Drug General Information (ID: DDIDYMGH1E)
  Drug Name Nitrofurantoin Drug Info Magnesium carbonate Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Antiinfective Agents Antacids
  Structure

 Mechanism of Nitrofurantoin-Magnesium carbonate Interaction (Severity Level: Minor)
     Complex formation Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Nitrofurantoin Magnesium carbonate
      Mechanism Binds to polyvalent cations Polyvalent cations
      Key Mechanism Factor 1
Factor Name Chelation
Factor Description Chelation is a direct drug interaction that usually involves the formation of dimers or trimers, resulting in larger complexes and poorer absorption.
      Mechanism Description
  • Decreased absorption of Magnesium carbonate due to formation of complexes caused by Nitrofurantoin 

References
1 Naggar VF, Khalil SA "Effect of magnesium trisilicate on nitrofurantoin absorption." Clin Pharmacol Ther 25 (1979): 857-63. [PMID: 36251]