Drug General Information (ID: DDIQPN04C5)
Drug Name			Hyoscyamine		Drug Info		Nitrofurantoin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiarrhythmic Agents				Antiinfective Agents
Structure

Mechanism of Hyoscyamine-Nitrofurantoin Interaction (Severity Level: Minor)
Altered gastrointestinal dynamics Click to Show/Hide Mechanism Graph
Drug Name		Hyoscyamine				Nitrofurantoin
Mechanism		Decrease gastrointestinal motility				Absorption is influenced by gastrointestinal motility
Key Mechanism Factor 1
		Factor Name		Gastrointestinal Motility
		Factor Description		Gastrointestinal motility is an important factor in determining the absorption of orally administered drugs, and it controls the residence time of the drug in the digestive tract.
Mechanism Description		Altered absorption of Nitrofurantoin due to GI dynamics variation caused by Hyoscyamine

References
1	Jaffe JM "Effect of propantheline on nitrofurantoin absorption." J Pharm Sci 64 (1975): 1729-30. [PMID: 1185550]
2	Mannisto P "The effect of crystal size, gastric content and emptying rate on the absorption of nitrofurantoin in healthy human volunteers." Int J Clin Pharmacol Biopharm 16 (1978): 223-8. [PMID: 649241]