Details of Drug Interaction

Details of Drug-Drug Interaction

 Drug General Information (ID: DDIYLXC39Z)
  Drug Name Lidocaine Drug Info Tubocurarine Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Anesthetics Neuromuscular Blocking Agents
  Structure

 Mechanism of Lidocaine-Tubocurarine Interaction (Severity Level: Moderate)
     Additive neuromuscular blocking effects Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Lidocaine Tubocurarine
      Mechanism Potentiates neuromuscular blockade Neuromuscular blocking agent
Neuronal acetylcholine receptor  Antagonist
      Key Mechanism Factor 1
Factor Name Neuronal acetylcholine receptor Structure Sequence
Protein Family Ligand-gated ion channel (TC 1.A.9) family
Protein Function
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
    Click to Show/Hide
      Mechanism Description
  • Additive neuromuscular blocking effects by the combination of Lidocaine and Tubocurarine 

Recommended Action
      Management Patients should be closely monitored for increased and/or prolonged neuromuscular blockade and apnea during and after concomitant therapy.

References
1 Bruckner J, Thomas KC, Bikhazi GB, Foldes FF "Neuromuscular drug interactions of clinical importance." Anesth Analg 59 (1980): 678-82. [PMID: 7191227]
2 Fukuda S, Wakuta K, Ishikawa T, Oshita S, Sakabe T, Takeshita H "Lidocaine modifies the effect of succinylcholine on muscle oxygen consumption in dogs." Anesth Analg 66 (1987): 325-8. [PMID: 3565794]
3 Harrah MD, Way WL, Katzung BG "The interaction of d-tubocurarine with antiarrhythmic drugs." Anesthesiology 33 (1970): 406-10. [PMID: 5512329]
4 Matsuo S, Rao DBS, Chaudry I, Foldes FF "Interaction of muscle relaxants and local anesthetics at the neuromuscular junction." Anesth Analg 57 (1978): 580-7. [PMID: 568429]
5 Miller RD, Way WL "Inhibition of succinylcholine-induced increased intragastric pressure by nondepolarizing muscle relaxants and lidocaine." Anesthesiology 34 (1971): 185-8. [PMID: 4250986]
6 Pouttu J, Tuominen MK, Rosenberg PH "Cardiovascular responses caused by the combination of lidocaine and vecuronium in the induction of general anaesthesia." Acta Anaesthesiol Scand 32 (1988): 549-52. [PMID: 2903604]