Drug General Information (ID: DDIQUVWCAB)
Drug Name			Metronidazole		Drug Info		Telavancin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiinfective Agents				Glycopeptide Antibiotics
Structure

Mechanism of Metronidazole-Telavancin Interaction (Severity Level: Minor)
Increased risk of prolong QT interval Click to Show/Hide Mechanism Graph
Drug Name		Metronidazole				Telavancin
Mechanism		Prolong QT interval				Prolong QT interval
Key Mechanism Factor 1
		Factor Name		QT interval
		Factor Description		Long QT syndrome is a heart signaling disorder that can cause a fast, chaotic heartbeat (arrhythmia). Many people may not exhibit symptoms, and usually the condition is detected during routine medical tests. In others, the most common symptoms include: sudden fainting, palpitations, dizziness, seizures, sudden death.
Mechanism Description		Increased risk of prolong QT interval by the combination of Metronidazole and Telavancin

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Kounas SP, Letsas KP, Sideris A, Efraimidis M, Kardaras F "QT interval prolongation and torsades de pointes due to a coadministration of metronidazole and amiodarone." Pacing Clin Electrophysiol 28 (2005): 472-3. [PMID: 15869686]
3	Product Information. Flagyl (metronidazole). Searle, Skokie, IL.
4	Product Information. Pylera (bismuth subcitrate potassium/metronidazo/TCN). Aptalis Pharma, Birmingham, AL.