Drug General Information (ID: DDIDIAVL2J)
Drug Name			Ketamine		Drug Info		Safinamide		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Analgesics				Dopaminergic Antiparkinsonism Agents
Structure

Mechanism of Ketamine-Safinamide Interaction (Severity Level: Moderate)
Additive hypertensive effects Click to Show/Hide Mechanism Graph
Drug Name		Ketamine				Safinamide
Mechanism 1		Hypertensive effects				Hypertensive effects
Key Mechanism Factor 1
		Factor Name		Hypertensive effects
		Factor Description		Hypertension is defined as a blood pressure reading above a prescribed limit (130/90 mmHg). Most people with hypertension have no signs or symptoms; others may experience: severe headache, shortness of breath, nosebleeds, severe anxiety, and feeling a tingling sensation in the neck or head.
Mechanism Description		Additive hypertensive effects by the combination of Ketamine and Safinamide
Increased risk of rapid heart rate Click to Show/Hide Mechanism Graph
Drug Name		Ketamine				Safinamide
Mechanism 2		Tachycardia				Tachycardia
Key Mechanism Factor 2
		Factor Name		Tachycardia
		Factor Description		A faster-than-normal heart rate, but the heart is beating normally. Tachycardia may not cause any symptoms or complications, but if left untreated, some forms of tachycardia can lead to serious health problems, including heart failure, stroke, or sudden cardiac death.
Mechanism Description		Increased risk of rapid heart rate by the combination of Ketamine and Safinamide

Recommended Action
Management		Close monitoring of vital signs, including blood pressure and heart rate is recommended whenever ketamine is used concomitantly with direct or indirect acting sympathomimetics or vasopressin.

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	Product Information. Ketalar (ketamine). JHP Pharmaceuticals, Saddle River, NJ.