Drug General Information (ID: DDI1INER4G)
  Drug Name Metronidazole Drug Info Alimemazine Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Antiinfective Agents Antihistamines
  Structure

 Mechanism of Metronidazole-Alimemazine Interaction (Severity Level: Minor)
     Increased risk of prolong QT interval Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Metronidazole Alimemazine
      Mechanism Prolong QT interval Prolong QT interval
      Key Mechanism Factor 1
Factor Name QT interval
Factor Description Long QT syndrome is a heart signaling disorder that can cause a fast, chaotic heartbeat (arrhythmia). Many people may not exhibit symptoms, and usually the condition is detected during routine medical tests. In others, the most common symptoms include: sudden fainting, palpitations, dizziness, seizures, sudden death.
      Mechanism Description
  • Increased risk of prolong QT interval by the combination of Metronidazole and Alimemazine 

References
1 Giannini AJ, DeFrance DT "Metronidazole and alcohol: potential for combinative abuse." J Toxicol Clin Toxicol 20 (1983): 509-15. [PMID: 6668631]
2 Kounas SP, Letsas KP, Sideris A, Efraimidis M, Kardaras F "QT interval prolongation and torsades de pointes due to a coadministration of metronidazole and amiodarone." Pacing Clin Electrophysiol 28 (2005): 472-3. [PMID: 15869686]
3 Product Information. Benznidazole (benznidazole). Everett Laboratories Inc, West Orange, NJ.