Details of Drug

Drug General Information (ID: D0879)
Drug Name	Ketamine
Drug Type	Small molecule
Drug Synonymous	Calypsol; Cetamina; Green; Ketaject; Ketalar; Ketaminum; Ketanest; Ketoject; Ketolar; Tekam; KETAMINE HCL; Ketalar base; Ketamine Base; Special K; Special K [street name]; CLSTA 20; T385; Cetamina [INN-Spanish]; Dl-Ketamine; Ketalar (TN); Ketamine (INN); Ketamine [INN:BAN]; Ketaminum [INN-Latin]; Ketanest (TN); Ketaset (TN); Tekam (TN); Cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)-(9CI); Cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)-, (+-)-(9CI); Cyclohexanone, 2-(o-chlorophenyl)-2-(methylamino)-, (+/-)-(8CI); (+/-)-2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone; (+/-)-2-(o-Chlorophenyl)-2-(methylamino)cyclohexanone; 2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone; 2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one; 2-(Methylamino)-2-(2-chlorophenyl)cyclohexanone; 2-(o-Chlorophenyl)-2-(methylamino)-cyclohexanone; 2-(o-Chlorophenyl)-2-(methylamino)cyclohexanone Click to Show/Hide
Disease Class	9A76-9A78: Corneal disease
Therapeutic Class	Analgesics
Structure
Structure	3D Structure		2D Structure
Formula	C13H16ClNO
InChI	1S/C13H16ClNO/c1-15-13(9-5-4-8-12(13)16)10-6-2-3-7-11(10)14/h2-3,6-7,15H,4-5,8-9H2,1H3
InChIKey	YQEZLKZALYSWHR-UHFFFAOYSA-N
Canonical SMILES	CNC1(CCCCC1=O)C2=CC=CC=C2Cl
External Link
	Pubchem ID	3821
	CAS Number	6740-88-1
	CHEBI ID	6121
	TTD ID	D0UM7O
	INTEDE ID	DR0903
	VARIDT ID	DR00685

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM024 Competitive inhibition of metabolic enzyme BM036 Additive cardiorespiratory depression effects BM038 Additive CNS depression effects BM041 Additive hypertensive effects BM042 Additive hypotensive effects BM045 Additive neuromuscular blocking effects BM078 Increased risk of rapid heart rate BM081 Increased risk of ventricular arrhythmias BM107 Attenuated pharmacological effects (Unspecific) BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Ketamine
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 14
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[27]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[31]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[32]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[43]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[44]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[19], [14], [45]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[46]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[47]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[48]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[52], [53], [54], [55], [56], [57], [58], [59], [60]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[50]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[14], [61]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[65]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[19], [14], [71], [72]
	CYP450 enzyme induction					Drug Num: 10
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0044		Alpelisib	C19H22F3N5O2S	56649450	Moderate		Inter Info	[14], [28]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[29]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[14], [30]
D0545		Echinacea	NA	NA	Moderate		Inter Info	[19], [33]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[49]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[19], [14], [50]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Moderate		Inter Info	[51]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[19], [14], [62], [63]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[14], [64]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[19], [14], [63]
	Competitive inhibition of metabolic enzyme					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Moderate		Inter Info	[19], [35], [36]
D1127		Netupitant	C30H32F6N4O	6451149	Moderate		Inter Info	[19], [35], [36]
Pharmacodynamic additive effects
	Additive cardiorespiratory depression effects					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0698		Fospropofol	C13H21O5P	3038498	Moderate		Inter Info	[37], [38], [39], [40], [41], [42]
D1356		Propofol	C12H18O	4943	Moderate		Inter Info	[37], [38], [39], [40], [41], [42]
	Additive CNS depression effects					Drug Num: 202
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0467		Dextropropoxyphene	C22H29NO2	10100	Major		Inter Info	[1], [2], [3]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[7], [8]
D1485		Sodium oxybate	C4H7NaO3	23663870	Major		Inter Info	[9], [10]
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[11], [12], [13]
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[11], [12], [13]
D0097		Apomorphine	C17H17NO2	6005	Moderate		Inter Info	[15], [16]
D0098		Apraclonidine	C9H10Cl2N4	2216	Moderate		Inter Info	[17], [14], [18]
D0135		Azatadine	C20H22N2	19861	Moderate		Inter Info	[11], [12], [13]
D0137		Azelastine (nasal)	C22H24ClN3O	2267	Moderate		Inter Info	[11], [12], [13]
D0160		Benzatropine	C21H25NO	1201549	Moderate		Inter Info	[11], [12], [13]
D0183		Biperiden	C21H29NO	2381	Moderate		Inter Info	[11], [12], [13]
D0205		Brimonidine (ophthalmic)	C11H10BrN5	2435	Moderate		Inter Info	[17], [14], [18]
D0206		Brimonidine (topical)	C11H10BrN5	2435	Moderate		Inter Info	[17], [14], [18]
D0212		Bromocriptine	C32H40BrN5O5	31101	Moderate		Inter Info	[11], [12], [13]
D0214		Brompheniramine	C16H19BrN2	6834	Moderate		Inter Info	[11], [12], [13]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[11], [12], [13]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[11], [12], [13]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[11], [12], [13]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[11], [12], [13]
D0226		Butorphanol	C21H29NO2	5361092	Moderate		Inter Info	[11], [12], [13]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[11], [12], [13]
D0259		Carbinoxamine	C16H19ClN2O	2564	Moderate		Inter Info	[11], [12], [13]
D0263		Carisoprodol	C12H24N2O4	2576	Moderate		Inter Info	[11], [12], [13]
D0305		Cetirizine	C21H25ClN2O3	2678	Moderate		Inter Info	[21], [22]
D0317		Chlordiazepoxide	C16H14ClN3O	2712	Moderate		Inter Info	[11], [12], [13]
D0318		Chlormezanone	C11H12ClNO3S	2717	Moderate		Inter Info	[11], [12], [13]
D0322		Chlorphenesin	C9H11ClO3	7697	Moderate		Inter Info	[11], [12], [13]
D0323		Chlorpheniramine	C16H19ClN2	2725	Moderate		Inter Info	[11], [12], [13]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[11], [12], [13]
D0327		Chlorzoxazone	C7H4ClNO2	2733	Moderate		Inter Info	[11], [12], [13]
D0345		Citalopram	C20H21FN2O	2771	Moderate		Inter Info	[11], [12], [13]
D0351		Clemastine	C21H26ClNO	26987	Moderate		Inter Info	[11], [12], [13]
D0356		Clobazam	C16H13ClN2O2	2789	Moderate		Inter Info	[11], [12], [13]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[11], [12], [13]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[11], [12], [13]
D0379		Codeine	C18H21NO3	5284371	Moderate		Inter Info	[11], [12], [13]
D0397		Cyclizine	C18H22N2	6726	Moderate		Inter Info	[11], [12], [13]
D0398		Cyclobenzaprine	C20H21N	2895	Moderate		Inter Info	[11], [12], [13]
D0403		Cyproheptadine	C21H21N	2913	Moderate		Inter Info	[11], [12], [13]
D0417		Dantrolene	C14H10N4O5	6914273	Moderate		Inter Info	[11], [12], [13]
D0456		Dexbrompheniramine	C16H19BrN2	16960	Moderate		Inter Info	[11], [12], [13]
D0459		Dexmedetomidine	C13H16N2	5311068	Moderate		Inter Info	[11], [12], [13]
D0466		Dextromethorphan	C18H25NO	5360696	Moderate		Inter Info	[11], [12], [13]
D0470		Dezocine	C16H23NO	3033053	Moderate		Inter Info	[11], [12], [13]
D0502		Diphenhydramine	C17H21NO	3100	Moderate		Inter Info	[11], [12], [13]
D0504		Diphenoxylate	C30H32N2O2	13505	Moderate		Inter Info	[11], [12], [13]
D0526		Doxepin (topical)	C19H21NO	667477	Moderate		Inter Info	[11], [12], [13]
D0532		Doxylamine	C17H22N2O	3162	Moderate		Inter Info	[11], [12], [13]
D0533		Dronabinol	C21H30O2	16078	Moderate		Inter Info	[11], [12], [13]
D0535		Droperidol	C22H22FN3O2	3168	Moderate		Inter Info	[11], [12], [13]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[11], [12], [13]
D0575		Entacapone	C14H15N3O5	5281081	Moderate		Inter Info	[11], [12], [13]
D0599		Escitalopram	C20H21FN2O	146570	Moderate		Inter Info	[11], [12], [13]
D0604		Estazolam	C16H11ClN4	3261	Moderate		Inter Info	[11], [12], [13]
D0612		Eszopiclone	C17H17ClN6O3	969472	Moderate		Inter Info	[11], [12], [13]
D0617		Ethanol	C2H6O	702	Moderate		Inter Info	[19], [14], [24]
D0620		Ethosuximide	C7H11NO2	3291	Moderate		Inter Info	[11], [12], [13]
D0621		Ethotoin	C11H12N2O2	3292	Moderate		Inter Info	[11], [12], [13]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[11], [12], [13]
D0646		Fentanyl	C22H28N2O	3345	Moderate		Inter Info	[11], [12], [13]
D0662		Flavoxate	C24H25NO4	3354	Moderate		Inter Info	[11], [12], [13]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[11], [12], [13]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[11], [12], [13]
D0679		Flurazepam	C21H23ClFN3O	3393	Moderate		Inter Info	[11], [12], [13]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[11], [12], [13]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[11], [12], [13]
D0748		Halazepam	C17H12ClF3N2O	31640	Moderate		Inter Info	[11], [12], [13]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[11], [12], [13]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[11], [12], [13]
D0776		Hydromorphone	C17H19NO3	5284570	Moderate		Inter Info	[11], [12], [13]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Moderate		Inter Info	[11], [12], [13]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[11], [12], [13]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[11], [12], [13]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[11], [12], [13]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[11], [12], [13]
D0161		Benzhydrocodone	C25H25NO4	49836084	Moderate		Inter Info	[11], [12], [13]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Moderate		Inter Info	[11], [12], [13]
D0208		Brivaracetam	C11H20N2O2	9837243	Moderate		Inter Info	[11], [12], [13]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[11], [12], [13]
D0311		Chloral hydrate	C2H3Cl3O2	2707	Moderate		Inter Info	[11], [12], [13]
D0359		Clofedanol	C17H20ClNO	2795	Moderate		Inter Info	[11], [12], [13]
D0451		Desvenlafaxine	C16H25NO2	125017	Moderate		Inter Info	[11], [12], [13]
D0452		Deutetrabenazine	C19H27NO3	73437646	Moderate		Inter Info	[11], [12], [13]
D0471		Diamorphine	C21H23NO5	5462328	Moderate		Inter Info	[11], [12], [13]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[11], [12], [13]
D0600		Esketamine	C13H16ClNO	182137	Moderate		Inter Info	[19], [34]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[11], [12], [13]
D0632		Ezogabine	C16H18FN3O2	121892	Moderate		Inter Info	[11], [12], [13]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[7]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[11], [12], [13]
D0791		Iloperidone	C24H27FN2O4	71360	Moderate		Inter Info	[11], [12], [13]
D0878		Kava	C14H16O3	5281052	Moderate		Inter Info	[11], [12], [13]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[11], [12], [13]
D0917		Levocetirizine	C21H25ClN2O3	1549000	Moderate		Inter Info	[21], [22]
D0940		Lithium carbonate	CLi2O3	11125	Moderate		Inter Info	[11], [12], [13]
D0942		Lofexidine	C11H12Cl2N2O	30668	Moderate		Inter Info	[11], [12], [13]
D0959		Lumateperone	C24H28FN3O	21302490	Moderate		Inter Info	[11], [12], [13]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[11], [12], [13]
D1006		Mepyramine	C17H23N3O	4992	Moderate		Inter Info	[11], [12], [13]
D1026		Methotrimeprazine	C19H24N2OS	72287	Moderate		Inter Info	[11], [12], [13]
D1032		Methsuximide	C12H13NO2	6476	Moderate		Inter Info	[11], [12], [13]
D1046		Metoclopramide	C14H22ClN3O2	4168	Moderate		Inter Info	[11], [12], [13]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[11], [12], [13]
D1182		Opicapone	C15H10Cl2N4O6	135565903	Moderate		Inter Info	[11], [12], [13]
D1183		Opium	NA	NA	Moderate		Inter Info	[11], [12], [13]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[11], [12], [13]
D1224		Paraldehyde	C6H12O3	31264	Moderate		Inter Info	[11], [12], [13]
D1252		Pentoxyverine	C20H31NO3	2562	Moderate		Inter Info	[11], [12], [13]
D1253		Perampanel	C23H15N3O	9924495	Moderate		Inter Info	[11], [12], [13]
D1264		Phenindamine	C19H19N	11291	Moderate		Inter Info	[11], [12], [13]
D1282		Phenyltoloxamine	C17H21NO	7077	Moderate		Inter Info	[11], [12], [13]
D1367		Quazepam	C17H11ClF4N2S	4999	Moderate		Inter Info	[11], [12], [13]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[11], [12], [13]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[11], [12], [13]
D1431		Rotigotine	C19H25NOS	59227	Moderate		Inter Info	[11], [12], [13]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[11], [12], [13]
D1502		St. John's Wort	NA	NA	Moderate		Inter Info	[11], [12], [13]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[11], [12], [13]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[11], [12], [13]
D1535		Tapentadol	C14H23NO	9838022	Moderate		Inter Info	[11], [12], [13]
D1536		Tasimelteon	C15H19NO2	10220503	Moderate		Inter Info	[11], [12], [13]
D1560		Tetrabenazine	C19H27NO3	6018	Moderate		Inter Info	[11], [12], [13]
D1576		Thiothixene	C23H29N3O2S2	941651	Moderate		Inter Info	[11], [12], [13]
D1673		Valbenazine	C24H38N2O4	24795069	Moderate		Inter Info	[11], [12], [13]
D1675		Valerian	NA	NA	Moderate		Inter Info	[11], [12], [13]
D1719		Ziconotide	C102H172N36O32S7	16135415	Moderate		Inter Info	[11], [12], [13]
D0890		Lamotrigine	C9H7Cl2N5	3878	Moderate		Inter Info	[11], [12], [13]
D0912		Levetiracetam	C8H14N2O2	5284583	Moderate		Inter Info	[11], [12], [13]
D0923		Levorphanol	C17H23NO	5359272	Moderate		Inter Info	[11], [12], [13]
D0951		Lorazepam	C15H10Cl2N2O2	3958	Moderate		Inter Info	[11], [12], [13]
D0957		Loxapine	C18H18ClN3O	3964	Moderate		Inter Info	[11], [12], [13]
D0979		Maprotiline	C20H23N	4011	Moderate		Inter Info	[11], [12], [13]
D0987		Meclizine	C25H27ClN2	4034	Moderate		Inter Info	[11], [12], [13]
D1001		Meperidine	C15H21NO2	4058	Moderate		Inter Info	[66], [67], [68], [69], [70]
D1003		Mephenytoin	C12H14N2O2	4060	Moderate		Inter Info	[11], [12], [13]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[11], [12], [13]
D1014		Metaxalone	C12H15NO3	15459	Moderate		Inter Info	[11], [12], [13]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[11], [12], [13]
D1019		Methdilazine	C18H20N2S	14677	Moderate		Inter Info	[11], [12], [13]
D1023		Methocarbamol	C11H15NO5	4107	Moderate		Inter Info	[11], [12], [13]
D1035		Methyldopa	C10H13NO4	38853	Moderate		Inter Info	[11], [12], [13]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[11], [12], [13]
D1053		Metyrosine	C10H13NO3	441350	Moderate		Inter Info	[11], [12], [13]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[11], [12], [13]
D1089		Morphine	C17H19NO3	5288826	Moderate		Inter Info	[11], [12], [13]
D1090		Morphine (liposomal)	C17H19NO3	5288826	Moderate		Inter Info	[11], [12], [13]
D1096		Nabilone	C24H36O3	5284592	Moderate		Inter Info	[11], [12], [13]
D1100		Nalbuphine	C21H27NO4	5311304	Moderate		Inter Info	[11], [12], [13]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[11], [12], [13]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[11], [12], [13]
D1172		Olopatadine (nasal)	C21H23NO3	5281071	Moderate		Inter Info	[73], [74], [20]
D1188		Orphenadrine	C18H23NO	4601	Moderate		Inter Info	[11], [12], [13]
D1197		Oxazepam	C15H11ClN2O2	4616	Moderate		Inter Info	[11], [12], [13]
D1203		Oxycodone	C18H21NO4	5284603	Moderate		Inter Info	[11], [12], [13]
D1208		Oxymorphone	C17H19NO4	5284604	Moderate		Inter Info	[11], [12], [13]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[11], [12], [13]
D1247		Pentazocine	C19H27NO	441278	Moderate		Inter Info	[11], [12], [13]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[11], [12], [13]
D1255		Pergolide	C19H26N2S	47811	Moderate		Inter Info	[11], [12], [13]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[11], [12], [13]
D1260		Phenacemide	C9H10N2O2	4753	Moderate		Inter Info	[11], [12], [13]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[11], [12], [13]
D1269		Phensuximide	C11H11NO2	6839	Moderate		Inter Info	[11], [12], [13]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[11], [12], [13]
D1292		Pimozide	C28H29F2N3O	16362	Moderate		Inter Info	[11], [12], [13]
D1325		Pramipexole	C10H17N3S	119570	Moderate		Inter Info	[11], [12], [13]
D1335		Pregabalin	C8H17NO2	5486971	Moderate		Inter Info	[11], [12], [13]
D1340		Primidone	C12H14N2O2	4909	Moderate		Inter Info	[11], [12], [13]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[11], [12], [13]
D1347		Procyclidine	C19H29NO	4919	Moderate		Inter Info	[11], [12], [13]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[11], [12], [13]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[11], [12], [13]
D1355		Propiomazine	C20H24N2OS	4940	Moderate		Inter Info	[11], [12], [13]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[11], [12], [13]
D1390		Remifentanil	C20H28N2O5	60815	Moderate		Inter Info	[11], [12], [13]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[11], [12], [13]
D1427		Ropinirole	C16H24N2O	5095	Moderate		Inter Info	[11], [12], [13]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[11], [12], [13]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[11], [12], [13]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[11], [12], [13]
D1512		Sufentanil	C22H30N2O2S	41693	Moderate		Inter Info	[11], [12], [13]
D1547		Temazepam	C16H13ClN2O2	5391	Moderate		Inter Info	[11], [12], [13]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[75]
D1572		Thiethylperazine	C22H29N3S2	5440	Moderate		Inter Info	[11], [12], [13]
D1578		Tiagabine	C20H25NO2S2	60648	Moderate		Inter Info	[11], [12], [13]
D1604		Tolcapone	C14H11NO5	4659569	Moderate		Inter Info	[11], [12], [13]
D1609		Topiramate	C12H21NO8S	5284627	Moderate		Inter Info	[11], [12], [13]
D1616		Tramadol	C16H25NO2	33741	Moderate		Inter Info	[11], [12], [13]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[11], [12], [13]
D1632		Triazolam	C17H12Cl2N4	5556	Moderate		Inter Info	[11], [12], [13]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[11], [12], [13]
D1641		Trihexyphenidyl	C20H31NO	5572	Moderate		Inter Info	[11], [12], [13]
D1642		Trimethadione	C6H9NO3	5576	Moderate		Inter Info	[11], [12], [13]
D1644		Trimethobenzamide	C21H28N2O5	5577	Moderate		Inter Info	[11], [12], [13]
D1649		Tripelennamine	C16H21N3	5587	Moderate		Inter Info	[11], [12], [13]
D1650		Triprolidine	C19H22N2	5282443	Moderate		Inter Info	[11], [12], [13]
D1677		Valproic acid	C8H16O2	3121	Moderate		Inter Info	[11], [12], [13]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[11], [12], [13]
D1716		Zaleplon	C17H15N5O	5719	Moderate		Inter Info	[11], [12], [13]
D1726		Ziprasidone	C21H21ClN4OS	60854	Moderate		Inter Info	[11], [12], [13]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[11], [12], [13]
D1730		Zonisamide	C8H8N2O3S	5734	Moderate		Inter Info	[11], [12], [13]
	Additive hypertensive effects					Drug Num: 47
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0377		Cocaine (nasal)	C17H21NO4	446220	Moderate		Inter Info	[19], [14], [24]
D0510		Dobutamine	C18H23NO3	36811	Moderate		Inter Info	[19], [14], [24]
D0583		Epinephrine (topical)	C9H13NO3	5816	Moderate		Inter Info	[19], [14], [24]
D0593		Ergotamine	C33H35N5O5	8223	Moderate		Inter Info	[19], [14], [24]
D0641		Fenfluramine	C12H16F3N	3337	Moderate		Inter Info	[19], [14], [24]
D0644		Fenoldopam	C16H16ClNO3	3341	Moderate		Inter Info	[19], [14], [24]
D0691		Formoterol	C19H24N2O4	3410	Moderate		Inter Info	[19], [14], [24]
D0579		Ephedrine	C10H15NO	9294	Moderate		Inter Info	[19], [14], [24]
D0778		Hydroxyamphetamine (ophthalmic)	C9H13NO	3651	Moderate		Inter Info	[19], [14], [24]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[19], [14], [24]
D0857		Isometheptene	C9H19N	22297	Moderate		Inter Info	[19], [14], [24]
D0918		Levodopa	C9H11NO4	6047	Moderate		Inter Info	[19], [14], [24]
D0920		Levomilnacipran	C15H22N2O	6917779	Moderate		Inter Info	[19], [14], [24]
D0924		Levosalbutamol	C13H21NO3	123600	Moderate		Inter Info	[19], [14], [24]
D0937		Lisdexamfetamine	C15H25N3O	11597698	Moderate		Inter Info	[19], [14], [24]
D1012		Metamfetamine	C10H15N	10836	Moderate		Inter Info	[19], [14], [24]
D1036		Methylene blue	C16H18ClN3S	6099	Moderate		Inter Info	[19], [14], [24]
D1066		Milnacipran	C15H22N2O	65833	Moderate		Inter Info	[19], [14], [24]
D1108		Naphazoline (ophthalmic)	C14H14N2	4436	Moderate		Inter Info	[19], [14], [24]
D1171		Olodaterol	C21H26N2O5	11504295	Moderate		Inter Info	[19], [14], [24]
D1211		Ozanimod	C23H24N4O3	52938427	Moderate		Inter Info	[19], [14], [24]
D1262		Phendimetrazine	C12H17NO	30487	Moderate		Inter Info	[19], [14], [24]
D1358		Propylhexedrine (nasal)	C10H21N	7558	Moderate		Inter Info	[19], [14], [24]
D1437		Safinamide	C17H19FN2O2	131682	Moderate		Inter Info	[19], [14], [24]
D1492		Solriamfetol	C10H14N2O2	10130337	Moderate		Inter Info	[19], [14], [24]
D1567		Tetryzoline (nasal)	C13H16N2	5419	Moderate		Inter Info	[19], [14], [24]
D1568		Tetryzoline (ophthalmic)	C13H16N2	5419	Moderate		Inter Info	[19], [14], [24]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Moderate		Inter Info	[19], [14], [24]
D0933		Linezolid	C16H20FN3O4	441401	Moderate		Inter Info	[19], [14], [24]
D0983		Mecamylamine	C11H21N	4032	Moderate		Inter Info	[19], [14], [24]
D1037		Methylergometrine	C20H25N3O2	8226	Moderate		Inter Info	[19], [14], [24]
D1043		Methysergide	C21H27N3O2	9681	Moderate		Inter Info	[19], [14], [24]
D1153		Norepinephrine	C8H11NO3	439260	Moderate		Inter Info	[19], [14], [24]
D1185		Orciprenaline	C11H17NO3	4086	Moderate		Inter Info	[19], [14], [24]
D1204		Oxymetazoline (nasal)	C16H24N2O	4636	Moderate		Inter Info	[19], [14], [24]
D1205		Oxymetazoline (ophthalmic)	C16H24N2O	4636	Moderate		Inter Info	[19], [14], [24]
D1206		Oxymetazoline (topical)	C16H24N2O	4636	Moderate		Inter Info	[19], [14], [24]
D1270		Phentermine	C10H15N	4771	Moderate		Inter Info	[19], [14], [24]
D1276		Phenylephrine	C9H13NO2	6041	Moderate		Inter Info	[19], [14], [24]
D1277		Phenylephrine (nasal)	C9H13NO2	6041	Moderate		Inter Info	[19], [14], [24]
D1278		Phenylephrine (ophthalmic)	C9H13NO2	6041	Moderate		Inter Info	[19], [14], [24]
D1279		Phenylephrine (otic)	C9H13NO2	6041	Moderate		Inter Info	[19], [14], [24]
D1280		Phenylephrine (topical)	C9H13NO2	6041	Moderate		Inter Info	[19], [14], [24]
D1363		Pseudoephedrine	C10H15NO	7028	Moderate		Inter Info	[19], [14], [24]
D1440		Salmeterol	C25H37NO4	5152	Moderate		Inter Info	[19], [14], [24]
D1554		Terbutaline	C12H19NO3	5403	Moderate		Inter Info	[19], [14], [24]
D1683		Vasopressin	C46H65N15O12S2	644077	Moderate		Inter Info	[19], [14], [24]
	Additive hypotensive effects					Drug Num: 11
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[14]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[14]
D0444		Deserpidine	C32H38N2O8	8550	Moderate		Inter Info	[25], [26]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[14]
D0525		Doxepin	C19H21NO	667477	Moderate		Inter Info	[14]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[14]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[14]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[14]
D1361		Protriptyline	C19H21N	4976	Moderate		Inter Info	[14]
D1393		Reserpine	C33H40N2O9	5770	Moderate		Inter Info	[25], [26]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[14]
	Additive neuromuscular blocking effects					Drug Num: 10
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0343		Cisatracurium	C53H72N2O12+2	62887	Moderate		Inter Info	[19], [14], [23]
D0522		Doxacurium	C56H78N2O16+2	60169	Moderate		Inter Info	[19], [14], [23]
D0122		Atracurium	C53H72N2O12+2	47319	Moderate		Inter Info	[19], [14], [23]
D1047		Metocurine	C40H48N2O6+2	21233	Moderate		Inter Info	[19], [14], [23]
D1080		Mivacurium	C58H80N2O14+2	5281042	Moderate		Inter Info	[19], [14], [23]
D1219		Pancuronium	C35H60N2O4+2	441289	Moderate		Inter Info	[19], [14], [23]
D1295		Pipecuronium	C35H62N4O4+2	50192	Moderate		Inter Info	[19], [14], [23]
D1384		Rapacuronium	C37H61N2O4+	5311399	Moderate		Inter Info	[19], [14], [23]
D1684		Vecuronium	C34H57N2O4+	39765	Moderate		Inter Info	[19], [14], [23]
D1510		Succinylcholine	C14H30N2O4+2	5314	Moderate		Inter Info	[19], [14], [23]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0853		Isocarboxazid	C12H13N3O2	3759	Major		Inter Info	[4], [5], [6]
D1263		Phenelzine	C8H12N2	3675	Major		Inter Info	[4], [5], [6]
D1455		Selegiline	C13H17N	26757	Major		Inter Info	[4], [5], [6]
D1620		Tranylcypromine	C9H11N	19493	Major		Inter Info	[4], [5], [6]
D0143		Baclofen	C10H12ClNO2	2284	Moderate		Inter Info	[19], [14], [20]
Pharmacodynamic antagonistic effects
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1573		Thiopental	C11H18N2O2S	3000715	Minor		Inter Info	[19], [24], [76]

References
1	Hansen BS, Dam M, Brandt J, et al "Influence of dextropropoxyphene on steady state serum levels and protein binding of three anti-epileptic drugs in man." Acta Neurol Scand 61 (1980): 357-67. [PMID: 6998251]
2	Peterson GR, Covault HP, Hostetler RM "Acute inhibition of microsomal drug metabolism by propoxphene in narcotic tolerant/dependent mice." Life Sci 22 (1978): 2087-96. [PMID: 566834]
3	Abernethy DR, Greenblatt DJ, Morse DS, Shader RI "Interaction of propoxyphene with diazepam, alprazolam and lorazepam." Br J Clin Pharmacol 19 (1985): 51-7. [PMID: 2858217]
4	Product Information. Azilect (rasagiline). Teva Pharmaceuticals USA, North Wales, PA.
5	Product Information. Marplan (isocarboxazid) Roche Laboratories, Nutley, NJ.
6	Product Information. Nardil (phenelzine). Parke-Dvis, Morris Plains, NJ.
7	Product Information. Addyi (flibanserin). Sprout Pharmaceuticals, Raleigh, NC.
8	Product Information. Orlaam (levomethadyl acetate) Roxanne Laboratories Inc, Columbus, OH.
9	Product Information. Xywav (calcium/magnesium/potass/sodium oxybates). Jazz Pharmaceuticals, Palo Alto, CA.
10	Product Information. Xyrem (sodium oxybate). Orphan Medical, Minnetonka, MN.
11	Divoll M, Greenblatt DJ, Lacasse Y, Shader RI "Benzodiazepine overdosage: plasma concentrations and clinical outcome." Psychopharmacology (Berl) 73 (1981): 381-3. [PMID: 6789361]
12	Grabowski BS, Cady WJ, Young WW, Emery JF "Effects of acute alcohol administration on propranolol absorption." Int J Clin Pharmacol Ther Toxicol 18 (1980): 317-9. [PMID: 7429677]
13	Product Information. Belsomra (suvorexant). Merck &amp Company Inc, Whitehouse Station, NJ.
14	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
15	Product Information. Apokyn (apomorphine). Mylan Pharmaceuticals Inc, Morgantown, WV.
16	Product Information. Zohydro ER (HYDROcodone). Zogenix, Inc, San Diego, CA.
17	Product Information. Alphagan (brimonidine ophthalmic). Allergan Inc, Irvine, CA.
18	Product Information. Mirvaso (brimonidine topical). Galderma Laboratories Inc, Cranbury, NJ.
19	Cerner Multum, Inc. "Australian Product Information.".
20	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
21	Product Information. Zyrtec (cetirizine). Pfizer US Pharmaceuticals, New York, NY.
22	Product Information. Xyzal (levocetirizine). UCB Pharma Inc, Smyrna, GA.
23	Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA."
24	Product Information. Ketalar (ketamine). JHP Pharmaceuticals, Saddle River, NJ.
25	Ziegler CH, Lovette JB "Operative complications after therapy with reserpine and reserpine compounds." JAMA 176 (1961): 114-7
26	Jahr JS, Weber S "Ventricular dysrhythmias following an alfentanil anesthetic in a patient on reserpine for hypertension." Acta Anaesthesiol Scand 35 (1991): 788-9
27	Product Information. Xeglyze (abametapir topical). Dr. Reddy's Laboratories Inc, Upper Saddle River, NJ.
28	Product Information. Piqray (alpelisib). Novartis Pharmaceuticals, East Hanover, NJ.
29	Product Information. Xcopri (cenobamate). SK Life Science, Inc., Paramus, NJ.
30	Product Information. Tafinlar (dabrafenib). GlaxoSmithKline, Research Triangle Park, NC.
31	Product Information. Prezista (darunavir). Ortho Biotech Inc, Bridgewater, NJ.
32	Product Information. Copiktra (duvelisib). Verastem, Inc., Needham, MA.
33	Gorski JC, Huang SM, Pinto A, et al. "The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo." Clin Pharmacol Ther 75 (2004): 89-100. [PMID: 14749695]
34	Product Information. Spravato (esketamine). Janssen Pharmaceuticals, Titusville, NJ.
35	Product Information. Akynzeo (netupitant-palonosetron). Eisai Inc, Woodcliff Lake, NJ.
36	Product Information. Akynzeo for Injection (fosnetupitant-palonosetron). Helsinn Therapeutics Inc, Woodbridge Township, NJ.
37	Gill SS, Wright EM, Reilly CS "Pharmacokinetic interaction of propofol and fentanyl: single bolus injection study." Br J Anaesth 65 (1990): 760-5. [PMID: 2265045]
38	Hamaoka N, Oda Y, Hase I, Mizutani K, Nakamoto T, Ishizaki T, Asada A "Propofol decreases the clearance of midazolam by inhibiting CYP3A4: An in vivo and in vitro study." Clin Pharmacol Ther 66 (1999): 110-7. [PMID: 10460064]
39	McClune S, McKay AC, Wright PM, et al "Synergistic interaction between midazolam and propofol." Br J Anaesth 69 (1992): 240-5. [PMID: 1389840]
40	Pavlin DJ, Coda B, Shen DD, et al "Effects of combining propofol and alfentanil on ventilation, analgesia, sedation, and emesis in human volunteers." Anesthesiology 84 (1996): 23-37. [PMID: 8572340]
41	Product Information. Diprivan (propofol). Zeneca Pharmaceuticals, Wilmington, DE.
42	Product Information. Lusedra (fospropofol). Eisai Inc, Teaneck, NJ.
43	Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
44	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
45	Product Information. Vitrakvi (larotrectinib). Bayer Pharmaceutical Inc, West Haven, CT.
46	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
47	Product Information. Prevymis (letermovir). Merck & Company Inc, Whitehouse Station, NJ.
48	Product Information. Zokinvy (lonafarnib). Eiger BioPharmaceuticals, Palo Alto, CA.
49	Product Information. Lorbrena (lorlatinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
50	EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring.".
51	Product Information. Turalio (pexidartinib). Daiichi Sankyo, Inc., Parsippany, NJ.
52	DSouza DL, Levasseur LM, Nezamis J, Robbins DK, Simms L, Koch KM "Effect of alosetron on the pharmacokinetics of alprazolam." J Clin Pharmacol 41 (2001): 452-4. [PMID: 11304902]
53	Kane GC, Lipsky JJ "Drug-grapefruit juice interactions." Mayo Clin Proc 75 (2000): 933-42. [PMID: 10994829]
54	Katoh M, Nakajima M, Yamazaki H, Yokoi T "Inhibitory effects of CYP3A4 substrates and their metabolites on P-glycoprotein-mediated transport." Eur J Pharm Sci 12 (2001): 505-13. [PMID: 11231118]
55	Nagy J, Schipper HG, Koopmans RP, Butter JJ, van Boxtel CJ, Kager PA "Effect of grapefruit juice or cimetidine coadministration on albendazole bioavailability." Am J Trop Med Hyg 66 (2002): 260-3. [PMID: 12139218]
56	Product Information. Kisqali (ribociclib). Novartis Pharmaceuticals, East Hanover, NJ.
57	Rawden HC, Kokwaro GO, Ward SA, Edwards G "Relative contribution of cytochromes P-450 and flavin-containing monoxygenases to the metabolism of albendazole by human liver microsomes." Br J Clin Pharmacol 49 (2000): 313-22. [PMID: 10759686]
58	Trivier JM, Libersa C, Belloc C, Lhermitte M "Amiodarone N-deethylation in human liver microsomes: involvement of cytochrome P450 3A enzymes (first report)." Life Sci 52 (1993): pl91-6. [PMID: 8445979]
59	Yu DK "The contribution of P-glycoprotein to pharmacokinetic drug-drug interactions." J Clin Pharmacol 39 (1999): 1203-11. [PMID: 10586385]
60	Zhou XJ, Zhou-Pan XR, Gauthier T, Placidi M, Maurel P, Rahmani R "Human liver microsomal cytochrome P450 3A isozymes mediated vindesine biotransformation. Metabolic drug interactions." Biochem Pharmacol 45 (1993): 853-61. [PMID: 8452560]
61	Product Information. Retevmo (selpercatinib). Lilly, Eli and Company, Indianapolis, IN.
62	Product Information. Humatrope (somatropin). Lilly, Eli and Company, Indianapolis, IN.
63	Product Information. Zorbtive (somatropin). Serono Laboratories Inc, Rockland, MA.
64	Product Information. Xermelo (telotristat ethyl). Lexicon Pharmaceuticals, Inc., The Woodlands, TX.
65	Product Information. Tukysa (tucatinib). Seattle Genetics Inc, Bothell, WA.
66	Lambertsen CJ, Wendel H, Longenhagen JB "The separate and combined respiratory effects of chlorpromazine and meperidine in normal men controlled at 46 mm Hg alveolar pCO2." J Pharmacol Exp Ther 131 (1961): 381-93. [PMID: 13758472]
67	Hoffman JC, Smith TC "The respiratory effects of meperidine and propiomazine in man." Anesthesiology 32 (1970): 325-31. [PMID: 4392394]
68	Stambaugh JE, Wainer IW "Drug interaction: meperidine and chlorpromazine, a toxic combination." J Clin Pharmacol 21 (1981): 140-6. [PMID: 7240435]
69	Product Information. Meperidine Hydrochloride Injection, USP (meperidine) Astra-Zeneca Pharmaceuticals, Wilmington, DE.
70	Product Information. Demerol (meperidine). Sanofi Winthrop Pharmaceuticals, New York, NY.
71	He K, Woolf TF, Hollenberg PF "Mechanism-based inactivation of cytochrome P-450-3A4 by mifepristone (RU486)." J Pharmacol Exp Ther 288 (1999): 791-7. [PMID: 9918590]
72	Product Information. Mifeprex (mifepristone) Danco Laboratories, New York, NY.
73	Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
74	Product Information. Patanase (olopatadine nasal). Alcon Laboratories Inc, Fort Worth, TX.
75	Product Information. Thalomid (thalidomide). Celgene Corporation, Warren, NJ.
76	Manani G, valenti S, Vincenti E, et al. "Interaction between thiopentone and subhypnotic doses of ketamine." Eur J Anaesthesiol 9 (1992): 43-7

Details of Drug

Details of Drug

Cite MecDDI

About MecDDI

Correspondence