Details of Drug

Drug General Information (ID: D0857)
Drug Name	Isometheptene
Drug Type	Small molecule
Drug Synonymous	Octin (TN) Click to Show/Hide
Disease Class	2A00-2F9Z: Solid tumour/cancer
Therapeutic Class	Analgesics
Structure
Structure	3D Structure		2D Structure
Formula	C9H19N
InChI	1S/C9H19N/c1-8(2)6-5-7-9(3)10-4/h6,9-10H,5,7H2,1-4H3
InChIKey	XVQUOJBERHHONY-UHFFFAOYSA-N
Canonical SMILES	CC(CCC=C(C)C)NC
External Link
	Pubchem ID	22297
	CAS Number	503-01-5
	CHEBI ID	134765
	TTD ID	D0M1PQ

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM014 Interference of cell/tissue uptake BM018 Non-CYP450 enzyme inhibition BM041 Additive hypertensive effects BM061 Increased risk of hyperpyrexia BM078 Increased risk of rapid heart rate BM083 Potentiated the pharmacological effects (Unspecific) BM089 Antagonize the effect of antihypertensive agents
Relation Graph

Full list of drugs interacting with Isometheptene
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1821		Iobenguane (I-123)	C8H10IN3	60860	Moderate		Inter Info	[27], [1], [28]
Affected intra/extra-hepatic metabolism
	Non-CYP450 enzyme inhibition					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1437		Safinamide	C17H19FN2O2	131682	Moderate		Inter Info	[38], [39], [40]
Pharmacodynamic additive effects
	Additive hypertensive effects					Drug Num: 45
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0212		Bromocriptine	C32H40BrN5O5	31101	Major		Inter Info	[1], [2], [3]
D0494		Dihydroergotamine	C33H37N5O5	10531	Major		Inter Info	[4], [5], [6]
D0592		Ergometrine	C19H23N3O2	443884	Major		Inter Info	[4], [6], [7]
D0593		Ergotamine	C33H35N5O5	8223	Major		Inter Info	[4], [6], [7]
D1037		Methylergometrine	C20H25N3O2	8226	Major		Inter Info	[4], [6], [7]
D1043		Methysergide	C21H27N3O2	9681	Major		Inter Info	[4], [6], [7]
D0074		Amphetamine	C9H13N	3007	Moderate		Inter Info	[14], [15], [16]
D0103		Arformoterol	C19H24N2O4	3083544	Moderate		Inter Info	[17], [18], [19]
D0119		Atomoxetine	C17H21NO	54841	Moderate		Inter Info	[14], [15], [16]
D0165		Benzphetamine	C17H21N	5311017	Moderate		Inter Info	[14], [15], [16]
D0451		Desvenlafaxine	C16H25NO2	125017	Moderate		Inter Info	[23], [24], [25]
D0460		Dexmethylphenidate	C14H19NO2	154101	Moderate		Inter Info	[14], [15], [16]
D0465		Dextroamphetamine	C9H13N	5826	Moderate		Inter Info	[14], [15], [16]
D0486		Diethylpropion	C13H19NO	7029	Moderate		Inter Info	[14], [15], [16]
D0523		Doxapram	C24H30N2O2	3156	Moderate		Inter Info	[14], [15], [16]
D0538		Droxidopa	C9H11NO5	92974	Moderate		Inter Info	[26]
D0691		Formoterol	C19H24N2O4	3410	Moderate		Inter Info	[17], [18], [19]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[17], [18], [19]
D0854		Isoetharine	C13H21NO3	3762	Moderate		Inter Info	[17], [18], [19]
D0920		Levomilnacipran	C15H22N2O	6917779	Moderate		Inter Info	[23], [24], [25]
D0924		Levosalbutamol	C13H21NO3	123600	Moderate		Inter Info	[17], [18], [19]
D1171		Olodaterol	C21H26N2O5	11504295	Moderate		Inter Info	[17], [18], [19]
D1374		Racepinephrine	C9H13NO3	838	Moderate		Inter Info	[17], [18], [19]
D1492		Solriamfetol	C10H14N2O2	10130337	Moderate		Inter Info	[29]
D0859		Isoprenaline	C11H17NO3	3779	Moderate		Inter Info	[17], [18], [19]
D0879		Ketamine	C13H16ClNO	3821	Moderate		Inter Info	[33], [34], [35]
D0937		Lisdexamfetamine	C15H25N3O	11597698	Moderate		Inter Info	[14], [15], [16]
D0981		Mazindol	C16H13ClN2O	4020	Moderate		Inter Info	[14], [15], [16]
D1012		Metamfetamine	C10H15N	10836	Moderate		Inter Info	[14], [15], [16]
D1039		Methylphenidate	C14H19NO2	4158	Moderate		Inter Info	[14], [15], [16]
D1061		Midodrine	C12H18N2O4	4195	Moderate		Inter Info	[34], [7]
D1066		Milnacipran	C15H22N2O	65833	Moderate		Inter Info	[23], [24], [25]
D1185		Orciprenaline	C11H17NO3	4086	Moderate		Inter Info	[17], [18], [19]
D1210		Oxytocin	C43H66N12O12S2	439302	Moderate		Inter Info	[34], [36], [37]
D1262		Phendimetrazine	C12H17NO	30487	Moderate		Inter Info	[14], [15], [16]
D1270		Phentermine	C10H15N	4771	Moderate		Inter Info	[14], [15], [16]
D1281		Phenylpropanolamine	C9H13NO	26934	Moderate		Inter Info	[14], [15], [16]
D1298		Pirbuterol	C12H20N2O3	4845	Moderate		Inter Info	[17], [18], [19]
D1414		Ritodrine	C17H21NO3	33572	Moderate		Inter Info	[17], [18], [19]
D1438		Salbutamol	C13H21NO3	2083	Moderate		Inter Info	[17], [18], [19]
D1440		Salmeterol	C25H37NO4	5152	Moderate		Inter Info	[17], [18], [19]
D1464		Sibutramine	C17H26ClN	5210	Moderate		Inter Info	[36], [41], [42]
D1535		Tapentadol	C14H23NO	9838022	Moderate		Inter Info	[23], [24], [25]
D1554		Terbutaline	C12H19NO3	5403	Moderate		Inter Info	[17], [18], [19]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[23], [24], [25]
	Increased risk of hyperpyrexia					Drug Num: 8
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0853		Isocarboxazid	C12H13N3O2	3759	Major		Inter Info	[8], [9], [10]
D1036		Methylene blue	C16H18ClN3S	6099	Major		Inter Info	[8], [9], [10]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[8], [9], [10]
D0933		Linezolid	C16H20FN3O4	441401	Major		Inter Info	[11], [12], [13]
D1263		Phenelzine	C8H12N2	3675	Major		Inter Info	[8], [9], [10]
D1345		Procarbazine	C12H19N3O	4915	Major		Inter Info	[8], [9], [10]
D1455		Selegiline	C13H17N	26757	Major		Inter Info	[8], [9], [10]
D1620		Tranylcypromine	C9H11N	19493	Major		Inter Info	[8], [9], [10]
	Potentiated the pharmacological effects (Unspecific)					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1577		Thyroid, porcine	NA	NA	Moderate		Inter Info	[30], [31], [32]
D0925		Levothyroxine	C15H11I4NO4	5819	Moderate		Inter Info	[30], [31], [32]
D0934		Liothyronine	C15H12I3NO4	5920	Moderate		Inter Info	[30], [31], [32]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antihypertensive agents					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0444		Deserpidine	C32H38N2O8	8550	Moderate		Inter Info	[20], [21], [22]
D0743		Guanadrel	C10H19N3O2	38521	Moderate		Inter Info	[20], [21], [22]
D0744		Guanethidine	C10H22N4	3518	Moderate		Inter Info	[20], [21], [22]
D1393		Reserpine	C33H40N2O9	5770	Moderate		Inter Info	[20], [21], [22]

References
1	Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
2	Gittelman DK "Bromocriptine associated with postpartum hypertension, seizures, and pituitary hemorrhage." Gen Hosp Psychiatry 13 (1991): 278-80.[PMID: 1874430]
3	Kulig K, Moore LL, Kirk M, Smith D, Stallworth J, Rumack B "Bromocriptine-associated headache: possible life-threatening sympathomimetic interaction." Obstet Gynecol 78 (1991): 941-3.[PMID: 1923236]
4	Barthel W, Glusa E, Koth W "Interactions of dihydroergotamine with etilefrine in human leg veins in vitro and in situ." Int J Clin Pharmacol Ther Toxicol 25 (1987): 63-9. [PMID: 2881898]
5	Buchanan N, Cane RD, Miller M "Symmetrical gangrene of the extremities associated with the use of dopamine subsequent to ergometrine administration." Intensive Care Med 3 (1977): 55-6. [PMID: 561121]
6	Product Information. D.H.E. 45 (dihydroergotamine). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
7	Product Information. ProAmatine (midodrine). Roberts Pharmaceutical Corporation, Eatontown, NJ.
8	Davies B, Bannister R, Sever P "Pressor amines and monoamine-oxidase inhibitors for treatment of postural hypotension in autonomic failure: limitations and hazards." Lancet 1 (1978): 172-5. [PMID: 74603]
9	Goulet JP, Perusse R, Turcotte JY "Contraindications to vasoconstrictors in dentistry: Part III. Pharmacologic interactions." Oral Surg Oral Med Oral Pathol 74 (1992): 692-7. [PMID: 1359489]
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12	Product Information. Matulane (procarbazine). Roche Laboratories, Nutley, NJ.
13	Product Information. Zyvox (linezolid) Pharmacia and Upjohn, Kalamazoo, MI.
14	Product Information. Focalin (dexmethylphenidate). Mikart Inc, Atlanta, GA.
15	Product Information. Strattera (atomoxetine). Lilly, Eli and Company, Indianapolis, IN.
16	Cavanaugh JH, Griffith JD, Oates JA "Effect of amphetamine on the pressor response to tyramine: formation of p-hydroxynorephedrine from amphetamine in man." Clin Pharmacol Ther 11 (1970): 656
17	Lowe MD, Rowland E, Brown MJ, Grace AA "Beta(2) adrenergic receptors mediate important electrophysiological effects in human ventricular myocardium." Heart 86 (2001): 45-51. [PMID: 11410561]
18	Product Information. Breo Ellipta (fluticasone-vilanterol). GlaxoSmithKline, Research Triangle Park, NC.
19	Product Information. Brovana (arformoterol). Sepracor Inc, Marlborough, MA.
20	Gulati OD, Dave BT, Gokhale SD, Shah KM "Antagonism of adrenergic neuron blockade in hypertensive subjects." Clin Pharmacol Ther 7 (1966): 510-4. [PMID: 5939974]
21	Ziegler CH, Lovette JB "Operative complications after therapy with reserpine and reserpine compounds." JAMA 176 (1961): 114-7
22	Spiers AS, Calne DB "Action of dopamine on the human iris." Br Med J 4 (1969): 333-5
23	Product Information. Cymbalta (duloxetine). Lilly, Eli and Company, Indianapolis, IN.
24	Product Information. Fetzima (levomilnacipran). Forest Pharmaceuticals, St. Louis, MO.
25	Product Information. Nucynta (tapentadol). PriCara Pharmaceuticals, Raritan, NJ.
26	Product Information. Northera (droxidopa). Chelsea Therapeutics Inc, Charlotte, NC.
27	Gilman AG, Rall TW, Nies AS, Taylor P, eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 8th ed." New York, NY: Pergamon Press Inc. (1990):.
28	Product Information. AdreView (iobenguane I-123). GE Healthcare, Princeton, NJ.
29	Product Information. Sunosi (solriamfetol). Jazz Pharmaceuticals, Palo Alto, CA.
30	Product Information. Armour thyroid (thyroid desiccated). Forest Pharmaceuticals, St. Louis, MO.
31	Product Information. Synthroid (levothyroxine). Abbott Pharmaceutical, Abbott Park, IL.
32	Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA."
33	Cerner Multum, Inc. "Australian Product Information.".
34	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
35	Product Information. Ketalar (ketamine). JHP Pharmaceuticals, Saddle River, NJ.
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37	Product Information. Syntocinon (oxytocin). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
38	Cusson JR, Goldenberg E, Larochelle P "Effect of a novel monoamine-oxidase inhibitor, moclobemide on the sensitivity to intravenous tyramine and norepinephrine in humans." J Clin Pharmacol 31 (1991): 462-7. [PMID: 2050833]
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40	Product Information. Xadago (safinamide). US WorldMeds LLC, Louisville , KY.
41	Product Information. Didrex (benzphetamine) Pharmacia and Upjohn, Kalamazoo, MI.
42	Product Information. Meridia (sibutramine). Knoll Pharmaceutical Company, Whippany, NJ.

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