Drug General Information (ID: DDI0JDPYFI)
Drug Name			Methysergide		Drug Info		Ketamine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Vasoconstrictor Agents				Analgesics
Structure

Mechanism of Methysergide-Ketamine Interaction (Severity Level: Moderate)
Additive hypertensive effects Click to Show/Hide Mechanism Graph
Drug Name		Methysergide				Ketamine
Mechanism 1		Hypertensive effects				Hypertensive effects
Key Mechanism Factor 1
		Factor Name		Hypertensive effects
		Factor Description		Hypertension is defined as a blood pressure reading above a prescribed limit (130/90 mmHg). Most people with hypertension have no signs or symptoms; others may experience: severe headache, shortness of breath, nosebleeds, severe anxiety, and feeling a tingling sensation in the neck or head.
Mechanism Description		Additive hypertensive effects by the combination of Methysergide and Ketamine
Increased risk of rapid heart rate Click to Show/Hide Mechanism Graph
Drug Name		Methysergide				Ketamine
Mechanism 2		Tachycardia				Tachycardia
Key Mechanism Factor 2
		Factor Name		Tachycardia
		Factor Description		A faster-than-normal heart rate, but the heart is beating normally. Tachycardia may not cause any symptoms or complications, but if left untreated, some forms of tachycardia can lead to serious health problems, including heart failure, stroke, or sudden cardiac death.
Mechanism Description		Increased risk of rapid heart rate by the combination of Methysergide and Ketamine

Recommended Action
Management		Close monitoring of vital signs, including blood pressure and heart rate is recommended whenever ketamine is used concomitantly with direct or indirect acting sympathomimetics or vasopressin.

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	Product Information. Ketalar (ketamine). JHP Pharmaceuticals, Saddle River, NJ.