Drug General Information (ID: DDIM89HSFO)
Drug Name			Thiopental		Drug Info		Ketamine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anxiolytics/Sedatives/Hypnotics				Analgesics
Structure

Mechanism of Thiopental-Ketamine Interaction (Severity Level: Minor)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Thiopental				Ketamine
Mechanism		Thiopental				Decrease the hypnotic effect of thiopental
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Thiopental when combined with Ketamine

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Product Information. Ketalar (ketamine). JHP Pharmaceuticals, Saddle River, NJ.
3	Manani G, valenti S, Vincenti E, et al. "Interaction between thiopentone and subhypnotic doses of ketamine." Eur J Anaesthesiol 9 (1992): 43-7