Drug General Information (ID: DDIJPYWCXF)
  Drug Name Lidocaine Drug Info Dopamine Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Anesthetics Cardiotonic Agents
  Structure

 Mechanism of Lidocaine-Dopamine Interaction (Severity Level: Minor)
     Increased metabolism (Unspecific) Click to Show/Hide Mechanism Graph
      Drug Name Lidocaine Dopamine
      Mechanism Lidocaine Enhance hepatic lidocaine elimination
      Key Mechanism Factor 1
Factor Name Pharmacokinetics
Factor Description Alters the metabolism of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
      Mechanism Description
  • Increased metabolism of Lidocaine caused by Dopamine 

References
1 Sprung J, Bourke DL, Schoenwald PK, Whalley D, Gottlieb A, Mascha EJ, Kapural L "Small-dose dopamine increases epidural lidocaine requirements during peripheral vascular surgery in elderly patients." Anesth Analg 90 (2000): 388-92. [PMID: 10648327]