Details of Drug

Drug General Information (ID: D1573)
Drug Name	Thiopental
Drug Type	Small molecule
Drug Synonymous	Intraval; Penthiobarbital; Pentothiobarbital; Thiomebumal; Thionembutal; Thiopentobarbital; Thiopentobarbitone; Thiopentone; Thiothal; Tiopentale; Trapanal; Thiopental [BAN]; Thiopental solution; Thiopentobarbituric acid; Tiopentale [Italian]; Sodium Pentothal (TN); Thiopental (TN); Thiopentone sodium (TN); Trapanal (TN); (+-)-Thiopental; (+/-)-THIOPENTAL; (+/-)-Thiopental solution; 2-Thio-5-ethyl-5-sec-pentylbarbituric acid; 4,6,(1H,5H)-Pyrimidinedione, 5-ethyldihydro-5-(1-methylbutyl)-2-thioxo-(9CI); 5-Ethyl-5-(1-methyl-butyl)-2-thioxo-dihydro-pyrimidine-4,6-dione; 5-Ethyl-5-(1-methylbutyl)-2-thiobarbituric acid; 5-ethyl-2-mercapto-5-(1-methylbutyl)pyrimidine-4,6(1H,5H)-dione; 5-ethyl-5-(1-methylbutyl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione; 5-ethyl-5-pentan-2-yl-2-sulfanylidene-1,3-diazinane-4,6-dione Click to Show/Hide
Disease Class	9A76-9A78: Corneal disease
Therapeutic Class	Anxiolytics/Sedatives/Hypnotics
Structure
Structure	3D Structure		2D Structure
Formula	C11H18N2O2S
InChI	1S/C11H18N2O2S/c1-4-6-7(3)11(5-2)8(14)12-10(16)13-9(11)15/h7H,4-6H2,1-3H3,(H2,12,13,14,15,16)
InChIKey	IUJDSEJGGMCXSG-UHFFFAOYSA-N
Canonical SMILES	CCCC(C)C1(C(=O)NC(=S)NC1=O)CC
External Link
	Pubchem ID	3000715
	CAS Number	76-75-5
	CHEBI ID	102166
	TTD ID	D00MYT
	INTEDE ID	DR1580

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM009 Altered absorption (Unspecific) BM014 Interference of cell/tissue uptake BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM026 Increased metabolism (Unspecific) BM036 Additive cardiorespiratory depression effects BM038 Additive CNS depression effects BM042 Additive hypotensive effects BM087 Antagonize the effect of antiepileptic agents BM107 Attenuated pharmacological effects (Unspecific) BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Thiopental
Affected gastrointestinal absorption
	Altered absorption (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0337		Cimetidine	C10H16N6S	2756	Minor		Inter Info	[78]
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1822		Iodide I-123	I-	135300	Moderate		Inter Info	[63], [61], [64]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0676		Fluoxetine	C17H18F3NO	3386	Minor		Inter Info	[81], [82]
	CYP450 enzyme induction					Drug Num: 31
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0011		Acetaminophen	C8H9NO2	1983	Moderate		Inter Info	[11], [12], [13], [14]
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[21], [22], [23]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[24], [25], [26]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[21], [22], [23]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[34], [35], [27], [17], [36], [37], [38], [39], [40], [41], [42]
D0508		Disopyramide	C21H29N3O	3114	Moderate		Inter Info	[43]
D0530		Doxycycline	C22H24N2O8	54671203	Moderate		Inter Info	[44], [45]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[21], [22], [23]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[24], [25], [26]
D1138		Nimodipine	C21H26N2O7	4497	Moderate		Inter Info	[24], [25], [26]
D1141		Nisoldipine	C20H24N2O6	4499	Moderate		Inter Info	[24], [25], [26]
D1143		Nitisinone	C14H10F3NO5	115355	Moderate		Inter Info	[46], [27], [17]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[21], [22], [23]
D1361		Protriptyline	C19H21N	4976	Moderate		Inter Info	[21], [22], [23]
D1570		Theophylline	C7H8N4O2	2153	Moderate		Inter Info	[49], [50], [51], [52]
D0064		Aminophylline	C16H24N10O4	9433	Moderate		Inter Info	[49], [50], [51], [52]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[21], [22], [23]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[55], [56], [57]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[21], [22], [23]
D0525		Doxepin	C19H21NO	667477	Moderate		Inter Info	[21], [22], [23]
D0526		Doxepin (topical)	C19H21NO	667477	Moderate		Inter Info	[21], [22], [23]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[24], [25], [26]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[24], [25], [26]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[24], [25], [26]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[72], [73], [74]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[21], [22], [23]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[77]
D0645		Fenoprofen	C15H14O3	3342	Minor		Inter Info	[79], [80]
D1078		Mitotane	C14H10Cl4	4211	Minor		Inter Info	[85]
D1229		Paroxetine	C19H20FNO3	43815	Minor		Inter Info	[86]
D1400		Rifampicin	C43H58N4O12	135398735	Minor		Inter Info	[88], [89], [90]
	Increased metabolism (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1353		Propafenone	C21H27NO3	4932	Minor		Inter Info	[87]
Pharmacodynamic additive effects
	Additive cardiorespiratory depression effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1356		Propofol	C12H18O	4943	Moderate		Inter Info	[66], [67], [68], [69], [70], [71]
	Additive CNS depression effects					Drug Num: 95
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0617		Ethanol	C2H6O	702	Major		Inter Info	[1], [2], [3], [4], [5]
D1485		Sodium oxybate	C4H7NaO3	23663870	Major		Inter Info	[9], [10]
D0030		Aldesleukin	NA	NA	Moderate		Inter Info	[15], [16], [17]
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[18], [19], [20]
D0160		Benzatropine	C21H25NO	1201549	Moderate		Inter Info	[29]
D0205		Brimonidine (ophthalmic)	C11H10BrN5	2435	Moderate		Inter Info	[30], [17], [31]
D0206		Brimonidine (topical)	C11H10BrN5	2435	Moderate		Inter Info	[30], [17], [31]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[18], [19], [20]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[18], [19], [20]
D0263		Carisoprodol	C12H24N2O4	2576	Moderate		Inter Info	[18], [19], [20]
D0305		Cetirizine	C21H25ClN2O3	2678	Moderate		Inter Info	[32], [33]
D0327		Chlorzoxazone	C7H4ClNO2	2733	Moderate		Inter Info	[18], [19], [20]
D0345		Citalopram	C20H21FN2O	2771	Moderate		Inter Info	[18], [19], [20]
D0351		Clemastine	C21H26ClNO	26987	Moderate		Inter Info	[18], [19], [20]
D0356		Clobazam	C16H13ClN2O2	2789	Moderate		Inter Info	[18], [19], [20]
D0403		Cyproheptadine	C21H21N	2913	Moderate		Inter Info	[18], [19], [20]
D0456		Dexbrompheniramine	C16H19BrN2	16960	Moderate		Inter Info	[18], [19], [20]
D0466		Dextromethorphan	C18H25NO	5360696	Moderate		Inter Info	[18], [19], [20]
D0532		Doxylamine	C17H22N2O	3162	Moderate		Inter Info	[18], [19], [20]
D0533		Dronabinol	C21H30O2	16078	Moderate		Inter Info	[18], [19], [20]
D0535		Droperidol	C22H22FN3O2	3168	Moderate		Inter Info	[18], [19], [20]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[18], [19], [20]
D0612		Eszopiclone	C17H17ClN6O3	969472	Moderate		Inter Info	[18], [19], [20]
D1096		Nabilone	C24H36O3	5284592	Moderate		Inter Info	[18], [19], [20]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[18], [19], [20]
D1335		Pregabalin	C8H17NO2	5486971	Moderate		Inter Info	[18], [19], [20]
D1347		Procyclidine	C19H29NO	4919	Moderate		Inter Info	[29]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[18], [19], [20]
D0097		Apomorphine	C17H17NO2	6005	Moderate		Inter Info	[53], [54]
D0098		Apraclonidine	C9H10Cl2N4	2216	Moderate		Inter Info	[30], [17], [31]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[18], [19], [20]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[18], [19], [20]
D0183		Biperiden	C21H29NO	2381	Moderate		Inter Info	[29]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Moderate		Inter Info	[18], [19], [20]
D0208		Brivaracetam	C11H20N2O2	9837243	Moderate		Inter Info	[18], [19], [20]
D0212		Bromocriptine	C32H40BrN5O5	31101	Moderate		Inter Info	[18], [19], [20]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[18], [19], [20]
D0259		Carbinoxamine	C16H19ClN2O	2564	Moderate		Inter Info	[18], [19], [20]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[18], [19], [20]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[18], [19], [20]
D0359		Clofedanol	C17H20ClNO	2795	Moderate		Inter Info	[18], [19], [20]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Moderate		Inter Info	[18], [19], [20]
D0398		Cyclobenzaprine	C20H21N	2895	Moderate		Inter Info	[18], [19], [20]
D0451		Desvenlafaxine	C16H25NO2	125017	Moderate		Inter Info	[18], [19], [20]
D0459		Dexmedetomidine	C13H16N2	5311068	Moderate		Inter Info	[18], [19], [20]
D0600		Esketamine	C13H16ClNO	182137	Moderate		Inter Info	[27], [58]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[18], [19], [20]
D0604		Estazolam	C16H11ClN4	3261	Moderate		Inter Info	[18], [19], [20]
D0621		Ethotoin	C11H12N2O2	3292	Moderate		Inter Info	[18], [19], [20]
D0639		Felbamate	C11H14N2O4	3331	Moderate		Inter Info	[18], [19], [20]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[59]
D0790		Ifosfamide	C7H15Cl2N2O2P	3690	Moderate		Inter Info	[60], [61], [62]
D0791		Iloperidone	C24H27FN2O4	71360	Moderate		Inter Info	[18], [19], [20]
D0878		Kava	C14H16O3	5281052	Moderate		Inter Info	[18], [19], [20]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[18], [19], [20]
D0917		Levocetirizine	C21H25ClN2O3	1549000	Moderate		Inter Info	[32], [33]
D0942		Lofexidine	C11H12Cl2N2O	30668	Moderate		Inter Info	[18], [19], [20]
D0959		Lumateperone	C24H28FN3O	21302490	Moderate		Inter Info	[18], [19], [20]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[18], [19], [20]
D1006		Mepyramine	C17H23N3O	4992	Moderate		Inter Info	[18], [19], [20]
D1014		Metaxalone	C12H15NO3	15459	Moderate		Inter Info	[18], [19], [20]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[18], [19], [20]
D1053		Metyrosine	C10H13NO3	441350	Moderate		Inter Info	[18], [19], [20]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[18], [19], [20]
D1084		Molindone	C16H24N2O2	23897	Moderate		Inter Info	[18], [19], [20]
D1172		Olopatadine (nasal)	C21H23NO3	5281071	Moderate		Inter Info	[61], [65], [28]
D1182		Opicapone	C15H10Cl2N4O6	135565903	Moderate		Inter Info	[18], [19], [20]
D1188		Orphenadrine	C18H23NO	4601	Moderate		Inter Info	[18], [19], [20]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[18], [19], [20]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[18], [19], [20]
D1252		Pentoxyverine	C20H31NO3	2562	Moderate		Inter Info	[18], [19], [20]
D1253		Perampanel	C23H15N3O	9924495	Moderate		Inter Info	[18], [19], [20]
D1255		Pergolide	C19H26N2S	47811	Moderate		Inter Info	[18], [19], [20]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[18], [19], [20]
D1367		Quazepam	C17H11ClF4N2S	4999	Moderate		Inter Info	[18], [19], [20]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[18], [19], [20]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[18], [19], [20]
D1431		Rotigotine	C19H25NOS	59227	Moderate		Inter Info	[18], [19], [20]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[18], [19], [20]
D1502		St. John's Wort	NA	NA	Moderate		Inter Info	[18], [19], [20]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[18], [19], [20]
D1536		Tasimelteon	C15H19NO2	10220503	Moderate		Inter Info	[18], [19], [20]
D1560		Tetrabenazine	C19H27NO3	6018	Moderate		Inter Info	[18], [19], [20]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[61], [28], [75]
D1576		Thiothixene	C23H29N3O2S2	941651	Moderate		Inter Info	[18], [19], [20]
D1596		Tizanidine	C9H8ClN5S	5487	Moderate		Inter Info	[76]
D1644		Trimethobenzamide	C21H28N2O5	5577	Moderate		Inter Info	[18], [19], [20]
D1673		Valbenazine	C24H38N2O4	24795069	Moderate		Inter Info	[18], [19], [20]
D1675		Valerian	NA	NA	Moderate		Inter Info	[18], [19], [20]
D1719		Ziconotide	C102H172N36O32S7	16135415	Moderate		Inter Info	[18], [19], [20]
D1730		Zonisamide	C8H8N2O3S	5734	Moderate		Inter Info	[18], [19], [20]
D1604		Tolcapone	C14H11NO5	4659569	Moderate		Inter Info	[18], [19], [20]
D1641		Trihexyphenidyl	C20H31NO	5572	Moderate		Inter Info	[29]
D1677		Valproic acid	C8H16O2	3121	Moderate		Inter Info	[18], [19], [20]
D1726		Ziprasidone	C21H21ClN4OS	60854	Moderate		Inter Info	[18], [19], [20]
	Additive hypotensive effects					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1393		Reserpine	C33H40N2O9	5770	Moderate		Inter Info	[47], [48]
D0444		Deserpidine	C32H38N2O8	8550	Moderate		Inter Info	[47], [48]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0853		Isocarboxazid	C12H13N3O2	3759	Major		Inter Info	[6], [7], [8]
D1263		Phenelzine	C8H12N2	3675	Major		Inter Info	[6], [7], [8]
D1455		Selegiline	C13H17N	26757	Major		Inter Info	[6], [7], [8]
D1620		Tranylcypromine	C9H11N	19493	Major		Inter Info	[6], [7], [8]
D0143		Baclofen	C10H12ClNO2	2284	Moderate		Inter Info	[27], [17], [28]
Pharmacodynamic antagonistic effects
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0879		Ketamine	C13H16ClNO	3821	Minor		Inter Info	[27], [83], [84]

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