NITROFURANTOIN MACROCRYSTALLINE; Nitrofurantoina [DCIT]; Fua-med; Fur-ren; Furadantin (TN); Furadantine-MC; Macrobid (TN); Macrodantin (TN); N-Toin; ND-3320; ND-7248; NITROFURANTOIN, MACROCRYSTALLINE; Nitro Macro (TN); Nitrofur-C; Nitrofurantoine [INN-French]; Nitrofurantoinum [INN-Latin]; Ro-Antoin; Urantoin (TN); Uro-Selz; Uro-Tablinen; Uro-tablineu; Usaf ea-2; Nitrofurantoin (JAN/USP/INN); Nitrofurantoin [USAN:INN:BAN:JAN]; N-(5-Nitrofurfurylidene)-1-aminohydantoin; N-(5-Nitro-2-furfurylidene)-1-aminohydantoin; N-(5-Nitro-2-furfurylideno)-1-aminohydantoina; N-(5-Nitro-2-furfurylideno)-1-aminohydantoina [Polish]; N-(5-nitro-2-furfurylidene)-1-aminohyda ntoin; 1-(((5-nitro-2-furanyl)methylene)amino)-2,4-imidazolidinedione; 1-((5-Nitrofurfurylidene)amino)hydantoin; 1-(5-Nitro-2-furfurylidenamino)hydantoin; 1-(5-Nitro-2-furfurylideneamino)hydantoin; 1-[(5-:nitrofurfurylidene)amino]hydantoin; 1-[(5-Nitrofurfurylidene)amino]hydantoin; 1-[(E)-(5-nitrofuran-2-yl)methylideneamino]imidazolidine-2,4-dione; 1-[[(5-Nitro-2-furanyl)methylene]amino]-2,4-imidazolidinedione; 1-{[(1E)-(5-nitro-2-furyl)methylene]amino}imidazolidine-2,4-dione; 1-{[(1E)-(5-nitrofuran-2-yl)methylidene]amino}imidazolidine-2,4-dione; 5-Nitrofurantoin Click to Show/Hide
Disease Class	GC08: Urinary tract infection
Therapeutic Class	Antiinfective Agents
Structure
Structure	3D Structure		2D Structure
Formula	C8H6N4O5
InChI	1S/C8H6N4O5/c13-6-4-11(8(14)10-6)9-3-5-1-2-7(17-5)12(15)16/h1-3H,4H2,(H,10,13,14)/b9-3+
InChIKey	NXFQHRVNIOXGAQ-YCRREMRBSA-N
Canonical SMILES	C1C(=O)NC(=O)N1N=CC2=CC=C(O2)[N+](=O)[O-]
External Link
	Pubchem ID	6604200
	CAS Number	67-20-9
	CHEBI ID	71415
	TTD ID	D0R0BX
	INTEDE ID	DR1169
	VARIDT ID	DR00886

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM001 Altered gastrointestinal dynamics BM002 Altered intestinal flora BM003 Complex formation BM014 Interference of cell/tissue uptake BM022 CYP450 enzyme induction BM055 Increased risk of hepatotoxicity BM071 Increased risk of methemoglobinemia BM074 Increased risk of peripheral neuropathy BM100 Antagonize the effect of vaccine/toxoid BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Nitrofurantoin
Affected gastrointestinal absorption
	Altered gastrointestinal dynamics					Drug Num: 20
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0123		Atropine	C17H23NO3	174174	Minor		Inter Info	[75], [76]
D0160		Benzatropine	C21H25NO	1201549	Minor		Inter Info	[75], [76]
D0424		Darifenacin	C28H30N2O2	444031	Minor		Inter Info	[75], [76]
D0782		Hyoscyamine	C17H23NO3	154417	Minor		Inter Info	[75], [76]
D0154		Belladonna	C34H42N2O4	265028	Minor		Inter Info	[75], [76]
D0183		Biperiden	C21H29NO	2381	Minor		Inter Info	[75], [76]
D0353		Clidinium	C22H26NO3+	2784	Minor		Inter Info	[75], [76]
D0482		Dicyclomine	C19H35NO2	3042	Minor		Inter Info	[75], [76]
D0662		Flavoxate	C24H25NO4	3354	Minor		Inter Info	[75], [76]
D0733		Glycopyrronium	C19H28NO3+	3494	Minor		Inter Info	[75], [76]
D1000		Mepenzolate	C21H26NO3+	4057	Minor		Inter Info	[75], [76]
D1031		Methscopolamine	C18H24NO4+	71183	Minor		Inter Info	[75], [76]
D1202		Oxybutynin	C22H31NO3	4634	Minor		Inter Info	[75], [76]
D1354		Propantheline	C23H30NO3+	4934	Minor		Inter Info	[75], [76]
D1450		Scopolamine	C17H21NO4	3000322	Minor		Inter Info	[75], [76]
D1491		Solifenacin	C23H26N2O2	154059	Minor		Inter Info	[75], [76]
D1607		Tolterodine	C22H31NO	443879	Minor		Inter Info	[75], [76]
D1347		Procyclidine	C19H29NO	4919	Minor		Inter Info	[75], [76]
D1641		Trihexyphenidyl	C20H31NO	5572	Minor		Inter Info	[75], [76]
D1656		Trospium	C25H30NO3+	5284632	Minor		Inter Info	[75], [76]
	Altered intestinal flora					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1094		Mycophenolate mofetil	C23H31NO7	5281078	Moderate		Inter Info	[49], [50]
	Complex formation					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0967		Magaldrate	AlHMgO5S+2	3086011	Minor		Inter Info	[77]
D0968		Magnesium carbonate	CMgO3	11029	Minor		Inter Info	[77]
D0973		Magnesium hydroxide	H2MgO2	14791	Minor		Inter Info	[77]
D0974		Magnesium oxide	MgO	14792	Minor		Inter Info	[77]
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1817		Indium In-111 oxyquinoline	C27H18InN3O3	16685037	Moderate		Inter Info	[57]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme induction					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1003		Mephenytoin	C12H14N2O2	4060	Moderate		Inter Info	[47]
D0621		Ethotoin	C11H12N2O2	3292	Moderate		Inter Info	[47]
Pharmacodynamic additive effects
	Increased risk of hepatotoxicity					Drug Num: 24
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[1], [2], [3]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[4]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[5]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[9]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[1], [2], [3]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[23], [24], [25], [11], [12], [26], [27], [28], [29], [30], [31], [32], [33]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[38]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[40], [41]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[11], [12], [42]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[43], [44], [45], [46]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[43], [44], [45], [46]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[12], [48]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[23], [24], [25], [11], [12], [26], [27], [28], [29], [30], [31], [32], [33]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[52]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[53], [54]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[23], [24], [25], [11], [12], [26], [27], [28], [29], [30], [31], [32], [33]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[12], [55]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[56]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[61]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[43], [44], [45], [46]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[11], [12], [68], [69], [70]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[12], [72]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[23], [24], [25], [11], [12], [26], [27], [28], [29], [30], [31], [32], [33]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[73], [74]
	Increased risk of methemoglobinemia					Drug Num: 13
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1148		Nitrous acid	HNO2	24529	Major		Inter Info	[6], [7], [8]
D1337		Prilocaine	C13H20N2O	4906	Major		Inter Info	[10], [11], [12], [13], [14], [15], [16]
D1338		Prilocaine (topical)	C13H20N2O	4906	Major		Inter Info	[1], [11], [16]
D0339		Cinchocaine (topical)	C20H29N3O2	3025	Moderate		Inter Info	[12], [13], [37]
D0420		Dapsone (topical)	C12H12N2O2S	2955	Moderate		Inter Info	[11], [39]
D1835		Lidocaine (ophthalmic)	C14H22N2O	3676	Moderate		Inter Info	[12], [13], [37]
D0928		Lidocaine (topical)	C14H22N2O	3676	Moderate		Inter Info	[12], [13], [37]
D0163		Benzocaine (topical)	C9H11NO2	2337	Moderate		Inter Info	[12], [13], [37]
D0377		Cocaine (nasal)	C17H21NO4	446220	Moderate		Inter Info	[12], [13], [37]
D0378		Cocaine (topical)	C17H21NO4	446220	Moderate		Inter Info	[12], [13], [37]
D1870		Proparacaine (ophthalmic)	C16H26N2O3	4935	Moderate		Inter Info	[12], [13], [37]
D1904		Tetracaine (ophthalmic)	C15H24N2O2	5411	Moderate		Inter Info	[12], [13], [37]
D1562		Tetracaine (topical)	C15H24N2O2	5411	Moderate		Inter Info	[12], [13], [37]
	Increased risk of peripheral neuropathy					Drug Num: 70
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Moderate		Inter Info	[20], [21], [22]
D0193		Bortezomib	C19H25BN4O4	387447	Moderate		Inter Info	[34], [35], [36]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[20], [21], [22]
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[20], [21], [22]
D0419		Dapsone	C12H12N2O2S	2955	Moderate		Inter Info	[20], [21], [22]
D0614		Etanercept	NA	NA	Moderate		Inter Info	[20], [21], [22]
D0616		Ethambutol	C10H24N2O2	14052	Moderate		Inter Info	[20], [21], [22]
D1731		Ethionamide	C8H10N2S	2761171	Moderate		Inter Info	[20], [21], [22]
D0802		Infliximab	NA	NA	Moderate		Inter Info	[20], [21], [22]
D0821		Interferon alfa-2a, Recombinant	NA	NA	Moderate		Inter Info	[20], [21], [22]
D0822		Interferon alfa-2b	C16H17Cl3I2N3NaO5S	71306834	Moderate		Inter Info	[20], [21], [22]
D0824		Interferon alfa-n1	NA	NA	Moderate		Inter Info	[20], [21], [22]
D0823		Interferon alfacon-1	NA	NA	Moderate		Inter Info	[20], [21], [22]
D0933		Linezolid	C16H20FN3O4	441401	Moderate		Inter Info	[20], [21], [22]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[20], [21], [22]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[20], [21], [22]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[20], [21], [22]
D0126		Auranofin	C20H34AuO9PS	24199313	Moderate		Inter Info	[20], [21], [22]
D0127		Aurothioglucose	C6H11AuO5S	454937	Moderate		Inter Info	[20], [21], [22]
D0162		Benznidazole	C12H12N4O3	31593	Moderate		Inter Info	[20], [21], [22]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[20], [21], [22]
D0260		Carboplatin	C6H12N2O4Pt	426756	Moderate		Inter Info	[20], [21], [22]
D0261		Carfilzomib	C40H57N5O7	11556711	Moderate		Inter Info	[20], [21], [22]
D0304		Certolizumab pegol	NA	NA	Moderate		Inter Info	[20], [21], [22]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[20], [21], [22]
D0483		Didanosine	C10H12N4O3	135398739	Moderate		Inter Info	[20], [21], [22]
D0496		Diiodohydroxyquinoline	C9H5I2NO	3728	Moderate		Inter Info	[20], [21], [22]
D0501		Dinutuximab	NA	NA	Moderate		Inter Info	[20], [21], [22]
D0509		Disulfiram	C10H20N2S4	3117	Moderate		Inter Info	[20], [21], [22]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[20], [21], [22]
D0560		Elotuzumab	NA	NA	Moderate		Inter Info	[20], [21], [22]
D0571		Enfortumab vedotin	NA	NA	Moderate		Inter Info	[20], [21], [22]
D0594		Eribulin	C40H59NO11	11354606	Moderate		Inter Info	[20], [21], [22]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[20], [21], [22]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[20], [21], [22]
D0669		Fludarabine	C10H12FN5O4	657237	Moderate		Inter Info	[20], [21], [22]
D0686		Fluvastatin	C24H26FNO4	446155	Moderate		Inter Info	[20], [21], [22]
D0736		Golimumab	NA	NA	Moderate		Inter Info	[20], [21], [22]
D0770		Hydralazine	C8H8N4	3637	Moderate		Inter Info	[20], [21], [22]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Moderate		Inter Info	[20], [21], [22]
D0841		Ipilimumab	NA	NA	Moderate		Inter Info	[20], [21], [22]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[20], [21], [22]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[20], [21], [22]
D0874		Ixazomib	C14H19BCl2N2O4	25183872	Moderate		Inter Info	[20], [21], [22]
D0918		Levodopa	C9H11NO4	6047	Moderate		Inter Info	[20], [21], [22]
D1113		Naxitamab	NA	NA	Moderate		Inter Info	[20], [21], [22]
D1118		Nelarabine	C11H15N5O5	3011155	Moderate		Inter Info	[20], [21], [22]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[20], [21], [22]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[20], [21], [22]
D1301		Pitavastatin	C25H24FNO4	5282452	Moderate		Inter Info	[20], [21], [22]
D1306		Polatuzumab vedotin	NA	NA	Moderate		Inter Info	[20], [21], [22]
D1312		Pomalidomide	C13H11N3O4	134780	Moderate		Inter Info	[20], [21], [22]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[20], [21], [22]
D1452		Secnidazole	C7H11N3O3	71815	Moderate		Inter Info	[20], [21], [22]
D1479		Sodium aurothiomalate	C4H3AuNa2O4S	22318	Moderate		Inter Info	[20], [21], [22]
D1543		Telbivudine	C10H14N2O5	159269	Moderate		Inter Info	[20], [21], [22]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[34], [11], [12], [71]
D1587		Tinidazole	C8H13N3O4S	5479	Moderate		Inter Info	[20], [21], [22]
D1599		Tocilizumab	NA	NA	Moderate		Inter Info	[20], [21], [22]
D1623		Trastuzumab emtansine	NA	NA	Moderate		Inter Info	[20], [21], [22]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[20], [21], [22]
D1237		Peginterferon alfa-2a	NA	NA	Moderate		Inter Info	[20], [21], [22]
D1329		Pravastatin	C23H36O7	54687	Moderate		Inter Info	[20], [21], [22]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[20], [21], [22]
D1504		Stavudine	C10H12N2O4	18283	Moderate		Inter Info	[20], [21], [22]
D1551		Teniposide	C32H32O13S	452548	Moderate		Inter Info	[20], [21], [22]
D1698		Vincristine	C46H56N4O10	5978	Moderate		Inter Info	[20], [21], [22]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Moderate		Inter Info	[20], [21], [22]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[20], [21], [22]
D1714		Zafirlukast	C31H33N3O6S	5717	Moderate		Inter Info	[20], [21], [22]
Pharmacodynamic antagonistic effects
	Antagonize the effect of vaccine/toxoid					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[12], [17], [18]
D1693		Vibrio cholerae CVD 103-HgR strain live antigen (live)	NA	NA	Major		Inter Info	[19]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0145		Balsalazide	C17H15N3O6	54585	Moderate		Inter Info	[51]
D1011		Mestranol	C21H26O2	6291	Moderate		Inter Info	[58], [59], [60]
D1155		Norfloxacin	C16H18FN3O3	4539	Moderate		Inter Info	[62], [63], [64]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[65], [66], [67]

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30	Product Information. Elspar (asparaginase). Merck & Co, Inc, West Point, PA.
31	Product Information. Erwinaze (asparaginase Erwinia chrysanthemi). EUSA Pharma, Newtown, PA.
32	Product Information. Oncaspar (pegaspargase). Rhone-Poulenc Rorer, Collegeville, PA.
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39	Product Information. Aczone (dapsone topical). QLT USA, Inc, Fort Collins, CO.
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44	Product Information. Betaseron (interferon beta-1b). Berlex, Richmond, CA.
45	Product Information. Plegridy (peginterferon beta-1a). Biogen Idec Inc, Cambridge, MA.
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