Drug General Information (ID: DDIAYO4NRT)
Drug Name			Disopyramide		Drug Info		Lidocaine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiarrhythmic Agents				Anesthetics
Structure

Mechanism of Disopyramide-Lidocaine Interaction (Severity Level: Moderate)
Increased risk of cardiac depression Click to Show/Hide Mechanism Graph
Drug Name		Disopyramide				Lidocaine
Mechanism		Cardiac depressant effects				Cardiac depressant effects
Key Mechanism Factor 1
		Factor Name		Cardiac depression
		Factor Description		Cardiac depression may manifest as negative heart rate, negative conduction, and negative contractility. Symptoms include: excessive or more than normal sleep, irritability, loss of interest in activities, and fatigue.
Mechanism Description		Increased risk of cardiac depression by the combination of Disopyramide and Lidocaine

Recommended Action
Management		Patients should be closely monitored for hemodynamic and electrocardiographic evidence of efficacy and toxicity during concomitant administration.

References
1	Ellrodt G, Singh BN "Adverse effects of disopyramide (norpace): toxic interactions with other antiarrhythmic agents." Heart Lung 9 (1980): 469-74. [PMID: 6901519]
2	Product Information. Norpace (disopyramide). Searle, Skokie, IL.