Drug General Information (ID: DDIKYA946J)
Drug Name			Nitrofurantoin		Drug Info		Norfloxacin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiinfective Agents				Antibiotics
Structure

Mechanism of Nitrofurantoin-Norfloxacin Interaction (Severity Level: Moderate)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Nitrofurantoin				Norfloxacin
Mechanism		Antagonize the antibacterial effect of norfloxacin in the urinary tract				Norfloxacin
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Nitrofurantoin when combined with Norfloxacin

Recommended Action
Management		The concomitant use of nitrofurantoin and norfloxacin is not recommended.

References
1	Product Information. Cipro (ciprofloxacin). Bayer, West Haven, CT.
2	Product Information. Noroxin (norfloxacin). Merck &amp Co, Inc, West Point, PA.
3	Yuk JH, Nightingale CH, Sweeney KR, Quintiliani R, Lettieri JT, Forst RW "Relative bioavailability in healthy volunteers of ciprofloxacin administered through a nasogastric tube with and without enteral feeding." Antimicrob Agents Chemother 33 (1989): 1118-20