Drug General Information (ID: DDIPM3A5B4)
Drug Name			Cisatracurium		Drug Info		Ketamine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Neuromuscular Blocking Agents				Analgesics
Structure

Mechanism of Cisatracurium-Ketamine Interaction (Severity Level: Moderate)
Additive neuromuscular blocking effects Click to Show/Hide Mechanism Graph
Drug Name		Cisatracurium				Ketamine
Mechanism		Neuromuscular blocking agent Neuronal acetylcholine receptor  Antagonist				Potentiates neuromuscular blockade
Key Mechanism Factor 1
		Factor Name		Neuronal acetylcholine receptor				Structure Sequence
		Protein Family		Ligand-gated ion channel (TC 1.A.9) family
		Protein Function		After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.     Click to Show/Hide
Mechanism Description		Additive neuromuscular blocking effects by the combination of Cisatracurium and Ketamine

Recommended Action
Management		Until more information is available, caution is recommended during concomitant use.

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA."