Details of Drug Interaction

Details of Drug-Drug Interaction

 Drug General Information (ID: DDIJDF8H46)
  Drug Name Bromocriptine Drug Info Isometheptene Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Antiparkinson Agents Analgesics
  Structure

 Mechanism of Bromocriptine-Isometheptene Interaction (Severity Level: Major)
     Additive hypertensive effects Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Bromocriptine Isometheptene
      Mechanism Hypertensive effects
Alpha-1 adrenergic receptor  Agonist 		Hypertensive effects
Alpha-1 adrenergic receptor  Agonist
      Key Mechanism Factor 1
Factor Name Adrenergic receptor alpha-1 Structure Sequence
Protein Family G-protein coupled receptor 1 family
Protein Function
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.
    Click to Show/Hide
      Mechanism Description
  • Additive hypertensive effects by the combination of Bromocriptine and Isometheptene 

Recommended Action
      Management Until more information is available, the concurrent use of these agents should be avoided.

References
1 Product Information. Fycompa (perampanel). Eisai Inc, Teaneck, NJ.
2 Gittelman DK "Bromocriptine associated with postpartum hypertension, seizures, and pituitary hemorrhage." Gen Hosp Psychiatry 13 (1991): 278-80.[PMID: 1874430]
3 Kulig K, Moore LL, Kirk M, Smith D, Stallworth J, Rumack B "Bromocriptine-associated headache: possible life-threatening sympathomimetic interaction." Obstet Gynecol 78 (1991): 941-3.[PMID: 1923236]