Details of Drug

Drug General Information (ID: D1051)
Drug Name	Metronidazole
Drug Type	Small molecule
Drug Synonymous	APMN; Acromona; Anagiardil; Arilin; Atrivyl; Bexon; CONT; Clont; Danizol; Deflamon; Efloran; Elyzol; Entizol; Eumin; Flagemona; Flagesol; Flagil; Flagyl; Flegyl; Florazole; Fossyol; Giatricol; Gineflavir; Giniflavir; Klion; Klont; Meronidal; Methronidazole; Metric; MetroCream; MetroGel; MetroLotion; Metrodzhil; Metrogyl; Metrolag; Metrolyl; Metromidol; Metronidaz; Metronidazol; Metronidazolo; Metronidazolum; Metrotop; Metrozine; Metryl; Mexibol; Monagyl; Monasin; NIDA; Nalox; Nidagel; Noritate; Novonidazol; Orvagil; Protostat; Rathimed; Rosased; Sanatrichom; Satric; Takimetol; Trichazol; Trichex; Trichocide; Trichomol; Trichopal; Trichopol; Tricocet; Tricom; Trikacide; Trikamon; Trikojol; Trikozol; Trimeks; Trivazol; Vagilen; Vagimid; Vandazole; Vertisal; Wagitran; Zadstat; Zidoval; Flagyl Er; Ginefla vir; METRONIDAZOLE USP; Metro Cream; Metro Gel; Metronidazole Monohydrochloride; Metronidazole Phosphoester; Metronidazole in Plastic Container; Metronidazolo [DCIT]; Tricho cordes; Trichomonacid pharmachim; Tricowas B; Bayer 5360; Flagyl 375; M0924; Metric 21; RP 8823; SC 10295; Anabact (TN); Apo-Metronidazole; Deflamon-wirkstoff; Flagyl (TN); IDR-90105; METRO I.V; MetroGel (TN); MetroGel-Vaginal; Metronidazol [INN-Spanish]; Metronidazolum [INN-Latin]; Mexibol (silanes); Neo-Tric; Noritate (TN); RP-8823; Rozex (TN); Tricho-gynaedron; ZERO/004064; CB-01-14 MMX; FLAGYL I.V. RTU IN PLASTIC CONTAINER; Flagyl I.V.; Flagyl I.V. RTU; Metro I.V.; Metro I.V. In Plastic Container; Metrogel-vaginal (TN); Metronidazole (JP15/USP/INN); Metronidazole [USAN:INN:BAN:JAN]; Methyl-5-nitroimidazole-1-ethanol; 1-Hydroxyethyl-2-methyl-5-nitroimidazole; 2-(2-methyl-5-nitroimidazol-1-yl)ethanol; 2-Methyl-5-nitro-1-imidazoleethanol; 2-Methyl-5-nitroimidazole-1-ethanol; MNZ Click to Show/Hide
Disease Class	1A36: Amoebiasis; DD70: Crohn disease
Therapeutic Class	Antiinfective Agents
Structure
Structure	3D Structure		2D Structure
Formula	C6H9N3O3
InChI	1S/C6H9N3O3/c1-5-7-4-6(9(11)12)8(5)2-3-10/h4,10H,2-3H2,1H3
InChIKey	VAOCPAMSLUNLGC-UHFFFAOYSA-N
Canonical SMILES	CC1=NC=C(N1CCO)[N+](=O)[O-]
External Link
	Pubchem ID	4173
	CAS Number	443-48-1
	CHEBI ID	6909
	TTD ID	D0A2ZX
	INTEDE ID	DR1073

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM002 Altered intestinal flora BM014 Interference of cell/tissue uptake BM017 CYP450 enzyme inhibition BM018 Non-CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM025 Decreased metabolism (Unspecific) BM074 Increased risk of peripheral neuropathy BM076 Increased risk of prolong QT interval BM081 Increased risk of ventricular arrhythmias BM100 Antagonize the effect of vaccine/toxoid BM107 Attenuated pharmacological effects (Unspecific) BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Metronidazole
Affected gastrointestinal absorption
	Altered intestinal flora					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1095		Mycophenolic acid	C17H20O6	446541	Moderate		Inter Info	[72], [73]
D1094		Mycophenolate mofetil	C23H31NO7	5281078	Moderate		Inter Info	[72], [73]
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1817		Indium In-111 oxyquinoline	C27H18InN3O3	16685037	Moderate		Inter Info	[66]
D1822		Iodide I-123	I-	135300	Moderate		Inter Info	[67], [68], [69]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 18
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0481		Dicoumarol	C19H12O6	54676038	Major		Inter Info	[5], [6], [7]
D0087		Anisindione	C16H12O3	2197	Major		Inter Info	[18], [19], [5], [20], [21], [22], [23], [2], [6], [24], [25], [7], [26], [27]
D1711		Warfarin	C19H16O4	54678486	Major		Inter Info	[18], [19], [5], [20], [21], [22], [23], [2], [6], [24], [25], [7], [26], [27]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[40]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[44]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[45], [2], [4], [46]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[54], [55], [56], [57], [58]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[64], [65], [2], [4]
D0905		Lesinurad	C17H14BrN3O2S	53465279	Moderate		Inter Info	[70]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[71]
D1087		Montelukast	C35H36ClNO3S	5281040	Moderate		Inter Info	[76], [77]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[78], [79]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[64], [65], [2], [4]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[45], [80], [2], [4]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[81], [82], [83]
D1674		Valdecoxib	C16H14N2O3S	119607	Moderate		Inter Info	[84]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[85], [86]
D0337		Cimetidine	C10H16N6S	2756	Minor		Inter Info	[88], [89], [42], [4]
	Non-CYP450 enzyme inhibition					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0081		Amprenavir (oral solution)	C25H35N3O6S	65016	Major		Inter Info	[1], [2], [3], [4]
D0617		Ethanol	C2H6O	702	Major		Inter Info	[10], [11], [12], [13], [14], [15], [2], [16], [17]
	CYP450 enzyme induction					Drug Num: 10
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[41], [42], [43], [2], [4]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[41], [42], [43], [2], [4]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[41], [42], [2]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[41], [42], [43], [2], [4]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[41], [42], [43], [2], [4]
D1400		Rifampicin	C43H58N4O12	135398735	Moderate		Inter Info	[12], [4], [16]
D1401		Rifapentine	C47H64N4O12	135403821	Moderate		Inter Info	[4]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[41], [42], [43], [2], [4]
D1340		Primidone	C12H14N2O2	4909	Moderate		Inter Info	[41], [42], [43], [2], [4]
D1399		Rifabutin	C46H62N4O11	135398743	Moderate		Inter Info	[4]
	Decreased metabolism (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0223		Busulfan	C6H14O6S2	2478	Major		Inter Info	[28], [29], [30]
Pharmacodynamic additive effects
	Increased risk of peripheral neuropathy					Drug Num: 68
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Moderate		Inter Info	[34], [35], [36]
D0193		Bortezomib	C19H25BN4O4	387447	Moderate		Inter Info	[37], [38], [39]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[34], [35], [36]
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[34], [35], [36]
D0344		Cisplatin	Cl2H6N2Pt	5702198	Moderate		Inter Info	[34], [35], [36]
D0419		Dapsone	C12H12N2O2S	2955	Moderate		Inter Info	[34], [35], [36]
D0483		Didanosine	C10H12N4O3	135398739	Moderate		Inter Info	[34], [35], [36]
D0614		Etanercept	NA	NA	Moderate		Inter Info	[34], [35], [36]
D0616		Ethambutol	C10H24N2O2	14052	Moderate		Inter Info	[34], [35], [36]
D1731		Ethionamide	C8H10N2S	2761171	Moderate		Inter Info	[34], [35], [36]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[34], [35], [36]
D0802		Infliximab	NA	NA	Moderate		Inter Info	[34], [35], [36]
D0821		Interferon alfa-2a, Recombinant	NA	NA	Moderate		Inter Info	[34], [35], [36]
D0822		Interferon alfa-2b	C16H17Cl3I2N3NaO5S	71306834	Moderate		Inter Info	[34], [35], [36]
D0824		Interferon alfa-n1	NA	NA	Moderate		Inter Info	[34], [35], [36]
D0823		Interferon alfacon-1	NA	NA	Moderate		Inter Info	[34], [35], [36]
D0933		Linezolid	C16H20FN3O4	441401	Moderate		Inter Info	[34], [35], [36]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[34], [35], [36]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[34], [35], [36]
D0126		Auranofin	C20H34AuO9PS	24199313	Moderate		Inter Info	[34], [35], [36]
D0127		Aurothioglucose	C6H11AuO5S	454937	Moderate		Inter Info	[34], [35], [36]
D0162		Benznidazole	C12H12N4O3	31593	Moderate		Inter Info	[34], [35], [36]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[34], [59], [60]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[34], [35], [36]
D0260		Carboplatin	C6H12N2O4Pt	426756	Moderate		Inter Info	[34], [35], [36]
D0261		Carfilzomib	C40H57N5O7	11556711	Moderate		Inter Info	[34], [35], [36]
D0304		Certolizumab pegol	NA	NA	Moderate		Inter Info	[34], [35], [36]
D0380		Colchicine	C22H25NO6	6167	Moderate		Inter Info	[34], [35], [36]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[34], [35], [36]
D0501		Dinutuximab	NA	NA	Moderate		Inter Info	[34], [35], [36]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[34], [35], [36]
D0560		Elotuzumab	NA	NA	Moderate		Inter Info	[34], [35], [36]
D0571		Enfortumab vedotin	NA	NA	Moderate		Inter Info	[34], [35], [36]
D0594		Eribulin	C40H59NO11	11354606	Moderate		Inter Info	[34], [35], [36]
D0669		Fludarabine	C10H12FN5O4	657237	Moderate		Inter Info	[34], [35], [36]
D0686		Fluvastatin	C24H26FNO4	446155	Moderate		Inter Info	[34], [35], [36]
D0736		Golimumab	NA	NA	Moderate		Inter Info	[34], [35], [36]
D0770		Hydralazine	C8H8N4	3637	Moderate		Inter Info	[34], [35], [36]
D0841		Ipilimumab	NA	NA	Moderate		Inter Info	[34], [35], [36]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[34], [35], [36]
D0900		Leflunomide	C12H9F3N2O2	3899	Moderate		Inter Info	[34], [35], [36]
D0918		Levodopa	C9H11NO4	6047	Moderate		Inter Info	[34], [35], [36]
D1113		Naxitamab	NA	NA	Moderate		Inter Info	[34], [35], [36]
D1118		Nelarabine	C11H15N5O5	3011155	Moderate		Inter Info	[34], [35], [36]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[34], [35], [36]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[34], [35], [36]
D1301		Pitavastatin	C25H24FNO4	5282452	Moderate		Inter Info	[34], [35], [36]
D1306		Polatuzumab vedotin	NA	NA	Moderate		Inter Info	[34], [35], [36]
D1312		Pomalidomide	C13H11N3O4	134780	Moderate		Inter Info	[34], [35], [36]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[34], [35], [36]
D1430		Rosuvastatin	C22H28FN3O6S	446157	Moderate		Inter Info	[34], [35], [36]
D1452		Secnidazole	C7H11N3O3	71815	Moderate		Inter Info	[34], [35], [36]
D1479		Sodium aurothiomalate	C4H3AuNa2O4S	22318	Moderate		Inter Info	[34], [35], [36]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Moderate		Inter Info	[34], [35], [36]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[37], [48], [28], [74]
D1599		Tocilizumab	NA	NA	Moderate		Inter Info	[34], [35], [36]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[34], [35], [36]
D1623		Trastuzumab emtansine	NA	NA	Moderate		Inter Info	[34], [35], [36]
D1715		Zalcitabine	C9H13N3O3	24066	Moderate		Inter Info	[37], [75]
D1238		Peginterferon alfa-2b	NA	NA	Moderate		Inter Info	[34], [35], [36]
D1329		Pravastatin	C23H36O7	54687	Moderate		Inter Info	[34], [35], [36]
D1504		Stavudine	C10H12N2O4	18283	Moderate		Inter Info	[34], [35], [36]
D1551		Teniposide	C32H32O13S	452548	Moderate		Inter Info	[34], [35], [36]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[34], [35], [36]
D1698		Vincristine	C46H56N4O10	5978	Moderate		Inter Info	[34], [35], [36]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Moderate		Inter Info	[34], [35], [36]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[34], [35], [36]
D1714		Zafirlukast	C31H33N3O6S	5717	Moderate		Inter Info	[34], [35], [36]
	Increased risk of prolong QT interval					Drug Num: 177
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0947		Loperamide	C29H33ClN2O2	3955	Moderate		Inter Info	[52], [53]
D0003		Abarelix	C72H95ClN14O14	16131215	Minor		Inter Info	[48], [55], [2], [87]
D0036		Alfuzosin	C19H27N5O4	2092	Minor		Inter Info	[48], [55], [2], [87]
D0068		Amitriptyline	C20H23N	2160	Minor		Inter Info	[48], [55], [2], [87]
D0072		Amoxapine	C17H16ClN3O	2170	Minor		Inter Info	[48], [55], [2], [87]
D0084		Anagrelide	C10H7Cl2N3O	135409400	Minor		Inter Info	[48], [55], [2], [87]
D0097		Apomorphine	C17H17NO2	6005	Minor		Inter Info	[48], [55], [2], [87]
D0115		Astemizole	C28H31FN4O	2247	Minor		Inter Info	[48], [55], [2], [87]
D0119		Atomoxetine	C17H21NO	54841	Minor		Inter Info	[48], [55], [2], [87]
D0139		Azithromycin	C38H72N2O12	447043	Minor		Inter Info	[48], [55], [2], [87]
D0324		Chlorpromazine	C17H19ClN2S	2726	Minor		Inter Info	[48], [55], [2], [87]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Minor		Inter Info	[48], [55], [2], [87]
D0342		Cisapride	C23H29ClFN3O4	6917698	Minor		Inter Info	[48], [55], [2], [87]
D0345		Citalopram	C20H21FN2O	2771	Minor		Inter Info	[48], [55], [2], [87]
D0358		Clofazimine	C27H22Cl2N4	2794	Minor		Inter Info	[48], [55], [2], [87]
D0370		Clozapine	C18H19ClN4	135398737	Minor		Inter Info	[48], [55], [2], [87]
D0429		Daunorubicin	C27H29NO10	30323	Minor		Inter Info	[48], [55], [2], [87]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Minor		Inter Info	[12], [55], [15]
D0467		Dextropropoxyphene	C22H29NO2	10100	Minor		Inter Info	[12], [55], [15]
D0508		Disopyramide	C21H29N3O	3114	Minor		Inter Info	[48], [55], [2], [87]
D0513		Dofetilide	C19H27N3O5S2	71329	Minor		Inter Info	[48], [55], [2], [87]
D0514		Dolasetron	C19H20N2O3	3033818	Minor		Inter Info	[48], [55], [2], [87]
D0535		Droperidol	C22H22FN3O2	3168	Minor		Inter Info	[48], [55], [2], [87]
D0554		Efavirenz	C14H9ClF3NO2	64139	Minor		Inter Info	[48], [55], [2], [87]
D0584		Epirubicin	C27H29NO11	41867	Minor		Inter Info	[48], [55], [2], [87]
D0597		Erythromycin	C37H67NO13	12560	Minor		Inter Info	[48], [55], [2], [87]
D0667		Fluconazole	C13H12F2N6O	3365	Minor		Inter Info	[48], [55], [2], [87]
D0676		Fluoxetine	C17H18F3NO	3386	Minor		Inter Info	[48], [55], [2], [87]
D0678		Fluphenazine	C22H26F3N3OS	3372	Minor		Inter Info	[48], [55], [2], [87]
D0682		Flutamide	C11H11F3N2O3	3397	Minor		Inter Info	[48], [55], [2], [87]
D0694		Foscarnet	CH3O5P	3415	Minor		Inter Info	[48], [55], [2], [87]
D0737		Goserelin	C59H84N18O14	5311128	Minor		Inter Info	[48], [55], [2], [87]
D0738		Granisetron	C18H24N4O	5284566	Minor		Inter Info	[48], [55], [2], [87]
D0740		Grepafloxacin	C19H22FN3O3	72474	Minor		Inter Info	[48], [55], [2], [87]
D0750		Haloperidol	C21H23ClFNO2	3559	Minor		Inter Info	[48], [55], [2], [87]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Minor		Inter Info	[48], [55], [2], [87]
D0787		Ibutilide	C20H36N2O3S	60753	Minor		Inter Info	[48], [55], [2], [87]
D0795		Imipramine	C19H24N2	3696	Minor		Inter Info	[48], [55], [2], [87]
D0908		Leuprolide	C59H84N16O12	657181	Minor		Inter Info	[48], [55], [2], [87]
D0992		Mefloquine	C17H16F6N2O	4046	Minor		Inter Info	[48], [55], [2], [87]
D1017		Methadone	C21H27NO	4095	Minor		Inter Info	[48], [55], [2], [87]
D0007		Abiraterone	C24H31NO	132971	Minor		Inter Info	[48], [55], [2], [87]
D0037		Alimemazine	C18H22N2S	5574	Minor		Inter Info	[12], [55], [15]
D0067		Amisulpride	C17H27N3O4S	2159	Minor		Inter Info	[48], [55], [2], [87]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Minor		Inter Info	[48], [55], [2], [87]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Minor		Inter Info	[48], [55], [2], [87]
D0107		Arsenic trioxide	As2O3	14888	Minor		Inter Info	[48], [55], [2], [87]
D0112		Asenapine	C17H16ClNO	3036780	Minor		Inter Info	[48], [55], [2], [87]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Minor		Inter Info	[48], [55], [2], [87]
D0170		Bepridil	C24H34N2O	2351	Minor		Inter Info	[48], [55], [2], [87]
D0180		Bicalutamide	C18H14F4N2O4S	2375	Minor		Inter Info	[48], [55], [2], [87]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Minor		Inter Info	[48], [55], [2], [87]
D0219		Buprenorphine	C29H41NO4	644073	Minor		Inter Info	[48], [55], [2], [87]
D0230		Cabozantinib	C28H24FN3O5	25102847	Minor		Inter Info	[48], [55], [2], [87]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Minor		Inter Info	[48], [55], [2], [87]
D0336		Cilostazol	C20H27N5O2	2754	Minor		Inter Info	[48], [55], [2], [87]
D0361		Clomipramine	C19H23ClN2	2801	Minor		Inter Info	[48], [55], [2], [87]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Minor		Inter Info	[48], [55], [2], [87]
D0437		Degarelix	C82H103ClN18O16	16136245	Minor		Inter Info	[48], [55], [2], [87]
D0446		Desipramine	C18H22N2	2995	Minor		Inter Info	[48], [55], [2], [87]
D0452		Deutetrabenazine	C19H27NO3	73437646	Minor		Inter Info	[48], [55], [2], [87]
D0525		Doxepin	C19H21NO	667477	Minor		Inter Info	[48], [55], [2], [87]
D0526		Doxepin (topical)	C19H21NO	667477	Minor		Inter Info	[12], [55], [15]
D0528		Doxorubicin	C27H29NO11	31703	Minor		Inter Info	[48], [55], [2], [87]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Minor		Inter Info	[12], [55], [15]
D0534		Dronedarone	C31H44N2O5S	208898	Minor		Inter Info	[48], [55], [2], [87]
D0569		Encorafenib	C22H27ClFN7O4S	50922675	Minor		Inter Info	[48], [55], [2], [87]
D0577		Entrectinib	C31H34F2N6O2	25141092	Minor		Inter Info	[48], [55], [2], [87]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Minor		Inter Info	[48], [55], [2], [87]
D0599		Escitalopram	C20H21FN2O	146570	Minor		Inter Info	[48], [55], [2], [87]
D0632		Ezogabine	C16H18FN3O2	121892	Minor		Inter Info	[48], [55], [2], [87]
D0661		Fingolimod	C19H33NO2	107970	Minor		Inter Info	[48], [55], [2], [87]
D0664		Flecainide	C17H20F6N2O3	3356	Minor		Inter Info	[48], [55], [2], [87]
D0712		Gatifloxacin	C19H22FN3O4	5379	Minor		Inter Info	[48], [55], [2], [87]
D0716		Gemifloxacin	C18H20FN5O4	9571107	Minor		Inter Info	[48], [55], [2], [87]
D0720		Gilteritinib	C29H44N8O3	49803313	Minor		Inter Info	[48], [55], [2], [87]
D0725		Glasdegib	C21H22N6O	25166913	Minor		Inter Info	[48], [55], [2], [87]
D0749		Halofantrine	C26H30Cl2F3NO	37393	Minor		Inter Info	[48], [55], [2], [87]
D0751		Halothane	C2HBrClF3	3562	Minor		Inter Info	[48], [55], [2], [87]
D0758		Histrelin	C66H86N18O12	25077993	Minor		Inter Info	[48], [55], [2], [87]
D0788		Idarubicin	C26H27NO9	42890	Minor		Inter Info	[48], [55], [2], [87]
D0791		Iloperidone	C24H27FN2O4	71360	Minor		Inter Info	[48], [55], [2], [87]
D0806		Inotuzumab ozogamicin	NA	NA	Minor		Inter Info	[48], [55], [2], [87]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Minor		Inter Info	[48], [55], [2], [87]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Minor		Inter Info	[48], [55], [2], [87]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Minor		Inter Info	[48], [55], [2], [87]
D0899		Lefamulin	C28H45NO5S	25185057	Minor		Inter Info	[48], [55], [2], [87]
D0903		Lenvatinib	C21H19ClN4O4	9823820	Minor		Inter Info	[48], [55], [2], [87]
D0909		Levacetylmethadol	C23H31NO2	15130	Minor		Inter Info	[12], [55], [15]
D0919		Levofloxacin	C18H20FN3O4	149096	Minor		Inter Info	[48], [55], [2], [87]
D0937		Lisdexamfetamine	C15H25N3O	11597698	Minor		Inter Info	[48], [55], [2], [87]
D0942		Lofexidine	C11H12Cl2N2O	30668	Minor		Inter Info	[48], [55], [2], [87]
D0943		Lomefloxacin	C17H19F2N3O3	3948	Minor		Inter Info	[48], [55], [2], [87]
D0960		Lumefantrine	C30H32Cl3NO	6437380	Minor		Inter Info	[12], [55], [15]
D0965		Macimorelin	C26H30N6O3	9804938	Minor		Inter Info	[48], [55], [2], [87]
D0979		Maprotiline	C20H23N	4011	Minor		Inter Info	[48], [55], [2], [87]
D1010		Mesoridazine	C21H26N2OS2	4078	Minor		Inter Info	[48], [55], [2], [87]
D1026		Methotrimeprazine	C19H24N2OS	72287	Minor		Inter Info	[48], [55], [2], [87]
D1062		Midostaurin	C35H30N4O4	9829523	Minor		Inter Info	[48], [55], [2], [87]
D1136		Nilotinib	C28H22F3N7O	644241	Minor		Inter Info	[48], [55], [2], [87]
D1155		Norfloxacin	C16H18FN3O3	4539	Minor		Inter Info	[48], [55], [2], [87]
D1165		Ofloxacin	C18H20FN3O4	4583	Minor		Inter Info	[48], [55], [2], [87]
D1169		Oliceridine	C22H30N2O2S	66553195	Minor		Inter Info	[48], [55], [2], [87]
D1189		Osilodrostat	C13H10FN3	44139752	Minor		Inter Info	[48], [55], [2], [87]
D1190		Osimertinib	C28H33N7O2	71496458	Minor		Inter Info	[48], [55], [2], [87]
D1211		Ozanimod	C23H24N4O3	52938427	Minor		Inter Info	[48], [55], [2], [87]
D1215		Paliperidone	C23H27FN4O3	115237	Minor		Inter Info	[48], [55], [2], [87]
D1221		Panobinostat	C21H23N3O2	6918837	Minor		Inter Info	[48], [55], [2], [87]
D1230		Pasireotide	C58H66N10O9	9941444	Minor		Inter Info	[48], [55], [2], [87]
D1232		Pazopanib	C21H23N7O2S	10113978	Minor		Inter Info	[48], [55], [2], [87]
D1290		Pimavanserin	C25H34FN3O2	10071196	Minor		Inter Info	[48], [55], [2], [87]
D1292		Pimozide	C28H29F2N3O	16362	Minor		Inter Info	[48], [55], [2], [87]
D1302		Pitolisant	C17H26ClNO	9948102	Minor		Inter Info	[48], [55], [2], [87]
D1315		Posaconazole	C37H42F2N8O4	468595	Minor		Inter Info	[48], [55], [2], [87]
D1339		Primaquine	C15H21N3O	4908	Minor		Inter Info	[48], [55], [2], [87]
D1342		Probucol	C31H48O2S2	4912	Minor		Inter Info	[48], [55], [2], [87]
D1343		Procainamide	C13H21N3O	4913	Minor		Inter Info	[48], [55], [2], [87]
D1352		Promethazine	C17H20N2S	4927	Minor		Inter Info	[48], [55], [2], [87]
D1353		Propafenone	C21H27NO3	4932	Minor		Inter Info	[48], [55], [2], [87]
D1368		Quetiapine	C21H25N3O2S	5002	Minor		Inter Info	[48], [55], [2], [87]
D1388		Relugolix	C29H27F2N7O5S	10348973	Minor		Inter Info	[48], [55], [2], [87]
D1398		Ribociclib	C23H30N8O	44631912	Minor		Inter Info	[48], [55], [2], [87]
D1404		Rilpivirine	C22H18N6	6451164	Minor		Inter Info	[48], [55], [2], [87]
D1424		Romidepsin	C24H36N4O6S2	5352062	Minor		Inter Info	[48], [55], [2], [87]
D1432		Rucaparib	C19H18FN3O	9931954	Minor		Inter Info	[48], [55], [2], [87]
D1438		Salbutamol	C13H21NO3	2083	Minor		Inter Info	[12], [55], [15]
D1444		Saquinavir	C38H50N6O5	441243	Minor		Inter Info	[48], [55], [2], [87]
D1459		Selpercatinib	C29H31N7O3	134436906	Minor		Inter Info	[48], [55], [2], [87]
D1461		Sertraline	C17H17Cl2N	68617	Minor		Inter Info	[48], [55], [2], [87]
D1463		Sevoflurane	C4H3F7O	5206	Minor		Inter Info	[48], [55], [2], [87]
D1474		Siponimod	C29H35F3N2O3	44599207	Minor		Inter Info	[48], [55], [2], [87]
D1491		Solifenacin	C23H26N2O2	154059	Minor		Inter Info	[48], [55], [2], [87]
D1499		Sparfloxacin	C19H22F2N4O3	60464	Minor		Inter Info	[48], [55], [2], [87]
D1516		Sulfamethoxazole	C10H11N3O3S	5329	Minor		Inter Info	[47], [48], [28], [90], [91], [92], [93]
D1522		Sunitinib	C22H27FN4O2	5329102	Minor		Inter Info	[48], [55], [2], [87]
D1542		Telavancin	C80H106Cl2N11O27P	3081362	Minor		Inter Info	[48], [55], [2], [87]
D1544		Telithromycin	C43H65N5O10	3002190	Minor		Inter Info	[48], [55], [2], [87]
D1560		Tetrabenazine	C19H27NO3	6018	Minor		Inter Info	[48], [55], [2], [87]
D1634		Triclabendazole	C14H9Cl3N2OS	50248	Minor		Inter Info	[48], [55], [2], [87]
D1651		Triptorelin	C64H82N18O13	25074470	Minor		Inter Info	[48], [55], [2], [87]
D1673		Valbenazine	C24H38N2O4	24795069	Minor		Inter Info	[48], [55], [2], [87]
D1681		Vandetanib	C22H24BrFN4O2	3081361	Minor		Inter Info	[48], [55], [2], [87]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Minor		Inter Info	[48], [55], [2], [87]
D1063		Mifepristone	C29H35NO2	55245	Minor		Inter Info	[48], [55], [2], [87]
D1075		Mirtazapine	C17H19N3	4205	Minor		Inter Info	[48], [55], [2], [87]
D1092		Moxifloxacin	C21H24FN3O4	152946	Minor		Inter Info	[48], [55], [2], [87]
D1137		Nilutamide	C12H10F3N3O4	4493	Minor		Inter Info	[48], [55], [2], [87]
D1166		Olanzapine	C17H20N4S	135398745	Minor		Inter Info	[48], [55], [2], [87]
D1181		Ondansetron	C18H19N3O	4595	Minor		Inter Info	[48], [55], [2], [87]
D1210		Oxytocin	C43H66N12O12S2	439302	Minor		Inter Info	[48], [55], [2], [87]
D1216		Palonosetron	C19H24N2O	6337614	Minor		Inter Info	[48], [55], [2], [87]
D1246		Pentamidine	C19H24N4O2	4735	Minor		Inter Info	[48], [55], [2], [87]
D1254		Perflutren	C3F8	6432	Minor		Inter Info	[48], [55], [2], [87]
D1257		Perphenazine	C21H26ClN3OS	4748	Minor		Inter Info	[48], [55], [2], [87]
D1346		Prochlorperazine	C20H24ClN3S	4917	Minor		Inter Info	[48], [55], [2], [87]
D1351		Promazine	C17H20N2S	4926	Minor		Inter Info	[48], [55], [2], [87]
D1356		Propofol	C12H18O	4943	Minor		Inter Info	[48], [55], [2], [87]
D1361		Protriptyline	C19H21N	4976	Minor		Inter Info	[48], [55], [2], [87]
D1372		Quinine	C20H24N2O2	3034034	Minor		Inter Info	[48], [55], [2], [87]
D1383		Ranolazine	C24H33N3O4	56959	Minor		Inter Info	[48], [55], [2], [87]
D1413		Risperidone	C23H27FN4O2	5073	Minor		Inter Info	[48], [55], [2], [87]
D1497		Sorafenib	C21H16ClF3N4O3	216239	Minor		Inter Info	[48], [55], [2], [87]
D1498		Sotalol	C12H20N2O3S	5253	Minor		Inter Info	[48], [55], [2], [87]
D1533		Tamoxifen	C26H29NO	2733526	Minor		Inter Info	[48], [55], [2], [87]
D1554		Terbutaline	C12H19NO3	5403	Minor		Inter Info	[48], [55], [2], [87]
D1555		Terfenadine	C32H41NO2	5405	Minor		Inter Info	[48], [55], [2], [87]
D1574		Thioridazine	C21H26N2S2	5452	Minor		Inter Info	[48], [55], [2], [87]
D1596		Tizanidine	C9H8ClN5S	5487	Minor		Inter Info	[48], [55], [2], [87]
D1612		Toremifene	C26H28ClNO	3005573	Minor		Inter Info	[48], [55], [2], [87]
D1616		Tramadol	C16H25NO2	33741	Minor		Inter Info	[48], [55], [2], [87]
D1624		Trazodone	C19H22ClN5O	5533	Minor		Inter Info	[48], [55], [2], [87]
D1637		Trifluoperazine	C21H24F3N3S	5566	Minor		Inter Info	[48], [55], [2], [87]
D1638		Triflupromazine	C18H19F3N2S	5568	Minor		Inter Info	[48], [55], [2], [87]
D1683		Vasopressin	C46H65N15O12S2	644077	Minor		Inter Info	[48], [55], [2], [87]
D1689		Venlafaxine	C17H27NO2	5656	Minor		Inter Info	[48], [55], [2], [87]
D1706		Voriconazole	C16H14F3N5O	71616	Minor		Inter Info	[48], [55], [2], [87]
D1726		Ziprasidone	C21H21ClN4OS	60854	Minor		Inter Info	[48], [55], [2], [87]
	Increased risk of ventricular arrhythmias					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0516		Donepezil	C24H29NO3	3152	Moderate		Inter Info	[47], [48], [28], [49], [50], [51]
D0707		Galantamine	C17H21NO3	9651	Moderate		Inter Info	[47], [48], [28], [49], [50], [51]
D1418		Rivastigmine	C14H22N2O2	77991	Moderate		Inter Info	[47], [48], [28], [49], [50], [51]
D1525		Tacrine	C13H14N2	1935	Moderate		Inter Info	[47], [48], [28], [49], [50], [51]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0509		Disulfiram	C10H20N2S4	3117	Major		Inter Info	[3], [8], [9]
Pharmacodynamic antagonistic effects
	Antagonize the effect of vaccine/toxoid					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[28], [31], [32]
D1693		Vibrio cholerae CVD 103-HgR strain live antigen (live)	NA	NA	Major		Inter Info	[33]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[61], [62], [63]
D1011		Mestranol	C21H26O2	6291	Moderate		Inter Info	[61], [62], [63]

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