Details of Drug

Drug General Information (ID: D0927)
Drug Name	Lidocaine
Drug Type	Small molecule
Drug Synonymous	Alphacaine; Anestacon; Cappicaine; Cuivasil; Dalcaine; Dentipatch; DermaFlex; Dilocaine; Duncaine; EMBOLEX; Esracaine; Gravocain; Isicaina; Isicaine; Jetocaine; LIDOPEN; LQZ; Lanabiotic; Leostesin; Lidocaina; Lidocainum; Lidocaton; Lidoderm; Lignocaine; Lignocainum; Lingocaine; Maricaine; Octocaine; Remicaine; Rucaina; Solcain; Xilina; Xilocaina; Xllina; Xycaine; Xylestesin; Xylesthesin; Xylocain; Xylocaine; Xylocard; Xylocitin; Xylotox; Zingo; After Burn Double Strength Gel; After Burn Double Strength Spray; After Burn Gel; After Burn Spray; Anestacon Jelly; Cito optadren; Emla Cream; Lidocaine Carbonate; Lidocaine Hydrocarbonate; Lidocaine Monohydrochloride; Norwood Sunburn Spray; Rocephin Kit; Solarcaine aloe extraburn relief cream; Xilocaina [Italian]; Xylocaine Dental Ointment; Xylocaine Endotracheal; Xylocaine Test Dose; Xylocaine Viscous; CDS1_000283; L1026_SIGMA; Xylocaine CO2; Dentipatch (TN); ELA-Max; L-Caine; Lida-Mantle; Lidocaina [INN-Spanish]; Lidocaine (VAN); Lidocainum [INN-Latin]; Lidoject-1; Lidoject-2; Octocaine-100; Octocaine-50; Xylocaine (TN); Xylocaine 5% Spinal; Xylocaine-Mpf; Xylocaine-Mpf with Glucose; Xyloneural (free base); Zilactin-L; Lidocaine [USAN:INN:JAN]; Diethylaminoaceto-2,6-xylidide; Lidocaine (JP15/USP/INN); Alfa-Dietilamino-2,6-dimetilacetanilide; Alfa-Dietilamino-2,6-dimetilacetanilide [Italian]; Alpha-Diethylamino-2,6-dimethylacetanilide; Alpha-Diethylaminoaceto-2,6-xylidide; LIDOCAINE (73-58-6 (MONOHYDROCHLORIDE); Omega-Diethylamino-2,6-dimethylacetanilide; Alpha-(Diethylamino)-2,6-acetoxylidide; N-(2,6-dimethylphenyl)-N(2),N(2)-diethylglycinamide; N-(2,6-dimethylphenyl)-N~2~,N~2~-diethylglycinamide; 2-(Diethylamino)-2',6'-acetoxylidide; 2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide; 2-Diethylamino-N-(2,6-dimethyl-phenyl)-acetamide; 2-Diethylamino-N-(2,6-dimethylphenyl)acetamide Click to Show/Hide
Disease Class	9A76-9A78: Corneal disease; GA34: Female pelvic pain
Therapeutic Class	Anesthetics
Structure
Structure	3D Structure		2D Structure
Formula	C14H22N2O
InChI	1S/C14H22N2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4/h7-9H,5-6,10H2,1-4H3,(H,15,17)
InChIKey	NNJVILVZKWQKPM-UHFFFAOYSA-N
Canonical SMILES	CCN(CC)CC(=O)NC1=C(C=CC=C1C)C
External Link
	Pubchem ID	3676
	CAS Number	137-58-6
	CHEBI ID	6456
	TTD ID	D0X4RN
	INTEDE ID	DR0953
	VARIDT ID	DR00849

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM002 Affected cellular transport AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM010 Transporter inhibition BM013 Competitive binding of plasma proteins BM014 Interference of cell/tissue uptake BM016 Altered formation of CYP450 enzymes BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM024 Competitive inhibition of metabolic enzyme BM025 Decreased metabolism (Unspecific) BM026 Increased metabolism (Unspecific) BM038 Additive CNS depression effects BM042 Additive hypotensive effects BM045 Additive neuromuscular blocking effects BM049 Increased risk of atrioventricular block BM051 Increased risk of bradycardia BM052 Increased risk of cardiac depression BM069 Increased risk of lowers seizure threshold BM071 Increased risk of methemoglobinemia BM076 Increased risk of prolong QT interval BM078 Increased risk of rapid heart rate BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Lidocaine
Affected cellular transport
	Transporter inhibition					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0963		Lusutrombopag	C29H32Cl2N2O5S	49843517	Moderate		Inter Info	[156]
Affected organization distribution
	Competitive binding of plasma proteins					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1142		Nitazoxanide	C12H9N3O5S	41684	Moderate		Inter Info	[162]
D1376		Raloxifene	C28H27NO4S	5035	Minor		Inter Info	[194]
	Interference of cell/tissue uptake					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1817		Indium In-111 oxyquinoline	C27H18InN3O3	16685037	Moderate		Inter Info	[133]
D1906		Thallous Chloride	ClTl	24642	Moderate		Inter Info	[35], [176], [177]
Affected intra/extra-hepatic metabolism
	Altered formation of CYP450 enzymes					Drug Num: 18
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Moderate		Inter Info	[3], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57]
D0032		Alefacept	NA	NA	Moderate		Inter Info	[3], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57]
D0085		Anakinra	C20H23N5O7S2	146171046	Moderate		Inter Info	[3], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57]
D0614		Etanercept	NA	NA	Moderate		Inter Info	[3], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57]
D0802		Infliximab	NA	NA	Moderate		Inter Info	[3], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57]
D0246		Canakinumab	NA	NA	Moderate		Inter Info	[3], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57]
D0304		Certolizumab pegol	NA	NA	Moderate		Inter Info	[47], [49], [54]
D0564		Emapalumab	NA	NA	Moderate		Inter Info	[3], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57]
D0736		Golimumab	NA	NA	Moderate		Inter Info	[3], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57]
D0747		Guselkumab	NA	NA	Moderate		Inter Info	[3], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57]
D0875		Ixekizumab	NA	NA	Moderate		Inter Info	[3], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57]
D1403		Rilonacept	NA	NA	Moderate		Inter Info	[3], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57]
D1447		Sarilumab	NA	NA	Moderate		Inter Info	[3], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57]
D1448		Satralizumab	NA	NA	Moderate		Inter Info	[3], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57]
D1454		Secukinumab	NA	NA	Moderate		Inter Info	[3], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57]
D1467		Siltuximab	NA	NA	Moderate		Inter Info	[3], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57]
D1599		Tocilizumab	NA	NA	Moderate		Inter Info	[3], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57]
D1671		Ustekinumab	NA	NA	Moderate		Inter Info	[3], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57]
	CYP450 enzyme inhibition					Drug Num: 45
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0080		Amprenavir	C25H35N3O6S	65016	Major		Inter Info	[2], [3], [4], [5]
D0386		Conivaptan	C32H26N4O2	151171	Major		Inter Info	[25]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Major		Inter Info	[2], [3], [4], [5]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[40], [41]
D0084		Anagrelide	C10H7Cl2N3O	135409400	Moderate		Inter Info	[35], [3], [58]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[82], [83]
D0799		Indinavir	C36H47N5O4	5362440	Moderate		Inter Info	[84]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[85]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[89], [90], [91], [92]
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[93], [94]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[35], [3], [95], [96]
D0251		Capmatinib	C23H17FN6O	25145656	Moderate		Inter Info	[105]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[3], [106]
D0337		Cimetidine	C10H16N6S	2756	Moderate		Inter Info	[107], [108], [109], [110], [111], [112], [113]
D0375		Cobicistat	C40H53N7O5S2	25151504	Moderate		Inter Info	[3], [95]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[114]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[115]
D0439		Delavirdine	C22H28N6O3S	5625	Moderate		Inter Info	[116]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[117]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[118]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[93], [94]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[121]
D0724		Givosiran	C78H139N11O30	119058042	Moderate		Inter Info	[130]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[131]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[132]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Moderate		Inter Info	[134], [35], [135], [136], [137], [138], [139], [140], [141]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[142]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[146]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[35], [3], [147]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[148], [149], [150]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[155]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[35], [3], [159], [160]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[161]
D1160		Obeticholic acid	C26H44O4	447715	Moderate		Inter Info	[163]
D1189		Osilodrostat	C13H10FN3	44139752	Moderate		Inter Info	[164]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[3]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[169], [170], [171]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[156]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[172], [150]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[174], [175]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[181]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[35], [3], [182]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[183]
D0035		Alfentanil	C21H32N6O3	51263	Minor		Inter Info	[188], [189], [190]
	CYP450 enzyme induction					Drug Num: 51
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0545		Echinacea	NA	NA	Moderate		Inter Info	[35], [119]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[120]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[35], [151]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[35], [3], [156]
D0224		Butabarbital	C10H16N2O3	2479	Minor		Inter Info	[184], [185], [186]
D0225		Butalbital	C11H16N2O3	2481	Minor		Inter Info	[184], [185], [186]
D0028		Albendazole	C12H15N3O2S	2082	Minor		Inter Info	[184], [185], [186], [187]
D0061		Aminoglutethimide	C13H16N2O2	2145	Minor		Inter Info	[184], [185], [186], [187]
D0071		Amobarbital	C11H18N2O3	2164	Minor		Inter Info	[184], [185], [186]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Minor		Inter Info	[184], [185], [186], [187]
D0106		Armodafinil	C15H15NO2S	9690109	Minor		Inter Info	[184], [185], [186], [187]
D0178		Bexarotene	C24H28O2	82146	Minor		Inter Info	[184], [185], [186], [187]
D0194		Bosentan	C27H29N5O6S	104865	Minor		Inter Info	[184], [185], [186], [187]
D0255		Carbamazepine	C15H12N2O	2554	Minor		Inter Info	[184], [185], [186], [187]
D0300		Cenobamate	C10H10ClN5O2	11962412	Minor		Inter Info	[184], [185], [186], [187]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Minor		Inter Info	[184], [185], [186], [187]
D0432		Deferasirox	C21H15N3O4	214348	Minor		Inter Info	[184], [185], [186], [187]
D0453		Dexamethasone	C22H29FO5	5743	Minor		Inter Info	[184], [185], [186], [187]
D0554		Efavirenz	C14H9ClF3NO2	64139	Minor		Inter Info	[184], [185], [186], [187]
D0555		Elagolix	C32H30F5N3O5	11250647	Minor		Inter Info	[184], [185], [186], [187]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Minor		Inter Info	[184], [185], [186], [187]
D0639		Felbamate	C11H14N2O4	3331	Minor		Inter Info	[184], [185], [186], [187]
D0741		Griseofulvin	C17H17ClO6	441140	Minor		Inter Info	[184], [185], [186], [187]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Minor		Inter Info	[184], [185], [186], [187]
D0953		Lorlatinib	C21H19FN6O2	71731823	Minor		Inter Info	[184], [185], [186], [187]
D1040		Methylphenobarbital	C13H14N2O3	8271	Minor		Inter Info	[184], [185], [186]
D1078		Mitotane	C14H10Cl4	4211	Minor		Inter Info	[184], [185], [186], [187]
D1081		Modafinil	C15H15NO2S	4236	Minor		Inter Info	[184], [185], [186], [187]
D1099		Nafcillin	C21H22N2O5S	8982	Minor		Inter Info	[184], [185], [186], [187]
D1179		Omeprazole	C17H19N3O3S	4594	Minor		Inter Info	[184], [185], [186], [187]
D1190		Osimertinib	C28H33N7O2	71496458	Minor		Inter Info	[184], [185], [186], [187]
D1198		Oxcarbazepine	C15H12N2O2	34312	Minor		Inter Info	[184], [185], [186], [187]
D1248		Pentobarbital	C11H18N2O3	4737	Minor		Inter Info	[184], [185], [186]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Minor		Inter Info	[184], [185], [186], [187]
D1265		Phenobarbital	C12H12N2O3	4763	Minor		Inter Info	[3], [36], [192], [193], [39]
D1274		Phenylbutazone	C19H20N2O2	4781	Minor		Inter Info	[184], [185], [186], [187]
D1340		Primidone	C12H14N2O2	4909	Minor		Inter Info	[184], [185], [186]
D1399		Rifabutin	C46H62N4O11	135398743	Minor		Inter Info	[184], [185], [186], [187]
D1400		Rifampicin	C43H58N4O12	135398735	Minor		Inter Info	[184], [185], [187]
D1401		Rifapentine	C47H64N4O12	135403821	Minor		Inter Info	[184], [185], [186], [187]
D1433		Rufinamide	C10H8F2N4O	129228	Minor		Inter Info	[184], [185], [186], [187]
D1453		Secobarbital	C12H18N2O3	5193	Minor		Inter Info	[184], [185], [186]
D1493		Somapacitan	C54H95N13O20S2	129894493	Minor		Inter Info	[184], [185], [187]
D1502		St. John's Wort	NA	NA	Minor		Inter Info	[184], [185], [186], [187]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Minor		Inter Info	[184], [185], [186], [187]
D1538		Tazemetostat	C34H44N4O4	66558664	Minor		Inter Info	[184], [185], [186], [187]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Minor		Inter Info	[184], [185], [186], [187]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Minor		Inter Info	[184], [185], [186], [187]
D1128		Nevirapine	C15H14N4O	4463	Minor		Inter Info	[184], [185], [186], [187]
D1494		Somatotropin	NA	NA	Minor		Inter Info	[184], [185], [187]
D1652		Troglitazone	C24H27NO5S	5591	Minor		Inter Info	[184], [185], [186], [187]
	Competitive inhibition of metabolic enzyme					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1476		Sirolimus	C51H79NO13	5284616	Moderate		Inter Info	[173], [171]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[173], [171]
D1549		Temsirolimus	C56H87NO16	6918289	Moderate		Inter Info	[173], [171]
	Increased metabolism (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0517		Dopamine	C8H11NO2	681	Minor		Inter Info	[191]
Pharmacodynamic additive effects
	Additive CNS depression effects					Drug Num: 14
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[35], [3], [86]
D0356		Clobazam	C16H13ClN2O2	2789	Moderate		Inter Info	[35], [3], [86]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[35], [3], [86]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Moderate		Inter Info	[35], [3], [86]
D0604		Estazolam	C16H11ClN4	3261	Moderate		Inter Info	[35], [3], [86]
D0679		Flurazepam	C21H23ClFN3O	3393	Moderate		Inter Info	[35], [3], [86]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[35], [3], [86]
D1197		Oxazepam	C15H11ClN2O2	4616	Moderate		Inter Info	[35], [3], [86]
D1367		Quazepam	C17H11ClF4N2S	4999	Moderate		Inter Info	[35], [3], [86]
D1391		Remimazolam	C21H19BrN4O2	9867812	Moderate		Inter Info	[35], [3], [86]
D1598		Tocainide	C11H16N2O	38945	Moderate		Inter Info	[179], [180]
D1632		Triazolam	C17H12Cl2N4	5556	Moderate		Inter Info	[35], [3], [86]
D0951		Lorazepam	C15H10Cl2N2O2	3958	Moderate		Inter Info	[35], [3], [86]
D1547		Temazepam	C16H13ClN2O2	5391	Moderate		Inter Info	[35], [3], [86]
	Additive hypotensive effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1752		Bupivacaine (liposome)	C18H28N2O	2474	Major		Inter Info	[9], [10]
	Additive neuromuscular blocking effects					Drug Num: 12
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0122		Atracurium	C53H72N2O12+2	47319	Moderate		Inter Info	[97], [98], [99], [100], [101], [102]
D0343		Cisatracurium	C53H72N2O12+2	62887	Moderate		Inter Info	[97], [98], [99], [100], [101], [102]
D0522		Doxacurium	C56H78N2O16+2	60169	Moderate		Inter Info	[97], [98], [99], [100], [101], [102]
D1047		Metocurine	C40H48N2O6+2	21233	Moderate		Inter Info	[97], [98], [99], [100], [101], [102]
D1080		Mivacurium	C58H80N2O14+2	5281042	Moderate		Inter Info	[97], [98], [99], [100], [101], [102]
D1219		Pancuronium	C35H60N2O4+2	441289	Moderate		Inter Info	[97], [98], [99], [100], [101], [102]
D1295		Pipecuronium	C35H62N4O4+2	50192	Moderate		Inter Info	[97], [98], [99], [100], [101], [102]
D1384		Rapacuronium	C37H61N2O4+	5311399	Moderate		Inter Info	[97], [98], [99], [100], [101], [102]
D1420		Rocuronium	C32H53N2O4+	441290	Moderate		Inter Info	[97], [98], [99], [100], [101], [102]
D1659		Tubocurarine	C37H41N2O6+	6000	Moderate		Inter Info	[97], [98], [99], [100], [101], [102]
D1684		Vecuronium	C34H57N2O4+	39765	Moderate		Inter Info	[97], [98], [99], [100], [101], [102]
D1510		Succinylcholine	C14H30N2O4+2	5314	Moderate		Inter Info	[97], [98], [99], [100], [101], [102]
	Increased risk of atrioventricular block					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0885		Lacosamide	C13H18N2O3	219078	Moderate		Inter Info	[143]
D0992		Mefloquine	C17H16F6N2O	4046	Moderate		Inter Info	[3], [157], [158]
	Increased risk of bradycardia					Drug Num: 21
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0173		Betaxolol	C18H29NO3	2369	Moderate		Inter Info	[59], [60], [61]
D0602		Esmolol	C16H25NO4	59768	Moderate		Inter Info	[59], [60], [61]
D0117		Atenolol	C14H22N2O3	2249	Moderate		Inter Info	[59], [60], [61]
D0188		Bisoprolol	C18H31NO4	2405	Moderate		Inter Info	[59], [60], [61]
D0200		Bretylium	C11H17BrN+	2431	Moderate		Inter Info	[90], [104]
D0265		Carteolol	C16H24N2O3	2583	Moderate		Inter Info	[59], [60], [61]
D0267		Carvedilol	C24H26N2O4	2585	Moderate		Inter Info	[59], [60], [61]
D0787		Ibutilide	C20H36N2O3S	60753	Moderate		Inter Info	[90], [104]
D0884		Labetalol	C19H24N2O3	3869	Moderate		Inter Info	[59], [60], [61]
D0891		Lanreotide	C54H69N11O10S2	71349	Moderate		Inter Info	[144], [145]
D1098		Nadolol	C17H27NO4	39147	Moderate		Inter Info	[59], [60], [61]
D1114		Nebivolol	C22H25F2NO4	71301	Moderate		Inter Info	[59], [60], [61]
D1230		Pasireotide	C58H66N10O9	9941444	Moderate		Inter Info	[2], [35], [3], [165], [166]
D1244		Penbutolol	C18H29NO2	37464	Moderate		Inter Info	[59], [60], [61]
D1293		Pindolol	C14H20N2O2	4828	Moderate		Inter Info	[59], [60], [61]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[59], [60], [61]
D1428		Ropivacaine	C17H26N2O	175805	Moderate		Inter Info	[104]
D1585		Timolol	C13H24N4O3S	33624	Moderate		Inter Info	[59], [60], [61]
D1600		Tofacitinib	C16H20N6O	9926791	Moderate		Inter Info	[35], [158]
D1049		Metoprolol	C15H25NO3	4171	Moderate		Inter Info	[59], [60], [61]
D1163		Octreotide	C49H66N10O10S2	448601	Moderate		Inter Info	[144], [145]
	Increased risk of cardiac depression					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0508		Disopyramide	C21H29N3O	3114	Moderate		Inter Info	[62], [63]
	Increased risk of lowers seizure threshold					Drug Num: 11
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0220		Bupropion	C13H18ClNO	444	Major		Inter Info	[11], [12], [2], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24]
D0833		Iohexol	C19H26I3N3O9	3730	Major		Inter Info	[26], [27], [28], [29], [30]
D0834		Iopamidol	C17H22I3N3O8	65492	Major		Inter Info	[26], [27], [28], [29], [30]
D1616		Tramadol	C16H25NO2	33741	Major		Inter Info	[42], [23], [22], [43]
D0054		Amifampridine	C5H7N3	5918	Moderate		Inter Info	[87], [88]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[35], [3]
D0722		Ginkgo biloba	NA	NA	Moderate		Inter Info	[122], [123], [124], [125], [126], [127], [128], [129]
D0932		Lindane	C6H6Cl6	727	Moderate		Inter Info	[152], [153], [154]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[167], [3], [168]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Moderate		Inter Info	[167], [168], [3]
D1488		Sodium sulfate	Na2O4S	24436	Moderate		Inter Info	[167], [168], [3]
	Increased risk of methemoglobinemia					Drug Num: 11
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1148		Nitrous acid	HNO2	24529	Major		Inter Info	[31], [32], [33]
D1337		Prilocaine	C13H20N2O	4906	Major		Inter Info	[34], [35], [3], [36], [37], [38], [39]
D1338		Prilocaine (topical)	C13H20N2O	4906	Major		Inter Info	[2], [35], [39]
D0163		Benzocaine (topical)	C9H11NO2	2337	Moderate		Inter Info	[3], [36], [103]
D0339		Cinchocaine (topical)	C20H29N3O2	3025	Moderate		Inter Info	[3], [36], [103]
D0377		Cocaine (nasal)	C17H21NO4	446220	Moderate		Inter Info	[3], [36], [103]
D0378		Cocaine (topical)	C17H21NO4	446220	Moderate		Inter Info	[3], [36], [103]
D1852		Oxybuprocaine (ophthalmic)	C17H28N2O3	4633	Moderate		Inter Info	[3], [36], [103]
D1870		Proparacaine (ophthalmic)	C16H26N2O3	4935	Moderate		Inter Info	[3], [36], [103]
D1904		Tetracaine (ophthalmic)	C15H24N2O2	5411	Moderate		Inter Info	[3], [36], [103]
D1562		Tetracaine (topical)	C15H24N2O2	5411	Moderate		Inter Info	[3], [36], [103]
	Increased risk of prolong QT interval					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0513		Dofetilide	C19H27N3O5S2	71329	Major		Inter Info	[1]
	Increased risk of rapid heart rate					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0101		Arbutamine	C18H23NO4	60789	Major		Inter Info	[6], [7], [8]
Pharmacodynamic antagonistic effects
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1909		Tilmanocept	NA	NA	Moderate		Inter Info	[178]

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